Advances in Virus Research

by Maramorosch, Karl

• ISBN13: 9780120398546
• ISBN10: 0120398540
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-10-01
• Publisher: ACADEMIC PRESS INC

Summary

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

Table of Contents

The Life and Times of Adenoviruses
Harold S. Ginsberg
Text	1	(11)
References	12	(3)
Role of Outer Capsid Proteins in Transmission of Phytoreovirus by Insect Vectors
Toshihiro Omura
Jin Yan
Introduction	15	(2)
Localization of Structural Proteins in Particles of Phytoreovirus	17	(1)
Role of P2 Protein in Viral Infection of Insect Vector Cells	18	(5)
Correlation between Infectivity and Presence of P2 Protein in RGDV	23	(4)
P2 Protein Allowing RDV to Adsorb to Insect Vector Cells	27	(4)
Absence of P2 Protein Expression in Transmission-Defective Isolate of RDV	31	(6)
P8 Outer Capsid Protein of RDV Involved in Viral Infection of Insect Vector Cells	37	(1)
Concluding Remarks	38	(7)
References	39	(6)
Replication of Human Hepatitis Delta Virus: Influence of Studies on Subviral Plant Pathogens
John M. Taylor
Introduction and Scope	45	(1)
Early History	46	(1)
Transmission, Epidemiology, and Pathogenesis	47	(1)
Initial Application of Molecular Virology	48	(1)
Initial Similarities to Plant Agents	49	(1)
Subsequent Molecular Virology	50	(4)
Subsequent Similarities to Plant Agents	54	(3)
Conclusions and Outlook	57	(4)
References	58	(3)
Regulation of Human Cytomegalovirus Gene Expression
Elizabeth A. Fortunato
Deborah H. Spector
Introduction	61	(2)
Viral Entry	63	(1)
Immediate Early Events Mediated by Initial Virus--Host Interaction	64	(5)
Utilization of Preexisting Nuclear Architecture by HCMV	69	(1)
Influence of Host Cell Cycle Phase on IE Gene Expression	69	(1)
Major Immediate Early Gene Expression IE1/IE2 (UL123/122)	70	(21)
Other IE Gene Products	91	(5)
Activation of Early Genes	96	(12)
Regulation of True Late Genes	108	(3)
Conclusions	111	(18)
References	112	(17)
DNA Vaccines: A Review
P. Jeff Lewis
Lorne A. Babiuk
DNA-Based Vaccines	129	(3)
Serum Kinetics and Uptake Mechanisms	132	(2)
Mechanism of Antigen Presentation	134	(5)
Adjuvancy Effects of Bacterially Derived DNA	139	(2)
Immune Response to DNA-Based Vaccines	141	(9)
Mucosal and Epidermal Delivery	150	(4)
Transdermal Delivery	154	(1)
Cytokine Modulation of Immunity to DNA-Based Vaccines	155	(9)
Safety	164	(4)
Future Directions	168	(7)
Summary	175	(14)
References	177	(12)
Epidemiological Risks from Mixed Virus Infections and Transgenic Plants Expressing Viral Genes
John Hammond
Herve Lecoq
Benjamin Raccah
Introduction	189	(3)
Mixed Infections	192	(39)
Transgenic Plants	231	(30)
Analysis of Risk and Proactive Risk Reduction	261	(22)
Concluding Remarks	283	(36)
References	289	(28)
Special Section: RESPIRATORY VIRUSES
Joseph L. Waner
Introduction
Joseph L. Waner
Text	317	(2)
Replication of Orthomyxoviruses
Agustin Portela
Thomas Zurcher
Amelia Nieto
Juan Ortin
Introduction	319	(1)
Ion Channel Protein	320	(4)
Return Ticket for RNP: Nucleocytoplasmic Transport of Influenza Genome	324	(4)
Transcription and Replication: Structure and Regulation of RNP Complex	328	(8)
Virus Assembly	336	(3)
Future Prospects	339	(10)
References	340	(9)
Influenza Vaccines: Present and Future
Kanta Subbarao
Introduction	349	(2)
Trivalent Inactivated Vaccine	351	(4)
Recombinant and Subunit Vaccines	355	(1)
Live Attenuated Influenza Vaccines	356	(6)
Future Developments in Vaccines	362	(2)
Summary	364	(11)
References	365	(10)
Influenza Neuraminidase as Target for Antivirals
Gillian M. Air
Anita A. Ghate
Stephen J. Stray
Introduction	375	(1)
Antiviral Agents	376	(9)
Structure-Based Drug Design	385	(6)
Concluding Remarks	391	(12)
References	397	(6)
Replication of Paramyxoviruses
Joseph Curran
Daniel Kolakofsky
Virion Structure and Genome Organization	403	(2)
Key Players	405	(8)
Supporting Cast	413	(3)
Genome Expression	416	(1)
Summary	417	(6)
References	418	(5)
Rational Design of Live-Attenuated Recombinant Vaccine Virus for Human Respiratory Syncytial Virus by Reverse Genetics
Peter L. Collins
Stephen S. Whitehead
Alexander Bukreyev
Rachel Fearns
Michael N. Teng
Katalin Juhasz
Robert M. Chanock
Brian R. Murphy
Introduction	423	(1)
Respiratory Syncytial Virus	424	(6)
RSV Disease	430	(1)
Immunity of RSV	431	(1)
Obstacles to Development of RSV Vaccine	432	(1)
RSV Reverse Genetics: Antigenic Subgroup A	433	(4)
Expression of Foreign Genes in Recombinant RSV	437	(1)
Gene Knockouts	438	(1)
Biologically Derived RSV Subgroup A Candidate Vaccine Viruses	439	(4)
Rational Design of Recombinant RSV Subgroup A Vaccine	443	(1)
Advantages of Recombinant DNA Method	444	(2)
Current Directions	446	(1)
Summary	446	(7)
References	447	(6)
Clinical Virology of Rhinoviruses
J. Owen Hendley
Introduction	453	(1)
Attributes of Virus and Epidemiology of Disease	454	(2)
Detection of Rhinovirus	456	(4)
Pathogenesis of Symptoms	460	(4)
Summary	464	(3)
References	465	(2)
Index	467