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9780781746786

Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy

by ; ; ; ; ;
  • ISBN13:

    9780781746786

  • ISBN10:

    0781746787

  • Format: Paperback
  • Copyright: 2004-04-13
  • Publisher: LWW
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Supplemental Materials

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Summary

Unlike other pharmacology texts organized by drug class, Principles of Pharmacology integrates relevant knowledge from the basic biomedical sciences - physiology, pathophysiology, cell and molecular biology, biochemistry, anatomy, neurobiology, microbiology and immunology - to build an integrated, conceptual understanding of drug therapy. By discussing the therapeutic and adverse actions of drugs in the framework of the drug's mechanism of action, the book enables students to achieve a level of mastery in pharmacology that far surpasses that achieved by rote memorization. The result is a primary pharmacology textbook that is ideal for a systems-based or discipline-based course in pharmacology.

Table of Contents

Forewordp. vii
Prefacep. ix
Acknowledgmentsp. xi
Contributorsp. xiii
Fundamental Principles of Pharmacologyp. 1
Drug-Receptor Interactionsp. 3
Pharmacodynamicsp. 17
Pharmacokineticsp. 27
Drug Metabolismp. 45
Principles of Neuropharmacologyp. 55
Fundamental Principles of Neuropharmacologyp. 57
Principles of Cellular Excitability and Electrochemical Transmissionp. 59
Principles of Nervous System Physiology and Pharmacologyp. 71
Principles of Autonomic and Peripheral Nervous System Pharmacologyp. 87
Cholinergic Pharmacologyp. 89
Adrenergic Pharmacologyp. 107
Local Anesthetic Pharmacologyp. 121
Principles of Central Nervous System Pharmacologyp. 137
Pharmacology of Excitatory and Inhibitory Neurotransmissionp. 139
Pharmacology of Dopaminergic Neurotransmissionp. 161
Pharmacology of Affective Disordersp. 179
Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous Systemp. 193
General Anesthetic Pharmacologyp. 205
Pharmacology of Analgesiap. 229
Pharmacology of Chemical Dependence and Addictionp. 247
Principles of Cardiovascular Pharmacologyp. 265
Pharmacology of Cardiac Rhythmp. 267
Pharmacology of Cardiac Contractilityp. 285
Pharmacology of Volume Regulationp. 299
Pharmacology of Vascular Tonep. 317
Pharmacology of Hemostasis and Thrombosisp. 335
Pharmacology of Cholesterol and Lipoprotein Metabolismp. 357
Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Congestive Heart Failurep. 375
Principles of Endocrine Pharmacologyp. 401
Pharmacology of the Hypothalamus and Pituitary Glandp. 403
Pharmacology of the Thyroid Glandp. 415
Pharmacology of the Adrenal Cortexp. 425
Pharmacology of Reproductionp. 441
Pharmacology of the Endocrine Pancreasp. 457
Pharmacology of Bone Mineral Homeostasisp. 473
Principles of Chemotherapyp. 491
Principles of Antimicrobial and Antineoplastic Pharmacologyp. 493
Pharmacology of Nucleotide Synthesisp. 505
Pharmacology of DNA Replication and Mitosisp. 519
Pharmacology of Transcription and Translationp. 535
Pharmacology of Viral Replicationp. 545
Pharmacology of the Bacterial Cell Wallp. 565
Pharmacology of Fungal Infectionsp. 579
Pharmacology of Parasitic Infectionsp. 587
Principles of Combination Chemotherapyp. 603
Principles of Inflammation and Immune Pharmacologyp. 615
Principles of Inflammation and the Immune Systemp. 617
Pharmacology of Eicosanoidsp. 627
Histamine Pharmacologyp. 647
Pharmacology of Hematopoietic and Immune Cell Stimulationp. 655
Pharmacology of Immunosuppressionp. 667
Integrative Inflammation Pharmacology: Peptic Ulcer Diseasep. 683
Integrative Inflammation Pharmacology: Asthmap. 695
Integrative Inflammation Pharmacology: Goutp. 709
Principles of Toxicologyp. 717
Principles of Toxicologyp. 719
Contemporary Approaches to Drug Discovery, Development and Deliveryp. 745
Drug Discovery and Developmentp. 747
Protein-Based and Gene Therapiesp. 757
Drug Delivery Mechanismsp. 781
Fundamentals of Drug Evaluation and Pharmacogenomicsp. 789
New Drug Evaluation and Drug Regulationp. 791
Pharmacogenomicsp. 803
Credit Listp. 811
Indexp. 815
Table of Contents provided by Rittenhouse. All Rights Reserved.

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