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Based on one of the leading encyclopedic resources in cell and molecular biology worldwide, this two-volume work contains more than 75% new content, not previously published in the Encyclopedia. All the other chapters have been carefully updated. The result is a comprehensive overview of the different functions of the various forms of RNA in living organisms, with each contributor carefully selected and an internationally recognized expert on his or her field. Special focus is on the different forms of expression regulation through RNA, with medical applications in the treatment of diseases -- from cancers and immune responses to infections and aging -- covered in detail. At least 45 of the 55 articles are new content previously not published in the Encyclopedia.
Dr. Robert A. Meyers, the Editor in Chief (EiC) of the Encyclopedia of Cell and Molecular Biology and Molecular Medicine, originated the Encyclopedia and continues responsibility for the project. Dr. Meyers has a Ph.D. in organic chemistry from UCLA and was a postdoctoral and faculty member at the California Institute of Technology. He is president of Ramtechlimited and is author or editor in chief of an additional twelve books and 20 technical papers as well as ten patents.
Table of Contents
I Bioinformatic and Computational Methods
RNA-regulatory networks Integrative Modeling Robert B. Darnell Rockefeller U
II Medical Applications
Regulation in Aging Myriam Gorospe NIH NIAging Cancer miRNAs in Cancer Scott Hammond University of North Carolina at Chapel Hill Cancer Non-Protein-Coding RNAs (ncRNAs) at Gene Promoter Regions in Cancer David Corey UT Southwestern Cancer Translation regulation by microRNAs in leukemia Shobha Vasudevan Massachusetts General Hospital, Harvard Medical School General Pharmacology and Emerging Clinical Application of RNA Barik, Sailen University of South Alabama Hepatitis Infection RNAi to Treat Chronic Hepatitis B Virus Infection Arbuthnot P University of the Witwatersrand Medical School, Hepatitis Infection RNAi to Treat Chronic Hepatitis C Infection Linda Couto Childrens Hospital of Philadelphia HIV Infection RNAi Gene Therapy to Control HIV-1 Infection Ben Berkhout and Olivier ter Brake University of Amsterdam Immunity RNA responses to cell stress in the immune response Paul Anderson Harvard Medical School Immunity RNA-based immune regulators Jens Lykke-Andersen University of California ? San Diego Infections Cellular miRNAs in Mammalian Antiviral Immune Responses Joost Haasnoot and Ben Berkhout University of Amsterdam Infections Virally Encoded miRNAs Thomas Tuschl Rockefeller U
III Methods for Analysis and Manipulation of RNA-mediated Regulation
Characterization RNA Methodologies Farrell, Jr., Robert E. Penn State University Vectors Bacterial Vectors for RNAi Delivery Johannes H. Fruehauf Harvard Medical School Vectors Lipid-like molecules for Delivery of RNAi to cells. Robert Langer MIT Vectors Nanoparticles for Small Interfering RNA Delivery Daniel G. Anderson MIT Vectors RNAi Delivery with Viral Vectors Robbins PD University of Pittsburgh School of Medicine Vectors RNAi Delivery Optimization John Rossi Beckman Research Institute of the City of Hope Characterization RNAi Screening and Assays Christophe J. Echeverri Cenix BioScience GmbH
IV Molecular Cell Biology
Antisense Antisense-RNA regulation Sabine Brantl Friedrich Schiller Univ. Jena Apoptosis RNA regulation in apoptosis Imed Gallouzi McGill University, Canada Bacteria Bacterial tmRNA regulation of the cell cycle and developmental process Kenneth Keiler Pennsylvania State University Bacteria Small regulatory non-coding RNAs in bacteria Francis Repoila INSERM Core Article Regulation of Gene Expression Anil Kumar Devi Ahilya University Developmental miRNAs (Micro RNAs) in Developmental Processes Frank J. Slack Yale U Developmental miRNA-targeted mRNAs that control cellular differentiation pathways Amy Pasquinelli University of California, San Diego Developmental RNA Regulation in Myogenesis Roberto Gherzi University of Genoa, Italy Developmental RNA Silencing in Periconception Deborah Bourc'his CNRS Paris Function Large Intergenic Noncoding RNAs (lincRNAs) John L. Rinn Beth Israel Deaconess Medical Center and Harvard Medical School Function Non-coding RNAs in imprinted gene clusters Jerome Cavaille LBME-CNRS Function Non-coding RNAs regulating the transcriptional machinery Olivier Bensaude CNRS Ecole Normale Superieure Function Non-Protein-Coding RNAs (ncRNAs) in Chromatin Function Eran Segal Weizmann Institute of Science Function Ribonome and Gene Expression Jack D. Keene Duke University Medical Center Function Riboswitches in Gene Regulation Tina M. Henkin Ohio State University Function RNA Editing and Nucleotide Modification Eric M. Phizicky University of Rochester Medical Center Function RNA Interference in the Nucleus Gunter Meister Max Planck Institute of Biochemistry, Martinsried Function Translate or to Degrade a Cytoplasmic mRNA Decision Mechanism Ann-Bin Shyu University of Texas, Medical School Fundamental Processes RNA-induced initiation of transcriptional silencing (RITS) Complex Structure and Functions Robert A. Martienssen Cold Spring Harbor Fundamental Processes RNA-Induced Silencing Complex (RISC) Structure and Functions Erik J. Sontheimer Northwestern University Insects RNAi Based Antiviral Immune System in Insects Maria-Carla Saleh Pasteur Institute Insects RNA-Mediated Gene Regulation in Drosophila Richard Morgan National Institutes of Health Plants RNA silencing Cell to Cell movement in plants Kriton Kalantidis Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas Plants RNA Silencing in Plants David Baulcombe University of Cambridge Silencing dsRNA mediated gene silencing process Andrew Z. Fire Stanford University Silencing Gene Knockdown in Mice with siRNA Inder M. Verma Salk Institute Stability RNA stability in mammalian cells Ann-Bin Shyu University of Texas - Houston Medical School Stem Cells RNA Induced Pluripotent Stem Cells (RiPS) Doug Melton Harvard Stem Cell Insitute Structure RNA as a Regulator of Chromatin Structure Antonio Rodriguez-Campos Institute of Molecular Biology of Barcelona (IBMB), Transport Direct Visualization of RNA transport and localization of specific RNAs within individual cells Robert H. Singer Albert Einstein College of Medicine Transport mRNP (messenger ribonucleoprotein) export to the Cytoplasm Domenico Libri CNRS Transport Nuclear Export and Maturation of Ribosomes Arlen W. Johnson University of Texas at Austin Transport siRNAs Transport from the Cytoplasm to the Nucleus Scott Kennedy University of Wisconsin?Madison Transport tRNA Subcellular Dynamics Anita T. Hopper Ohio State University Viruses RNA regulatory processes in viruses Jeff Wilusz Colorado State University