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This book provides a coherent, clear, and uniform presentation of structural, genetic, molecular, and biochemical information available for the ZP domain and ZPDC-proteins. The chapters discuss the structure of the ZP domain, the role (mechanism) of the ZP domain in polymerization of ZPDC-proteins and its regulation, the diversity of functions of ZPDC-proteins in a variety of organisms, from molluscs to human beings, diseases caused by mutations in ZPDC-proteins, and information on the evolution of the ZP domain and potential therapeutics as related to ZPDC-proteins.