Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.
- Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
- Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
- Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types
SECTION 1: INTRODUCTION
Ch01 Different stem cell types and their potential for cancer therapeutics Angelo Vescovi and Khalid Shah
SECTION 2: MIGRATION AND FATE OF STEM CELLS
Ch02 2.1. Role of CXCR4 in tumoritropic migration of stem cells. Moneeb Ehtesham
Ch03 2.2. MMP-1 mediated tumoritrophic migration of stem cells. Paula Lam
SECTION 3: STEM CELL THERAPY IN BRAIN CANCER
Brain tumors and TRAIL mediated glioma therapy utilizing different stem cell types.
Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma.
Ch06 3.3. Role of naïve cord blood stem cells on glioma therapy
Venkata Ramesh Dasari,Kiran Kumar Velpula, Christopher S. Gondi, Jasti S. Rao
Ch07 3.4. Targeting brain tumor vasculature with engineered neural stem cells.
Navid Redjal and Khalid Shah
Ch08 3.5. Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells.
Manuel Ramirez and Javier Garcia-Castro
SECTION 4: STEM CELL THERAPY IN OTHER CANCER TYPES
Ch09 4.1. Umbilical cord matrix stem cells for cytotherapy of breast cancer
Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, Susumu Ishiguro, Deryl Troyer, Masaaki Tamura
Ch10 4.2. Mesenchymal stromal cells as effective tumor antigen-presenting cells in cancer therapeutics
Raphaëlle Romieu-Mourez and Jacques Galipeau
Ch11 4.3.Diagnostic and TherapeuticMesenchymal stem cell for breast cancer treatment
Ch12 4.4. Genetically Engineered Stem Cell Therapies Targeting Gastrointestinal Malignancy
Emily Keung, Peter J. Nelson and Claudius Conrad
Ch13 4.5. Mesenchymal stem cells in prostate cancer: Clinical Opportunities.
Diptiman Chanda and Selvarangan Ponnazhagan
Ch14 4.6. Primed mesenchymal stromal cells for cancer therapy
Augusto Pessina, Arianna Bonomi, Eugenio Parati, Roberto Pallini and Giulio Alessandri
SECTION 5: COMBINATORIAL STEM CELL THERAPIES
Ch15 5.1. Therapeutic efficacy of the combination of targeting microRNAs and stem cell released therapeutics on tumors.
Maarten Anderegg and Marten Corsten
Ch16 5.2. Therapeutic efficacy of PI3-Kinase inhibitors with stem cell delivered TRAIL therapy in tumors.
Ch17 5.3. The efficacy of clinically approved agents with stem cell delivered therapeutics for cancer therapy.
Hiroaki Wakimoto and Khalid Shah
SECTION 6: TRACKING STEM CELLS AND STEM CELL BASED THERAPEUTICS
Ch18 6.1. Imaging migration and fate of stem cells in different tumor models.
Deepak Bhere and Khalid Shah
Ch19 6.2. Integrating therapeutic and diagnostic activities in stem cell expressing molecules to reveal multiple aspects of stem cell-based therapy.
Ch20 6.3. Tracking cancer targeted MSC by PET imaging.
Véronique Roelants and Jean-Louis Vanoverschelde