Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2006-07-20
  • Publisher: CRC Press

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An overview of how adenosine and inosine regulate immune responses, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases covers aspects of molecular biology, cell biology, and pharmacology. It addresses the role of adenosine receptors in regulating the function of various cell types involved in immune responses. It features data derived from studies using cutting-edge techniques. It discusses disease states such as autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. With contributions from international experts, the text is ideal for researchers in pharmaceutical companies, academic scientists, and clinicians

Table of Contents

Adenosine receptor pharmacologyp. 1
Medicinal chemistry of adenosine A[subscript 3] receptorsp. 15
The role of CD73 in the generation of extracellular adenosine for adenosine receptor signalingp. 39
Regulation of monocyte/macrophage function by adenosine receptorsp. 49
Impaired lymphocyte activation in the presence of adenosine : mechanisms and physiologic relevancep. 69
Adenosine and neutrophil functionsp. 89
Dendritic cells regulated by nucleotides and nucleosidesp. 101
Adenosine and endothelia cell functionp. 109
Adenosine A[subscript 2B] receptor in the intestinal epitheliap. 131
Adenosine, adenosine receptors, and the regulation of glial cells in neuronal damagep. 145
Adenosine receptors, wound healing, and angiogenesisp. 157
A[subscript 2A] adenosine receptors and ischemia reperfusion injuryp. 165
Adenosine signaling in chronic lung diseasep. 187
Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disordersp. 213
Anti-inflammatory and cytoprotective effects of inosinep. 237
Adenosine and infectionp. 257
Regulation of peripheral inflammation by spinal adenosinep. 285
Adenosine, tumors, and immunityp. 299
Adenosine in atherosclerosisp. 313
Regulation of macrophage-dependent angiogenesis by adenosine and toll-like receptorsp. 325
Table of Contents provided by Blackwell. All Rights Reserved.

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