The Vulnerable Atherosclerotic Plaque

by Editor: Renu Virmani (International Registry of Pathology, MD, USA); Editor: Jagat Narula (University of California, Irvine); Editor: Martin B. Leon (Columbia University Medical Center, NY); Editor: James T. Willerson (Texas Heart Institute, Hous

• ISBN13: 9781405158596
• ISBN10: 140515859X
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-12-01
• Publisher: Wiley-Blackwell

Summary

Finally, a convenient, one-volume summary of current knowledge on an area of increasing importance! The Vulnerable Atherosclerotic Plaque presents contributions from the best investigators in the field, skillfully edited for easy reading and lavishly illustrated with high-quality, full-color images.After a considered and concise introduction, the book concentrates on: Pathology of vulnerable plaque Triggers for plaque rupture Imaging of unstable plaque Management of vulnerable plaques Careful editing allows the authors to avoid repetition and provide comprehensive coverage of pathology, detection, and management. This thorough and authoritative reference will change the way interventionists look at the disease.

Author Biography

Renu Virmani MD Medical Director, CVPath, International Registry of Pathology, Gaithersburg MD, USA

Jagat Narula MD, PhD Professor of Medicine, Chief, Division of Cardiology, Associate Dean, University of California, Irvine, School of Medicine, Irvine, CA, USA

Martin B. Leon MD Professor of Medicine, Center for Interventional Vascular Therapy, Columbia University Medical Center, New York NY, USA

James T. Willerson MD President, The University of Texas Health Science Center at Houston, President-Elect and Medical Director, Texas Heart Institute, Houston TX, USA

Table of Contents

Introduction

History of atherosclerosis and vulnerable plaque research

Pathology

The pathology of vulnerable plaque

Plaque rupture

Plaque erosion

Pathogenesis and significance of calcification in coronary atherosclerosis

Adventitial and periadventitial fat inflammation and plaque vulnerability

Murine models of advanced atherosclerosis

Triggers for plaque rupture

Physical and mechanical stress

Inflammation and matrix metalloproteinases

Apoptosis in atherosclerosis

Diagnosis

Emerging biomarkers of instability

Ultrasonic detection of coronary disease

Intravascular ultrasound for plaque characterization

Magnetic resonance imaging and intravascular magnetic resonance imaging

Radionuclide imaging

Near-infrared spectroscopy

Intravascular thermography

Optical coherence tomography

Intravascular palpography

Coronary computed tomography for the detection of atherosclerotic plaqueburden

Management

New developments in treatment of vulnerable plaques

Photodynamic therapy

Thermal stabilization of vulnerable plaques

An interventionalist's perspective

Genetic modulation of vulnerable plaques

Index

Table of Contents provided by Publisher. All Rights Reserved.