did-you-know? rent-now

Amazon no longer offers textbook rentals. We do!

did-you-know? rent-now

Amazon no longer offers textbook rentals. We do!

We're the #1 textbook rental company. Let us show you why.

9781936113217

Type 1 Diabetes

by ; ;
  • ISBN13:

    9781936113217

  • ISBN10:

    193611321X

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2012-07-25
  • Publisher: Cold Spring Harbor Laboratory Press

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

Purchase Benefits

  • Free Shipping Icon Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • eCampus.com Logo Get Rewarded for Ordering Your Textbooks! Enroll Now
  • Write a Review Icon Write a Review
List Price: $144.00 Save up to $53.28
  • Rent Book $90.72
    Add to Cart Free Shipping Icon Free Shipping

    TERM
    PRICE
    DUE
    USUALLY SHIPS IN 3-5 BUSINESS DAYS
    *This item is part of an exclusive publisher rental program and requires an additional convenience fee. This fee will be reflected in the shopping cart.

Supplemental Materials

What is included with this book?

Summary

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing ? cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this book provides a detailed examination of our understanding of the disease process and its causes, as well as a genetic risk factors, animal models or diabetes, and new treatment strategies that are being developed.

Table of Contents

Prefacep. vii
The Pathogenesis and Natural History of Type 1 Diabetesp. 1
Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humansp. 19
Generating ß Cells from Stem Cells-The Story So Farp. 39
Endoplasmic Reticulum Stress, Pancreatic ß-Cell Degeneration, and Diabetesp. 51
Genetics of Type 1 Diabetesp. 69
Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypesp. 85
Immunologic and Metabolic Biomarkers of (ß-Cell Destruction in the Diagnosis of Type 1 Diabetesp. 103
Islet Autoantigens: Structure, Function, Localization, and Regulationp. 117
Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?p. 137
Antigen Targets of Type 1 Diabetes Autoimmunityp. 155
The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetesp. 169
Environmental Triggers of Type 1 Diabetesp. 179
Virus Infections in Type 1 Diabetesp. 195
Connecting Type 1 and Type 2 Diabetes through Innate Immunityp. 209
Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Micep. 227
Antigen-Specific Therapeutic Approaches in Type 1 Diabetesp. 241
Clinical Immunologic Interventions for the Treatment of Type 1 Diabetesp. 265
Update on Islet Transplantationp. 283
Indexp. 299
Table of Contents provided by Ingram. All Rights Reserved.

Supplemental Materials

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

Rewards Program