9781621821649

Prostate Cancer

by ;
  • ISBN13:

    9781621821649

  • ISBN10:

    1621821641

  • Format: Hardcover
  • Copyright: 2018-04-30
  • Publisher: Cold Spring Harbor Laboratory Press
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Summary

Prostate cancer is the second most common type of cancer and affects millions of individuals worldwide. This volume reviews our understanding of the disease, its progression, and new therapeutic approaches.

Topics covered in this essential volume include:


·Anatomy and Histology of the Human and Murine Prostate


·Prostate Cancer Genetics


·Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood


·Stem Cells and Cancer Stem Cells


·Epigenetics


·New Opportunities for Targeting the Androgen Receptor in Prostate Cancer


·Chemoprevention in Prostate Cancer: Current Perspective and Future Directions

Table of Contents


(preliminary)

Foreword
Charles Sawyers

1. Introduction
Michael Shen and Mark Rubin

2. Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann

3. Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain

4. Epidemiology
Lorelei Mucci

5. Prostate Cancer Genetics
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles

6. Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck

7. Stem Cells and Cancer Stem Cells
Michael Shen

8. Pre-neoplastic Lesions
Angelo DeMarzo

9. Histopathology of Prostate Cancer
Peter A. Humphrey

10. Genomics
Mark Rubin

11. Transcriptional Regulation
Myles Brown

12. Epigenetics
Srinivasan Yegnasubramanian

13. Androgen signaling in prostate cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi

14. New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler,
and Wayne D. Tilley

15. DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen

16. Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero Jr., Ian M. Thompson Jr., Michael A. Liss, and Dharam Kaushik

17. Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson

18. Genetically Engineered Mouse Models of Prostate Cancer in the Post-Genomic Era
Juan M. Arriaga and Cory Abate-Shen

19. Pre-Clinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor

20. Preclinical and Co-Clinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi

21. Tumor Evolution
Francesca DeMichelis

22. Metabolism
Massimo Loda

23. Metastasis
George Thalmann

24. Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models and Therapy
Loredana Puca, Panagiotis J. Vlachosterogios, and Himisha Beltran

25. Biomarkers
Scott Tomlins

26. Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmalsi, and Robert E. Reiter

27. Immunotherapy
Charles Drake

28. Therapies for Advanced Disease
Semini Sumanasuriya and Johann De Bono

Index

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