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Demographic changes, immigration, economic upheavals, and changing societal mores are creating new and altered structures, processes, and relationships in American families today. As families undergo rapid change, family science is at the brink of a new and exciting integration across methods, disciplines, and epistemological perspectives. The purpose of The Science of Research on Families: A Workshop, held in Washington, DC, on July 13-14, 2010, was to examine the broad array of methodologies used to understand the impact of families on children's health and development. It sought to explore individual disciplinary contributions and the ways in which different methodologies and disciplinary perspectives could be combined in the study of families. Toward an Integrated Science of Research on Familiesdocuments the information presented in the workshop presentations and discussions. The report explores the idea of family research as being both basic and applied, offering opportunities for learning as well as intervention. It discusses research as being most useful when organized around particular problems, such as obesity or injury prevention. Toward an Integrated Science of Research on Familiesoffers a problem-oriented approach that can guide a broad-based research program that extends across funders, institutions, and scientific disciplines.