Statistical Learning for Biomedical Data

by James D. Malley , Karen G. Malley , Sinisa Pajevic

• ISBN13: 9780521875806
• ISBN10: 0521875803
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-03-28
• Publisher: Cambridge University Press

Summary

This book is for anyone who has biomedical data and needs to identify variables that predict an outcome, for two-group outcomes such as tumor/not-tumor, survival/death, or response from treatment. Statistical learning machines are ideally suited to these types of prediction problems, especially if the variables being studied may not meet the assumptions of traditional techniques. Learning machines come from the world of probability and computer science but are not yet widely used in biomedical research. This introduction brings learning machine techniques to the biomedical world in an accessible way, explaining the underlying principles in nontechnical language and using extensive examples and figures. The authors connect these new methods to familiar techniques by showing how to use the learning machine models to generate smaller, more easily interpretable traditional models. Coverage includes single decision trees, multiple-tree techniques such as Random Forests(TM), neural nets, support vector machines, nearest neighbors and boosting.

Table of Contents

Preface

Acknowledgements

Introduction

Prologue

The landscape of learning machines

A mangle of machines

Three examples and several machines

A Machine Toolkit

Logistic regression

A single decision tree

Random forests - trees everywhere

Analysis Fundamentals

Merely two variables

More than two variables

Resampling methods

Error analysis and model validation

Machine Strategies

Ensemble methods - let's take a vote

Summary and conclusions

References

Index

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