Signaling by Toll-Like Receptors

by Konat; Gregory W.

• ISBN13: 9781420043181
• ISBN10: 1420043188
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-06-20
• Publisher: CRC Press

Summary

The recent discovery of an ancient family of proteins that serve as toll-like receptors(TLRs) in the immune system has revolutionized the potential for a variety of therapies, for both failing immune systems, which leaves the body open to infection or over-active ones, which can lead to chronic inflammation. Signaling by Toll-Like Receptors provides a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors, as well as the high promise for uncovering effective pharmaceutical targets.

Table of Contents

Series Preface	p. vii
Preface	p. ix
About the Editor	p. xi
Contributors	p. xiii
Abbreviations	p. xv
List of Protocols	p. xix
Assessing the Response of Cells to TLR Stimulation	p. 1
TLR Ligands in Experimental Settings Their Purity and Specificity	p. 23
Analysis of TLR Expression, Regulation, and Signaling	p. 39
Intracellular Trafficking of Toll-Like Receptors	p. 59
The Role of Small RhoGTPases in TLR Signaling	p. 73
Use of Engineered [beta]-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors	p. 87
Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling	p. 109
Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling	p. 131
Role of Toll-Like Receptor Signaling in Central Nervous System Infections	p. 145
The Influence of Injury on Toll-Like Receptor Responses	p. 163
Index	p. 181
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