Advances in Genetics

by Hall; Dunlap; Friedmann; Giannelli

• ISBN13: 9780120176366
• ISBN10: 012017636X
• Edition: 1st
• Format: Hardcover
• Copyright: 1997-08-15
• Publisher: Elsevier Science

Summary

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms theAcademic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Table of Contents

Contributors	vii
The Peripheral Neuropathies and Their Molecular Genetics	1	(44)
C. Bell
N. Haites
Historical Introduction	2	(1)
Clinical Classification of CMT	2	(2)
Genetic Classification	4	(4)
Molecular Mechanisms in CMT1A	8	(11)
Molecular Mechanisms of CMT1B, DSD, and CMTX1	19	(2)
Myelin Proteins and Their Functional Significance	21	(13)
Molecular Diagnostic Testing for CMT and HNPP	34	(11)
References	36	(9)
Tumor Suppressor Genes and Human Cancer	45	(92)
Melissa A. Brown
Introduction	46	(7)
Tumor Suppressor Genes and Their Products	53	(41)
The Role of Tumor Suppressor Genes in Human Cancer	94	(11)
Conclusions	105	(32)
References	107	(30)
Genetic Redundancy	137	(20)
John F. Y. Brookfield
Introduction: The Evolutionary Background of Adaptation and Pleiotropy	138	(1)
Evidence for redundancy	139	(4)
Apparent and True Redundancy	143	(7)
The Organism and the Cell	150	(1)
Redundancy as a Fail-Safe System	151	(1)
Functional Redundancy	152	(1)
Conclusions	153	(4)
References	153	(4)
Genetics of Hybrid Inviability in Drosophila	157	(30)
Pierre Hutter
Introduction	157	(2)
Genetic Studies on Hybrid Inviability	159	(9)
Chromosomes and genes Influencing Hybrid Viability	168	(7)
Genetic Models for the Basis of Hybrid Inviability	175	(4)
Conclusions	179	(8)
References	181	(6)
Regulation of Bacterial Gene Expression by Metals	187	(52)
David J. Westenberg
Mary Lou Guerinot
Introduction	187	(3)
Essential Metals	190	(15)
Toxic Metals	205	(21)
Concluding Remarks	226	(13)
References	227	(12)
Chromosome Rearrangements in Neurospora and Other Filamentous Fungi	239	(160)
David D. Perkins
Introduction	241	(4)
General Information Regarding Neurospora Rearrangements	245	(11)
New Findings	256	(21)
Rearrangements in Other Fungi	277	(8)
Individual Chromosome Rearrangements of Neurospora crassa	285	(97)
Summary	382	(17)
References	383	(16)
Index	399