Ageing Vulnerability Causes and Interventions

by Bock, Gregory R.; Goode, Jamie A.

• ISBN13: 9780471494386
• ISBN10: 0471494380
• Additional ISBN(s): 9780787947552
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-03-30
• Publisher: WILEY
• More Book Details

Summary

With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as: age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.

Author Biography

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Table of Contents

Symposium on Ageing vulnerability: causes and interventions, held at the Novartis Foundation, London, 29 February--3 March 2000
Gregory Bock
Jamie A. Goode
This symposium is based on a proposal made by Gary Andrews. It was organized as a key component and in support of the United Nations Project `A Research Agenda on Ageing for the 21st Century'
Introduction	1	(3)
Thomas B. L. Kirkwood
The priority of basic research on ageing vulnerability in a comprehensive research agenda on ageing for the 21st century	4	(7)
Gary R. Andrews
Discussion	9	(2)
Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease?	11	(15)
Julie K. Andersen
Discussion	20	(6)
Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age related cataracts	26	(23)
Ashley I. Bush
Lee E. Goldstein
Discussion	38	(11)
General discussion I The role of glial cells in the ageing brain	44	(5)
Multiple substrates of late onset dementia: implications for brain protection	49	(17)
R. N. Kalaria
C. G. Ballard
P. G. Ince
R. A. Kenny
I. G. McKeith
C. M. Morris
J. T. O' Brien
E. K. Perry
R. H. Perry
J. A. Edwardson
Discussion	60	(6)
Ageing of murine small intestinal stem cells	66	(19)
C. S. Potten
K. Martin
T. B. L. Kirk wood
Discussion	79	(6)
Haematopoietic stem cells ageing	85	(20)
Amiela Globerson
Discussion	96	(9)
General discussion II	101	(4)
Identification of genes involved in cell senescence and immortalization: Potential implications for tissue ageing	105	(11)
James K. Leung
Olivia M. Pereira-Smith
Discussion	110	(6)
Ageing and cancer: the telomere and telomerase connection	116	(14)
Jerry W. Shay
Woodring E. Wright
Discussion	125	(5)
Ageing and the immune system	130	(20)
Rita B. Effros
Discussion	139	(11)
General discussion III	146	(4)
Mechanisms of age-related bone loss	150	(22)
Lis Mosekilde
Discussion	166	(6)
The old heart: operating on the edge	172	(30)
Edward G. Lakatta
Steven J. Sollott
Salvatore Pepe
Discussion	196	(6)
Pharmaceutical intervention of advanced glycation endproducts	202	(19)
Anthony Cerami
Peter Ulrich
Discussion	212	(9)
General discussion IV	217	(4)
The anti-ageing action of dietary restriction	221	(13)
Holly Van Remmen
Zhongmao Guo
Arlan Richardson
Discussion	230	(4)
Mitochondrial DNA mutations in disease and ageing	234	(13)
D. A. Cottrell
E. L. Blakely
M. A. Johnson
G. M. Borthwick
P. I. Ince
D. M. Turnbull
Discussion	243	(4)
A mitochondrial paradigm for degenerative diseases and ageing	247	(20)
Douglas C. Wallace
Discussion	263	(4)
Final discussion	267	(6)
Index of contributors	273	(2)
Subject index	275