9780444520210

Contemporary Aspects of Boron: Chemistry and Biological Applications highlights the biological activity and applications of boron containing compounds. The authors specific approach surveys general features of the subject, while exploring new and novel strategies for preparing certain chemical and natural boron products that are of significant substance in medicinal chemistry. For example, cancer treatment is one of the most important issues related to such products. In addition to contributing to the development of new drugs by addressing biological applications in medicinal and industrial fields, the book provides a comprehensive review of the most relevant components that comprise the pharmaceutical, medicinal and environmental applications of boron containing compounds. * Timely and comprehensive * Provides new insights to active researchers in the field * Presents concepts and methods in simple scientific terms

Chemistry of the diboron compounds

1

(58)

H. Abu Ali

V.M. Dembitsky

M. Srebnik

Introduction

2

(1)

Preparation of Diboron Compounds and their Properties

3

(13)

Reactions of Diboron Compounds

16

(43)

References

52

(7)

Recent developments in bisdiborane chemistry: B-C-B, B-C-C-B, B-C=C-B, and B-C≡C-B compounds and their biological applications

59

(60)

H. Abu Ali

V. M. Dembitsky

M. Srebnik

Introduction

60

(1)

Formation of B-C-B Compounds

61

(7)

Geminal Organoboron Compounds

68

(17)

Formation, Reactivity and Biological Activity of B-C-C-B, B-C=C-B, and B-C≡C-B Compounds

85

(34)

References

113

(6)

Applied Suzuki cross-coupling reaction for syntheses of biologically active compounds

119

(180)

V.M. Dembitsky

H. Abu Ali

M. Srebnik

Introduction

120

(1)

Synthesis of Biologically Active Compounds via Cross Coupling Reaction Catalyzed by Palladium

120

(13)

Cross-coupling of Alkynylborane Derivatives with Haloarenes

133

(22)

Cross-coupling of Alkynylborane Derivatives

155

(11)

Cross-coupling of Alkylborane Derivatives

166

(18)

Synthesis of Macrocycles

184

(38)

Modification of Nucleosides using Suzuki-Miyaura Coupling

222

(14)

Synthesis of Substituted Porphyrins

236

(5)

Additional Application of the Suzuki Cross-coupling Reaction

241

(2)

Synthesis of Macrocyclic Compounds

243

(7)

Synthesis of Tetracyclic Systems

250

(11)

Synthesis of Polycyclic Ethers

261

(6)

Synthesis of Disubstituted Furans

267

(3)

Synthesis of GeranylGeranyl Diphosphate Derivatives

270

(1)

Synthesis of Spiroquinolizidine Derivatives

271

(2)

Synthesis of Carbohydrate-Substituted Phosphines

273

(7)

Synthesis of Novel Thyroid Hormone Analogues: 5'-Aryl Substituted GC-1 Derivatives

280

(19)

References

282

(17)

Synthesis of selected biologically active compounds via allylboration

299

(38)

V. M. Dembitsky

H. Abu Ali

M. Srebnik

Introduction

300

(1)

Synthesis of Heterocyclic Compounds

301

(18)

Synthesis of N-Lactone Rings

319

(7)

Allylboration of Nitrogen Heterocycles

326

(11)

References

331

(6)

Boron neutron capture therapy

337

(30)

A. K. Azab

H. Abu Ali

M. Srebnik

Introduction

338

(1)

The Concept of Boron Neutron Capture Therapy

338

(3)

BNCT in the Treatment of Cancer

341

(3)

Boron Targeting to Cancer Tissues

344

(16)

Summary

360

(7)

References

361

(6)

Boron enolates in the syntheses of natural products

367

(24)

V. M. Dembitsky

H. Abu Ali

M. Srebnik

Introduction

369

(1)

Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide

369

(1)

Enantioselective Total Synthesis of (+)-Leucascandrolide- A Macrolactone

370

(1)

Synthesis of the C29-C51 Subunit of Altohyrtin C (Spongistatin 2)

371

(1)

Asymmetric Synthesis of the Polyene Macrolide Antibiotic RK-397

372

(1)

Asymmetric Total Synthesis of Spongistatins 1 and 2

372

(1)

Synthesis of the Microtubule-Stabilizing Agent (-)-Laulimalide

373

(1)

Synthesis of (2S,3S)- and (2R,3R)-β-Hydroxyornithine

374

(1)

Synthesis of Concanamycin F

374

(1)

Synthesis of an Isomer of Membrenone C

375

(1)

Synthesis of Doliculide

376

(1)

Synthesis of Tri- and Tetrapeptide S: the Extended C-Terminus of Bleomycin A2

376

(1)

Synthesis of A (9S)-Macrolide Intermediate for Oleandomycin

377

(1)

Synthetic Studies on Antitumor Antibiotic Bleomycin

377

(1)

Synthesis of the Esterase Inhibitor (±)- Ebelactone A

378

(1)

Synthesis of the Oviposition-Deterring Pheromone in Rhagoletis cerasi

378

(1)

Synthesis of (±)-Hernandulcin

379

(1)

Synthesis of β-Lactam Antibiotics

379

(1)

Synthesis of (+)-Pseudomonic Acid C

380

(1)

Synthesis of Masamune Norephedrine Esters

381

(1)

Synthesis of L-Daunosamine and D-Ristosamine Derivatives

381

(1)

SEMI- Synthesis of Taxol

382

(1)

Synthesis of the Pyrrolizidine Ring System

382

(1)

Synthesis of (-)-Branched Unusual Amino Acids

383

(1)

Synthesis of a-Amino Acids

383

(1)

Synthesis of 1-β-Methylcarbapenem Antibiotics

384

(1)

Synthesis of Nakadomarin

385

(1)

Synthesis of 11-β, 17-β-Diaryl-18A-Homo-19-Norsteroids

385

(1)

Synthesis of the Central C18-C30 Core of the Phorboxazole

386

(1)

Synthesis of A C17-C32 Subunit of Scytophycin C

386

(1)

Synthesis of the Archaebacterial C40 Diol

387

(1)

Synthesis of Anthracycline Glycosides

387

(4)

References

388

(3)

Boronated saccharides: potential applications

391

(104)

R. Smoum

M. Srebnik

Introduction

393

(1)

Boronic Acids-Saccharide Interaction; the Basics

393

(3)

Chemosensing

396

(38)

Transport

434

(12)

Boron and Plants

446

(5)

Chromatography

451

(10)

Boron and Diabetes

461

(4)

Boron and Cancer

465

(5)

Drug Delivery

470

(2)

Miscellaneous Biological Applications of Boron Saccharide Interactions

472

(23)

References

479

(16)

α-Aminoboronic acids, amine cyanoboranes, amine carboxyboranes and their derivatives

495

(56)

K. Takrouri

V.M. Dembistky

M. Srebnik

Introduction

496

(1)

α-Aminoboronic Acids

496

(26)

Amine Cyanoboranes and Amine Carboxyboranes

522

(15)

Biological Activities of Amine Cyano- and Carboxyboranes and their Derivatives

537

(14)

References

544

(7)

Environmental aspects of boron

551

(48)

A. Shibli

M. Srebnik

Introduction

552

(1)

Boron Chemistry

553

(7)

Boron in Soils

560

(2)

Boron in Plants

562

(18)

Water Desalination

580

(19)

References

593

(6)

Index

599

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Contemporary Aspects of Boron: Chemistry and Biological Applications

044452021X

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