9780521856973

Secondary Schizophrenia

by
  • ISBN13:

    9780521856973

  • ISBN10:

    0521856973

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-03-15
  • Publisher: Cambridge University Press
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Summary

Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience - understanding and conquering this most mysterious of human diseases.

Author Biography

Perminder S. Sachdev is Scientia Professor of Neuropsychiatry at the school of Psychiatry, university of New south Wales, and Clinical Director of the Neuropsychiatric institute (NPI), the Prince of Wales Hospital, Sydney, Australia. MatchEri S. Keshavan is Professor and Vice Chair of Psychiatry, Beth Israel Deaconess Medical center, Harvard Medical School, Boston, Massaachusetts, USA.

Table of Contents

List of contributorsp. vii
Prefacep. xiii
Introduction
Neurobiology and etiology of primary schizophrenia: current statusp. 3
The concept of organicity and its application to schizophreniap. 16
Secondary hallucinationsp. 21
The neurology of schizophrenia
The neurologic examination in schizophreniap. 47
Functional neuroimaging in schizophreniap. 60
Organic syndromes of schizophrenia
Epilepsy and schizophrenia
Schizophrenia-like psychosis and epilepsyp. 79
Understanding the pathophysiology of schizophrenia through the looking glass of forced normalizationp. 103
Drugs and schizophrenia-like psychosis
Substance-induced psychosis: an overviewp. 112
Stimulants and psychosisp. 127
Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia?p. 141
Schizophrenia secondary to cannabis usep. 169
Toxic psychosisp. 179
Other neurological disorders
Schizophrenia-like psychosis and traumatic brain injuryp. 186
Cerebrovascular disease and psychosisp. 197
Neurodegenerative disorders (Alzheimer's Disease, fronto-temporal dementia) and schizophrenia-like psychosisp. 204
Storage disorders and psychosisp. 214
Mitochondrial disorders and psychosisp. 229
Psychosis associated with leukodystrophiesp. 241
Normal pressure hydrocephalusp. 257
Brain tumorsp. 263
Demyelinating disease and psychosisp. 273
Systemic disorders
Infection and schizophreniap. 279
Genetic disorders related to SLP
The status of genetic investigations of schizophreniap. 288
Velocardiofacial syndrome (chromosome 22q11.2 deletion syndrome) as a model of schizophreniap. 309
Psychosis in Prader-Willi Syndromep. 328
Friedreich's Ataxia and schizophrenia-like psychosisp. 332
Wilson's Diseasep. 337
Huntington's Disease and related disorders and their association with schizophrenia-like psychosisp. 348
Fahr's Disease and psychosisp. 358
Related concepts
The Charles Bonne tSyndromep. 369
Acute brief psychosis-an organic syndrome?p. 380
Treatment
Drug treatment of secondary schizophreniap. 393
Nonpharmacological interventions in secondary schizophreniap. 406
Indexp. 419
Table of Contents provided by Ingram. All Rights Reserved.

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