Wnt Signaling in Development and Disease Molecular Mechanisms and Biological Functions

by Hoppler, Stefan P.; Moon, Randall T.

• ISBN13: 9781118444160
• ISBN10: 1118444167
• Edition: 1st
• Format: Hardcover
• Copyright: 2014-05-12
• Publisher: Wiley-Blackwell

Summary

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network.

• A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.

• Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases

• Reviews the complex processes of signal integration and regulation

• Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.

Author Biography

Stefan P. Hoppler, PhD, is Professor in Developmental Biology at the School of Medical Sciences at the University of Aberdeen. In addition to his teaching duties Prof. Hoppler runs research programs looking at Wnt inhibitors in heart muscle differentiation and tissue-specific regulation of gene expression by Wnt/beta-catenin signalling, and he also serves on the editorial board for the journal Developmental Dynamics.

Randall T. Moon, PhD, is Professor of Pharmacology at the University of Washington School of Medicine. His lab focuses on identifying the normal roles of Wnt signaling in embryos and adults and applying that knowledge to develop therapies for acute and chronic medical conditions involving Wnt signaling. Dr. Moon is Founding Director of the University of Washington Institute for Stem Cell and Regenerative Medicine, and a member of the Paul Allen Brain Institute Cell Networks Advisory Council, the HHMI Medical Research Fellows Program panel, and College of CSR Reviewers for NIH.

Table of Contents

 

1. Wnt signal production, secretion and diffusion
   Madelon M. Maurice and Hendrik C. Korswagen
   
   
2. Wnt signaling at the membrane
   Gary Davidsonand Christof  Niehrs
   
   
3. Wnt signal transduction in the cytoplasm: an introduction to the destruction complex
   Tony W. Chen, Heather A. Wallace, Yashi Ahmed and Ethan Lee
   
   
4. An overview of gene regulation by Wnt/b-catenin signaling
   Chen U. Zhang and Ken M. Cadigan
   
   
5. Finding a Needle in a Genomic Haystack: Genome-wide Approaches to Identify Wnt/TCF Transcriptional Targets
   Chandan Bhambhani and Ken M. Cadigan
   
   
6. Introduction to b-catenin independent Wnt signaling pathways
   Susanne Kühl and Michael Kühl
   
   
7. Molecular mechanisms of Wnt pathway specificity
   Alexandra Schambony, Guido J.R. Zaman, Folkert Verkaar
   
   
8. Modulation of Wnt signaling by endocytosis of receptor complexes
   Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, Akira Sato
   
   
9. New insights from proteomic analysis of WNT signaling
   Matthew P. Walker, Dennis Goldfarband Michael B. Major
   
   
10. New insights about Wnt pathway mechanisms from global siRNA screens
    Tenzin Gocha and Ramanuj DasGupta
    
    
11. Mathematical models of Wnt signaling pathways
    Michael Kühl, Barbara Kracher, Alexander Groß, and Hans Kestler
    
    
12. The Wnt’s tale:  On the evolution of a signaling pathway
    Jenifer C. Croce and Thomas W. Holstein
    
    
13. Secreted Wnt inhibitors or modulators
    Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve and Herbert Steinbeisser
    
    
14. Frizzleds as G protein-coupled receptors
    Gunnar Schulte
    
    
15. Dishevelled, at the crossroads of pathways
    Vítězslav Bryja and Ondřej Bernatík
    
    
16. β-catenin: a key player in both cell adhesion and wnt signaling
    Jonathan Pettitt
    
    
17. Evolutionary Diversification of vertebrate TCF/LEF structure, function, and regulation
    Stefan Hoppler and Marian L. Waterman
    
    
18. Insights from Structural Analysis of Protein-protein Interactions by Wnt Pathway Components and Functional Multi-protein Complex Formation
    Zhihong Cheng and Wenqing Xu
    
    
19. Wnt signaling in early vertebrate development: from fertilization to gastrulation
    Eliza Zylkiewicz, Sergei Y. Sokol and Stefan Hoppler
    
    
20. Wnt/ß-catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development
    Kathryn C. Davidson
    
    
21. Wnt Signaling Specifying Neural Lineages
    Richard Dorsky
    
    
22. Wnt signaling in Heart Organogenesis
    Stefan Hoppler, Silvia Mazzotta and Michael Kühl
    
    
23. Wnt signaling in kidney organogenesis
    Kimmo Halt and Seppo Vainio
    
    
24. Wnt signaling regulation of tissue architecture (EMT and MET) and morphogenesis: consequences for Colorectal and Liver Cancer
    T Fifis, BM Tran BM, RHM Schwab, TM Johanson, N Warner, N Barker, E Vincan
    
    
25. Wnt signaling in adult stem cells: tissue homeostasis and regeneration
    Frank J.T. Staal and Riccardo Fodde
    
    
26. Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury
    Günes Özhan and Gilbert Weidinger
    
    
27. Wnt Signaling and colorectal cancer
    Kevin Myant and Owen J Sansom
    
    
28. Wnt signaling in melanoma
    Jamie N. Anastas and Andy J. Chien
    
    
29. Wnt Signaling in Mood & Psychotic Disorders
    Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya
    
    
30. Neuropsychiatric Disease-associated Genetic Variation in the Wnt Pathway
    Stephen J. Haggarty, Karun Singh, Roy H. Perlis, Rakesh Karmacharya
    
    
31. Wnt Signaling in Dementia
    Stephen J. Haggarty
    
    
32. Therapeutic targeting of the Wnt signaling network
    Felicity Rudge and Trevor Dale