9780470019221

Viral Therapy of Cancer

by ; ;
  • ISBN13:

    9780470019221

  • ISBN10:

    0470019220

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2008-06-09
  • Publisher: Wiley

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Summary

In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient's bedside, they give an up-to-date and realistic evaluation of a therapy's potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical researchViral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

Table of Contents

Foreword
Preface
Contributors
Adenoviruses
Introduction
Viral structure and life cycle
Adenoviral vectors
Targeting adenoviral vectors
Clinical applications of adenoviral gene therapy
Adenoviral vectors for immunotherapy
Adenoviral vectors for suicide gene therapy
Adenoviral vectors for gene replacement therapy
Oncolytic adenoviral therapy
Adverse outcomes of adenoviral gene therapy
Summary
References
Application of HSV-1 Vectors to the treatment of cancer
Introduction
Basic biology of HSV
Replication competent or oncolytic vectors
Replication defective vectors
Amplicons
Impediments to the efficacy of HSV vectors for cancer gene therapy
Strategies to enhance the efficacy and specificity of HSV vectors for cancer gene therapy
Summary and conclusions
Acknowledgements
References
Adeno-associated virus
Introduction
Biology and life cycle of AAV
AAV serotypes
Production of recombinant AAV
Gene therapy for cancer treatment
Anti-oncogenic properties of AAV
Molecular chemotherapy studies with rAAV
AAV-mediated sustained transgene expression as a potential cancer gene therapy strategy
rAAV vectors have advantages in stimulating T helper 1/cytotoxic T lymphocyte responses
rAAV vectors can be used to initiate immune responses
Altering AAV tropism for tumour-specific delivery
Clinical trials involving rAAV
Conclusion
Acknowledgements
References
Retroviruses
Introduction
Structure of retroviral particles
Retroviral genome
Retroviral life cycle
Retroviral vectors
Safety of retroviral vectors: insertional mutagenesis
Gene therapy of X-linked SCID
Retroviral cancer gene therapy
Immunomodulatory approaches
Conclusions
References
Lentiviral vectors for cancer gene therapy
Development of Lentiviral vectors (LV)
Targeting of transgene expression
Host immune responses to LV and their transgene
Transgenesis
Haematopoietic stem cell gene transfer
Cancer treatment by LV
Approved clinical trials using LV
Conclusions
References
Poxviruses as immunomodulatory cancer therapeutics
Introduction
General features of poxvirus structure and biology
Clinically applicable poxviruses
Poxviruses as potential cancer therapeutics
Clinical experience with poxviruses
Conclusion
References
Oncolytic herpes simplex viruses
Introduction
Herpes simplex virology
Properties of HSV relevant to oncolytic virus therapy
Mutations giving tumour-selective replication
Oncolytic HSV expressing fusogenic membrane glycoproteins (FMG)
Prodrug activation therapy and oncolytic HSV
Combination of oncolytic HSV with immunomodulatory gene expression
Combination of conventional therapies with oncolytic HSV
Summary
Acknowledgement
References
Selective tumour cell cytoto
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