9781118125656

Ribosome-inactivating Proteins Biology and Applications

by ;
  • ISBN13:

    9781118125656

  • ISBN10:

    1118125657

  • Format: Hardcover
  • Copyright: 6/9/2014
  • Publisher: Wiley-Blackwell
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Summary

This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.

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