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Called "one of the most prominent discoveries of the decade" by Nobel Laureate Phillip Sharp, RNA interference (RNAi) constitutes the ability of double-stranded RNA molecules to shut down expression of genes containing homologous sequences. During the last few years, RNAi technology has been embraced as a gene function analysis tool by all major pharmaceutical and academic establishments around the world. RNAi in Drug Discovery and Development provides comprehensive analysis of all aspects of RNAi technology-from basic chemical and biological principles, to applications, further to drug discovery and therapeutic developments-through contributions from prominent specialists in the field.