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For over half a century,Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistryhas served the discipline of medicinal chemistry for both graduate and undergraduate pharmacy and chemistry students as well as practicing pharmacists. Fully updated for the Twelfth Edition, the book begins with the fundamental principles of chemistry, biochemistry, and biology that underlie the discipline of medicinal chemistry. These principles are then applied to understanding the properties, mode of action, therapeutic applications, and limitations of various pharmaceutical agents. The subject matter is organized by pharmaceutical and therapeutic classes, providing a bridge between the basic sciences and clinical practice. The text contains many tables for quick reference to names, formulations, dosages, and applications. This edition includes chapter review questions and cases.A companion website provides online updates of medicinal chemistry structures and an image bank for faculty.
Table of Contents
Introduction Drug Design Strategies Metabolic Changes of Drugs and Related Organic Compounds Biotechnology and Drug Discovery Immunobiologicals Anti-infective Antimalarials Antibacterial Antibiotics Antiviral Agents Antineoplastic Agents Agents for Diagnostic Imaging Central Nervous System Depressant Central Dopaminergic Signaling Agents Anticonvulsants Central Nervous System Stimulants Adrenergic Agents Cholinergic Drugs Renal Acting Agents Cardiovascular Agents Hormone Related Disorders: Nonsteroidal Therapies Agents Treating Bone Disorders Anesthetics Histamine and Antihistaminic Agents Analgesics Steroids and Therapeutically Related Compounds Prostaglandins, Leukotrienes, and Other Eicosanoids Proteins, Enzymes and Peptide Hormones Vitamins and Related Compounds An Introduction to the Medicinal Chemistry of Herbs Appendix, Calculated Log 0, Log D and pKa