The Activities of Bacterial Pathogens in Vivo

by Smith, Harry; Dorman, Charles J.; Dougan, G.; Holden, D. W.; Williams, P.

• ISBN13: 9781860942723
• ISBN10: 1860942725
• Format: Hardcover
• Copyright: 2001-12-01
• Publisher: Imperial College Pr

Summary

Describes the methods and shows how they, and a recent surge in conventional studies, are shedding light on the activities of bacterial pathogens in vivo. Discusses bacterial and host factors that operate in vivo to cause illness, showing how phenomena recognized in vitro relate to behavior in vivo, indicating how it might be obtained.

Table of Contents

Preface	v
Introduction
Questions about the Behaviour of Bacterial Pathogens in Vivo	3	(36)
H. Smith
DNA Topology and Adaptation of Salmonella typhimurium to an Intracellular Environment	39	(22)
D. G. Marshall
C. J. Dorman
F. Bowe
C. Hale
G. Dougan
New Methods for Studying Bacterial Behaviour in Vivo	61	(138)
The Pathogenesis of Shigella flexneri Infection: Lessons from in Vitro and in Vivo Studies	63	(32)
D. J. Philpott
J. D. Edgeworth
P. J. Sansonetti
Detection and Analysis of Gene Expression During Infection by in Vivo Expression Technology	95	(32)
D.S. Merrell
A. Camilli
Measurement of Bacterial Gene Expression in Vivo	127	(28)
I. Hautefort
J. C. D. Hinton
Identification and Analysis of Bacterial Virulence Genes in Vivo	155	(25)
K. E. Unsworth
D. W. Holden
Salmonella Interactions with Host Cells: In Vitro to in Vivo	180	(19)
B. B. Finlay
J. H. Brumell
Impact of the New Methods	199	(82)
In Vivo Gene Expression and the Adaptive Response: From Pathogenesis to Vaccines and Antimicrobials	201	(25)
D. M. Heithoff
R. L. Sinsheimer
D. A. Low
M. J. Mahan
Challenge of Investigating Biologically Relevant Functions of Virulence Factors in Bacterial Pathogens	226	(34)
R. Moxon
C. Tang
Virulence Gene Regulation Inside and Outside	260	(21)
V. J. DiRita
N. C. Engleberg
A. Heath
A. Miller
J. A. Crawford
R. Yu
Evidence for Operation in Vivo of Aspects of Pathogenicity Revealed by Recent Work in Vitro: Potential Use of New Methods	281	(114)
Quorum Sensing and the Population-dependent Control of Virulence	283	(34)
P. Williams
M. Camara
A. Hardman
S. Swift
V. J. Hope
K. Winzer
B. Middleton
D. I. Pritchard
B. W. Bycroft
D. Milton
Type III Secretion: A Bacterial Device for Close Combat with Cells of Their Eukaryotic Host	317	(32)
G. R. Cornelis
Evolution of Microbial Pathogens	349	(25)
J. Morschhauser
G. Kohler
W. Ziebuhr
G. Blum-Oehler
U. Dobrindt
J. Hacker
The Immune Responses to Bacterial Antigens Encountered in Vivo at Mucosal Surfaces	374	(21)
G. Dougan
M. Ghaem-Maghami
D. Pickard
G. Frankel
G. Douce
S. Clare
S. Dunstan
C. Simmons
Index	395