Analytical Determination of Nicotine and Related Compounds and their Metabolites

by Gorrod; Jacob III

• ISBN13: 9780444500953
• ISBN10: 0444500952
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-11-02
• Publisher: Elsevier Science

Summary

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

Table of Contents

Foreword	v
Neal L. Benowitz
List of Contributors	ix
Pharmacological Significance of Nicotine	1	(12)
Edward F. Domino
Biosynthesis of Nicotine and Related Compounds	13	(32)
Lowell Bush
Walter Hempfling
Harold Burton
Biotransformation of Nicotine in Mammalian Systems	45	(24)
John W. Gorrod
Georg Schepers
Chemical Properties of Nicotine and Other Tobacco-Related Compounds	69	(80)
Peter A. Crooks
The Physical Chemistry of Nicotine	149	(42)
Joseph Banyasz
Use of Gas Chromatographic and Mass Spectrometric Techniques for the Determination of Nicotine and its Metabolites	191	(34)
Peyton Jacob, III
Gary D. Byrd
Use of High-Performance Liquid Chromatographic-Mass Spectrometric (LC-MS) Techniques for the Determination of Nicotine and its Metabolites	225	(40)
Peter A. Crooks
Gary D. Byrd
Use of Immunoassay Techniques for the Determination of Nicotine and its Metabolites	265	(20)
John J. Langone
Hilda B. Gjika
Helen Van Vunakis
Determination of Nicotine in Tobacco, Tobacco Processing Environments and Tobacco Products	285	(108)
Michael F. Borgerding
Thomas A. Perfetti
Suresh Ralapati
Determination of Nicotine in Pharmaceutical Products and Dietary Sources	393	(28)
Donald E. Leyden
Erich Leitner
Barbara Siegmund
Nitrosamines Derived from Nicotine and Other Tobacco Alkaloids	421	(68)
Stephen S. Hecht
Anthony R. Tricker
Determination of Nicotine in Mainstream and Sidestream Cigarette Smoke	489	(42)
Klaus Rustemeier
Jean-Jacques Piade
Nicotine in Environmental Tobacco Smoke	531	(52)
Michael W. Ogden
Roger A. Jenkins
Determination of Nicotine and its Metabolites in Biological Fluids: in vivo Studies	583	(62)
Riley A. Davis
Margareta Curvall
Determination of Nicotine and its Metabolites in Biological Fluids: in vitro Studies	645	(24)
Mui C. Tsai
John W. Gorrod
Uses and Abuses of Cotinine as a Marker of Tobacco Smoke Exposure	669	(52)
Peter N. Lee
Subject Index	721