Abeloff's Clinical Oncology

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  • Edition: 4th
  • Format: Hardcover
  • Copyright: 2008-05-21
  • Publisher: Elsevier Science Health Science div

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Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention all in one convenient resource equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format summary boxes a full-color design and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online fully searchable from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Table of Contents

Science of Clinical Oncologyp. 1
Biology and Cancer
Molecular Tools in Cancer Researchp. 3
Intracellular Signalingp. 21
The Cellular Microenvironment and Metastasesp. 33
Control of the Cell Cyclep. 49
Cell Life and Deathp. 67
Cancer Immunologyp. 77
Stem Cells, Cell Differentiation, and Cancerp. 95
Vascular and Interstitital Biology of Tumorsp. 105
Genesis of Cancer
Environmental Factorsp. 125
DNA Damage Response Pathways and Cancerp. 139
Viruses and Human Cancerp. 153
Genetic Factors: Hereditary Cancer Predisposition Syndromesp. 171
Genetic Factors: Finding Cancer Susceptibility Genesp. 193
Progressing from Gene Mutations to Cancerp. 207
Immunodeficiency and Cancerp. 223
Diagnosing Cancer: Pathology and Laboratory Medicine
Principles of Oncologic Surgical Pathologyp. 233
Flow Cytometry in Oncologic Diagnosisp. 241
Conventional and Molecular Cytogenetics of Neoplasiap. 249
Molecular Diagnosticsp. 265
Biomarkers for Cancer Diagnosticsp. 277
Imagingp. 283
Preventing and Treating Cancer
Biostatistics and Bioinformatlcs in Clinical Trialsp. 309
Structures Supporting Cancer Clinical Trialsp. 327
Economic Analysis of Cancer Treatmentp. 337
Use of Epidemiology in Oncologyp. 343
Cancer Prevention, Screening, and Early Detectionp. 361
Nicotine Dependence: Current Treatments and Future Directionsp. 397
Surgical Interventions in Cancerp. 407
Basics of Radiation Therapyp. 417
Systemic Therapyp. 449
Principles of Molecularly Targeted Therapy: Present and Futurep. 485
Hematopoietic Stem Cell Transplantationp. 501
Gene Therapy in Oncologyp. 513
Therapeutic Antibodies and Immunologic Conjugatesp. 531
Complementary and Alternative Medicinep. 545
Problems Common to Cancer and its Therapyp. 563
Symptom Management and Palliative Care
Cancer Painp. 565
Rehabilitation of Individuals with Cancerp. 579
Cachexiap. 591
Nausea and Vomitingp. 599
Oral Complicationsp. 609
Alopecia and Cutaneous Complicationsp. 625
Lymphedemap. 641
Fatiguep. 657
Caring for Patients at the End of Lifep. 665
Hematologic Problems
Disorders of Blood Cell Production in Clinical Oncologyp. 677
Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosisp. 693
Infection in the Patient with Cancerp. 717
Metabolic and Paraneoplastic Syndromes
Hypercalcemiap. 739
Hyponatremiap. 749
Tumor Lysis Syndromep. 759
Paraneoplastic Neurologic Syndromesp. 767
Surgical Problems
Establishing and Maintaining Vascular Accessp. 779
Acute Abdomen, Bowel Obstruction, and Fistulap. 792
Local Effects of Cancer and Its Metastasis
Superior Vena Cava Syndromep. 803
Spinal Cord Compressionp. 815
Brain Metastases and Neoplastic Meningitisp. 827
Bone Metastasesp. 845
Lung Metastasesp. 873
Liver Metastasesp. 885
Effusionsp. 925
Complications of Therapy
Neurologic Complicationsp. 945
Pulmonary Complications of Anticancer Treatmentp. 969
Cardiac Effects of Cancer Therapyp. 983
Reproductive Complicationsp. 999
Endocrine Complicationsp. 1013
Second Malignant Neoplasmsp. 1023
Special Populations
Cancer in the Elderly: Biology, Prevention, and Treatmentp. 1039
Special Issues in Pregnancyp. 1049
HIV-Associated Malignanciesp. 1061
Specific Malignanciesp. 1073
Cancer of the Central Nervous Systemp. 1075
Eye, Orbit, and Adnexal Structuresp. 1137
Cancer of the Head and Neckp. 1177
Melanomap. 1229
Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomasp. 1253
Cancer of the Endocrine Systemp. 1271
Cancer of the Lung: Non-Small Cell Lung Cancerp. 1307
Tumors of the Pleura and Mediastinump. 1367
Cancer of the Esophagusp. 1399
Cancer of the Stomachp. 1431
Cancer of the Small Bowelp. 1465
Colon Cancerp. 1477
Cancer of the Rectump. 1535
Cancer of the Anal Canalp. 1557
Liver and Bile Duct Cancerp. 1569
Carcinoma of the Pancreasp. 1595
Cancer of the Kidneyp. 1613
Carcinoma of the Bladderp. 1635
Prostate Cancerp. 1653
Cancer of the Penisp. 1701
Testicular Cancerp. 1713
Cancers of the Cervix, Vulva, and Vaginap. 1745
Cancer of the Endometriump. 1793
Ovaries and Fallopian Tubesp. 1827
Gestational Trophoblastic Diseasep. 1857
Cancer of the Breastp. 1875
Sarcomas of Bonep. 1945
Sarcomas of Soft Tissuep. 2009
Carcinoma of Unknown Primaryp. 2057
Pediatric Solid Tumorsp. 2075
World Health Organization Classification of Hematologic Malignanciesp. 2131
Childhood Leukemiap. 2139
Childhood Lymphomap. 2171
Acute Lymphocytic Leukemia in Adultsp. 2191
Acute Myeloid Leukemia in Adultsp. 2215
Myelodysplastic Syndromesp. 2235
Myeloproliferative Disordersp. 2261
Chronic Myeloid Leukemiap. 2279
Chronic Lymphoid Leukemiasp. 2293
Hairy Cell Leukemiap. 2309
Multiple Myeloma and Related Disordersp. 2323
Hodgkin's Lymphomap. 2353
Non-Hodgkin's Lymphomap. 2371
Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphomap. 2405
Adult T-Cell Leukemia-Lymphomap. 2425
Indexp. 2443
Table of Contents provided by Blackwell. All Rights Reserved.

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