Studies on Experimental Models

by Basu, Samar; Wiklund, Lars

• ISBN13: 9781607619550
• ISBN10: 1607619555
• Format: Hardcover
• Copyright: 2011-03-20
• Publisher: Humana Pr Inc

Summary

There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent.Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models.

Table of Contents

Diabetes
Role of Oxidative Stress and Targeted Antioxidant Therapies in Experimental Models of Diabetic Complications	p. 3
Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and Diabetes	p. 39
Cardiovascular
Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-Tocotrienol as a Unique Therapeutic Agent	p. 63
Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance Spectroscopy	p. 91
Small Heat Shock Proteins and Doxorubicin-Induced Oxidative Stress in the Heart	p. 105
Oxidative Stress in Cardiovascular Disease: Potential Biomarkers and Their Measurements	p. 131
In vivo Imaging of Antioxidant Effects on NF-KB Activity in Reporter Mice	p. 157
Neurology
MPTP and Oxidative Stress: It's Complicated!	p. 187
Oxidative Stress in Alzheimer's Disease: A Critical Appraisal of the Causes and the Consequences	p. 211
Retinal Disturbances in Patients and Animal Models with Huntington's, Parkinson's and Alzheimer's Disease	p. 221
Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells	p. 251
The Use of Gpx4 Knockout Mice and Transgenic Mice to Study the Roles of Lipid Peroxidation in Diseases and Aging	p. 265
An Experimental Model of Myocardial and Cerebral Global Ischemia and Reperfusion	p. 279
Ocular Diseases
Neovascular Models of the Rabbit Eye Induced By Hydroperoxide	p. 303
Purinergic Signaling Involved in the Volume Regulation of Glial Cells in the Rat Retina: Alteration in Experimental Diabetes	p. 319
Toxicology/Environmental
Helicobacter pylori-Induced Oxidative Stress and Inflammation	p. 343
Experimental Models for Ionizing Radiation Research	p. 371
Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vivo in Preclinical Models, and in Smokers and Patients with Airways Disease	p. 399
Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPD	p. 421
Induction of Oxidative Stress by Iron/Ascorbate in Isolated Mitochondria and by UV Irradiation in Human SkinIngrid Wiswedel	p. 441
Carbon Tetrachloride-Induced Hepatotoxicity: A Classic Model of Lipid Peroxidation and Oxidative Stress	p. 467
Enhanced Urinary Excretion of Lipid Metabolites Following Exposure to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative Stress	p. 481
Oxidative Stress in Animal Models with Special Reference to Experimental Porcine Endotoxemia	p. 497
Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Skeletal Muscle	p. 511
Exercise as a Model to Study Interactions Between Oxidative Stress and Inflammation	p. 521
Exercise as a Model to Study Oxidative Stress	p. 531
In Vitro/Tissue Culture
Models of Mitochondrial Oxidative Stress	p. 545
Protection of Oxidant-Induced Neuronal Cells Injury by a Unique Cruciferous Nutraceutical	p. 563
Oxidatively Generated Damage to DNA and Biomarkers	p. 579
Measuring Oxidative Stress in Cell Cultures, Animals and Humans: Analysis and Validation of Oxidatively Damaged DNA	p. 605
The Roles of cAMP and G Protein Signaling in Oxidative Stress-Induced Cardiovascular Dysfunction	p. 621
Cellular and Chemical Assays for Discovery of Novel Antioxidants in Marine Organisms	p. 637
Arsenic-Induced Oxidative Stress: Evidence on In Vitro Models of Cardiovascular, Diabetes Mellitus Type 2 and Neurodegenerative Disorders	p. 659
Index	p. 681
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