Advances in Vasopressin and Oxytocin - From Genes to Behaviour to Disease

by Landgraf; Neumann

• ISBN13: 9780444532015
• ISBN10: 0444532013
• eBook ISBN(s): 9780080932477, 9780444532015
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-09-10
• Publisher: Elsevier Science
• More Book Details
• Purchase Benefits

Summary

Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohypophysial system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike. . Comprehensive review of OXT and AVP physiology and behaviour . Each chapter covers a novel aspect of OXT and AVP research and is written by a leading expert . Review articles are ideal for experts and newcomers to the field alike . Discusses fascinating behavioural effects of oxytocin and vasopressin . Summarizes the recent explosion of neuropeptide research, physiology and behaviour, is in one location

Table of Contents

Vasopressin And Oxytocin in Evolution, Sexual Dichotomy and Stress

Nonapeptides and the evolutionary patterning of sociality

Sex differences in vasopressin and oxytocin innervation of the brain

The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress

Genetics Meets Behavior

Experimental approaches for the study of oxytocin and vasopressin gene expression in the central nervous system

Oxytocin knockout mice: a model for studying stress-related and ingestive behaviors

The role of the vasopressin 1b receptor in aggression and other social behaviors

Behavioral studies using temporal and spatial inactivation of the oxytocin receptor

New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

Regulation of Vasopressin and Oxytocin Release

Regulation of vasopressin release by co-released neurotransmitters: Mechanisms of purinergic and adrenergic synergism

Neuron-glia interactions in the rat supraoptic nucleus

Dynamic synapses in the hypothalamic-neurohypophyseal system

Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus

Oxytocin and appetite

Nonapeptide Receptors: Regulation and Signaling

Neural mechanisms underlying the milk ejection burst and reflex

Oxytocin receptor signalling

Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: it's all about oxytocin and progesterone receptors

Oxytocin receptors: ligand binding, signaling and cholesterol dependence

Neuronal Actions of Nonapeptides

Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response

Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons

Neurophysiology of supraoptic neurons in C57/BL mice studied in three acute in-vitro preparations

Effects of oxytocin on GABA signalling in the fetal brain during delivery

Regulation of Social Behaviors

Central vasopressin and oxytocin release: regulation of complex social behaviours

Interactions between dopamine and oxytocin in the control of sexual behaviour

Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety

Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin

Evolution of the arginine vasopressin 1 a receptor and implications for mammalian social behaviour

Oxytocin, vasopressin and sociality

Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans

Oxytocin And Vasopressin: Involvement in Stress Management

Chronic stress plasticity in the hypothalamic paraventricular nucleus

Keeping oxytocin neurons under control during stress in pregnancy

Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glycocorticoids

Vasopressin in the septum: not important versus causally involved in learning and memory

Two faces of the same coin? Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis

Psychopathology: Critical Involvement of the Vasopressin And Oxytocin Systems

Molecular genetic studies of the arginine vasopressin 1a receptor (AVPR1a) (and the oxytocin receptor (OXTR) in human behavior: from autism to altruism with some notes in between

Oxytocin and experimental therapeutics in autism spectrum disorders

Impact of prosocial neuropeptides on human brain function

Vasopressin and Oxytocin Agonists and Antagonists: From Pharmacology to Clinical Utility

Peptide and nonpeptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents

Affinity and efficacy of selective agonists and an

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