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Stem cell engineering allows scientists to manipulate stem cells artificially for the purpose of studying and controlling their survival, potency, proliferation, migration, specific differentiation, plasticity, immunocompatibility, fate in vivo, and other properties. This new research area holds great promise for researchers using stem cells for testing the safety and effects of new drugs, for the treatment of disease, and for the regeneration of injured tissues. This volumes brings researchers from engineering, chemistry, physics, and biology to discuss basic and advanced topics in this burgeoning field.