9783527323517

Reactive Intermediates : MS Investigations in Solution

by
  • ISBN13:

    9783527323517

  • ISBN10:

    3527323511

  • Format: Hardcover
  • Copyright: 2010-02-01
  • Publisher: Vch Pub

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Summary

Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI-MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized. With an introduction by Noble laureate John Fenn

Author Biography

After being awarded his MSc in 1999 Leonardo Silva Santos joined the Universidade Estadual de Campinas in Brasil for his thesis working on the total synthesis of natural products, while also doing research for two years at the University of Chicago in 2001-2002. After beind awarded his Ph.D. in 2003 he did postdoctoral research at UNICAMP, Brasil, and at the Carl von Ossietzky Universit+t Oldenburg. He is currently Professor at the Universidad de Talca, Chile.

Table of Contents

Foreword
Preface
List of Contributors
A Brief Overview of the Mechanisms Involved in Electrospray Mass Spectrometry
Introduction
Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry
Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry From the Gas Phase to Solution
A Brief History and Recent Advances in Mass Spectrometry
Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry
Future Perspectives
Organic Reaction Studies by ESI-MS
Introduction
Reaction Mechanisms
General Remarks
Studies of Reaction Mechanism Intermediates by ESI-MS
Introduction
Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions
Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions
Studies on the Intermediates and Mechanism of Organocatalysis Reactions
Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions
On-line Monitoring Reactions by Electrospray Ionization Mass Spectrometry
Introduction
Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique
Developing Methods to Study Reaction Mechanisms
Probing Reactivity of Intermediates
Conclusion
Gas Phase Ligand Fragmentation to Unmask Reactive Metallic Species
Introduction and Scope of the Review
Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation
Conclusions
Palladium Intermediates in Solution
Introduction
ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions
ESI-MS Studies in the Identification of Oxidative Addition Intermediates
ESI-MS Studies in Mizoroki-Heck and Related Reactions
ESI-MS Studies in Stille Cross-Coupling Reactions
ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes
ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions
ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions
ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols
ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions
Conclusions
Practical Investigation of Molecular and Biomolecular Noncovalent Recognition Processes in Solution by ESI-MS
Introduction
Methods and Applications
Practical Aspects of Titration Analysis
Summary and Outlook
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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