Jagat Narula MD, PhD Professor of Medicine, Chief, Division of Cardiology, Associate Dean, University of California, Irvine, School of Medicine, Irvine, CA, USA
Martin B. Leon MD Professor of Medicine, Center for Interventional Vascular Therapy, Columbia University Medical Center, New York NY, USA
James T. Willerson MD President, The University of Texas Health Science Center at Houston, President-Elect and Medical Director, Texas Heart Institute, Houston TX, USA
Introduction | |
History of atherosclerosis and vulnerable plaque research | |
Pathology | |
The pathology of vulnerable plaque | |
Plaque rupture | |
Plaque erosion | |
Pathogenesis and significance of calcification in coronary atherosclerosis | |
Adventitial and periadventitial fat inflammation and plaque vulnerability | |
Murine models of advanced atherosclerosis | |
Triggers for plaque rupture | |
Physical and mechanical stress | |
Inflammation and matrix metalloproteinases | |
Apoptosis in atherosclerosis | |
Diagnosis | |
Emerging biomarkers of instability | |
Ultrasonic detection of coronary disease | |
Intravascular ultrasound for plaque characterization | |
Magnetic resonance imaging and intravascular magnetic resonance imaging | |
Radionuclide imaging | |
Near-infrared spectroscopy | |
Intravascular thermography | |
Optical coherence tomography | |
Intravascular palpography | |
Coronary computed tomography for the detection of atherosclerotic plaqueburden | |
Management | |
New developments in treatment of vulnerable plaques | |
Photodynamic therapy | |
Thermal stabilization of vulnerable plaques | |
An interventionalist's perspective | |
Genetic modulation of vulnerable plaques | |
Index | |
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