9780879697846

Adult Neurogenesis

by
  • ISBN13:

    9780879697846

  • ISBN10:

    0879697849

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-11-15
  • Publisher: Cold Spring Harbor Laboratory Press

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Supplemental Materials

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Summary

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesisincludes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

Table of Contents

Prefacep. xi
Adult Neurogenesis: A Prologuep. 1
Methods
In vivo approaches
Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cellsp. 7
Detection and Phenotypic Characterization of Adult Neurogenesisp. 25
Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Reviewp. 49
The Use of Reporter Mouse Lines to Study Adult Neurogenesisp. 81
Retrovirus-mediated Cell Labelingp. 101
In vitro approaches
Neurospheresp. 119
Monolayer Cultures of Neural Stem/Progenitor Cellsp. 135
Basic Processes
Neurogenesis in the Adult Hippocampusp. 159
Adult Subventricular Zone and Olfactory Bulb Neurogenesisp. 175
Neurogenic Niches in the Adult Mammalian Brainp. 207
Molecular and Physiological Mechanisms
Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regionsp. 227
Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthoodp. 267
The Balance of Trophic Support and Cell Death in Adult Neurogenesisp. 283
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampusp. 299
Regulation
Genetics and Epigenetics in Adult Neurogenesisp. 321
Activity Dependency and Aging in the Regulation of Adult Neurogenesisp. 341
Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammationp. 363
Regulation of Adult Neurogenesis by Neurotransmittersp. 397
Functional Significance
Adult Neurogenesis in the Olfactory Bulbp. 425
Neurogenesis and Hippocampal Memory Systemp. 445
Computational Modeling of Adult Neurogenesisp. 463
Neurological Diseases
Hippocampal Neurogenesis: Depression and Antidepressant Responsep. 483
Adult Neurogenesis in Neurodegenerative Diseasep. 503
Epilepsy and Adult Neurogenesisp. 535
Neurogenesis following Stroke Affecting the Adult Brainp. 549
Comparative Neurogenesis
Adult Neurogenesis in Teleost Fishp. 571
Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Additionp. 593
Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements?p. 619
Adult Hippocampal Neurogenesis in Natural Populations of Mammalsp. 645
Indexp. 661
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