Abeloff's Clinical Oncology

by Abeloff, Martin D.; Armitage, James O.; Niederhuber, John E.; Kastan, Michael B., M.D., Ph.D.

• ISBN13: 9780443066948
• ISBN10: 0443066949
• Edition: 4th
• Format: Hardcover
• Copyright: 2008-05-21
• Publisher: Elsevier Science Health Science div

Summary

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention all in one convenient resource equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format summary boxes a full-color design and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online fully searchable from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Table of Contents

Science of Clinical Oncology	p. 1
Biology and Cancer
Molecular Tools in Cancer Research	p. 3
Intracellular Signaling	p. 21
The Cellular Microenvironment and Metastases	p. 33
Control of the Cell Cycle	p. 49
Cell Life and Death	p. 67
Cancer Immunology	p. 77
Stem Cells, Cell Differentiation, and Cancer	p. 95
Vascular and Interstitital Biology of Tumors	p. 105
Genesis of Cancer
Environmental Factors	p. 125
DNA Damage Response Pathways and Cancer	p. 139
Viruses and Human Cancer	p. 153
Genetic Factors: Hereditary Cancer Predisposition Syndromes	p. 171
Genetic Factors: Finding Cancer Susceptibility Genes	p. 193
Progressing from Gene Mutations to Cancer	p. 207
Immunodeficiency and Cancer	p. 223
Diagnosing Cancer: Pathology and Laboratory Medicine
Principles of Oncologic Surgical Pathology	p. 233
Flow Cytometry in Oncologic Diagnosis	p. 241
Conventional and Molecular Cytogenetics of Neoplasia	p. 249
Molecular Diagnostics	p. 265
Biomarkers for Cancer Diagnostics	p. 277
Imaging	p. 283
Preventing and Treating Cancer
Biostatistics and Bioinformatlcs in Clinical Trials	p. 309
Structures Supporting Cancer Clinical Trials	p. 327
Economic Analysis of Cancer Treatment	p. 337
Use of Epidemiology in Oncology	p. 343
Cancer Prevention, Screening, and Early Detection	p. 361
Nicotine Dependence: Current Treatments and Future Directions	p. 397
Surgical Interventions in Cancer	p. 407
Basics of Radiation Therapy	p. 417
Systemic Therapy	p. 449
Principles of Molecularly Targeted Therapy: Present and Future	p. 485
Hematopoietic Stem Cell Transplantation	p. 501
Gene Therapy in Oncology	p. 513
Therapeutic Antibodies and Immunologic Conjugates	p. 531
Complementary and Alternative Medicine	p. 545
Problems Common to Cancer and its Therapy	p. 563
Symptom Management and Palliative Care
Cancer Pain	p. 565
Rehabilitation of Individuals with Cancer	p. 579
Cachexia	p. 591
Nausea and Vomiting	p. 599
Oral Complications	p. 609
Alopecia and Cutaneous Complications	p. 625
Lymphedema	p. 641
Fatigue	p. 657
Caring for Patients at the End of Life	p. 665
Hematologic Problems
Disorders of Blood Cell Production in Clinical Oncology	p. 677
Diagnosis, Treatment, and Prevention of Cancer-Related Venous Thrombosis	p. 693
Infections
Infection in the Patient with Cancer	p. 717
Metabolic and Paraneoplastic Syndromes
Hypercalcemia	p. 739
Hyponatremia	p. 749
Tumor Lysis Syndrome	p. 759
Paraneoplastic Neurologic Syndromes	p. 767
Surgical Problems
Establishing and Maintaining Vascular Access	p. 779
Acute Abdomen, Bowel Obstruction, and Fistula	p. 792
Local Effects of Cancer and Its Metastasis
Superior Vena Cava Syndrome	p. 803
Spinal Cord Compression	p. 815
Brain Metastases and Neoplastic Meningitis	p. 827
Bone Metastases	p. 845
Lung Metastases	p. 873
Liver Metastases	p. 885
Effusions	p. 925
Complications of Therapy
Neurologic Complications	p. 945
Pulmonary Complications of Anticancer Treatment	p. 969
Cardiac Effects of Cancer Therapy	p. 983
Reproductive Complications	p. 999
Endocrine Complications	p. 1013
Second Malignant Neoplasms	p. 1023
Special Populations
Cancer in the Elderly: Biology, Prevention, and Treatment	p. 1039
Special Issues in Pregnancy	p. 1049
HIV-Associated Malignancies	p. 1061
Specific Malignancies	p. 1073
Cancer of the Central Nervous System	p. 1075
Eye, Orbit, and Adnexal Structures	p. 1137
Cancer of the Head and Neck	p. 1177
Melanoma	p. 1229
Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas	p. 1253
Cancer of the Endocrine System	p. 1271
Cancer of the Lung: Non-Small Cell Lung Cancer	p. 1307
Tumors of the Pleura and Mediastinum	p. 1367
Cancer of the Esophagus	p. 1399
Cancer of the Stomach	p. 1431
Cancer of the Small Bowel	p. 1465
Colon Cancer	p. 1477
Cancer of the Rectum	p. 1535
Cancer of the Anal Canal	p. 1557
Liver and Bile Duct Cancer	p. 1569
Carcinoma of the Pancreas	p. 1595
Cancer of the Kidney	p. 1613
Carcinoma of the Bladder	p. 1635
Prostate Cancer	p. 1653
Cancer of the Penis	p. 1701
Testicular Cancer	p. 1713
Cancers of the Cervix, Vulva, and Vagina	p. 1745
Cancer of the Endometrium	p. 1793
Ovaries and Fallopian Tubes	p. 1827
Gestational Trophoblastic Disease	p. 1857
Cancer of the Breast	p. 1875
Sarcomas of Bone	p. 1945
Sarcomas of Soft Tissue	p. 2009
Carcinoma of Unknown Primary	p. 2057
Pediatric Solid Tumors	p. 2075
World Health Organization Classification of Hematologic Malignancies	p. 2131
Childhood Leukemia	p. 2139
Childhood Lymphoma	p. 2171
Acute Lymphocytic Leukemia in Adults	p. 2191
Acute Myeloid Leukemia in Adults	p. 2215
Myelodysplastic Syndromes	p. 2235
Myeloproliferative Disorders	p. 2261
Chronic Myeloid Leukemia	p. 2279
Chronic Lymphoid Leukemias	p. 2293
Hairy Cell Leukemia	p. 2309
Multiple Myeloma and Related Disorders	p. 2323
Hodgkin's Lymphoma	p. 2353
Non-Hodgkin's Lymphoma	p. 2371
Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma	p. 2405
Adult T-Cell Leukemia-Lymphoma	p. 2425
Index	p. 2443
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