Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

by Evans; G.O.

• ISBN13: 9780748403516
• ISBN10: 0748403515
• Format: Nonspecific Binding
• Copyright: 1996-04-29
• Publisher: CRC Press

Summary

presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity such as the liver, kidney and thyroid, the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.

Table of Contents

Preface	vii
Contributors	viii
General Introduction	1	(10)
G. O. Evans
Study Design and Regulatory Requirements	11	(10)
D. T. Davies
Preanalytical and Analytical Variables	21	(24)
J. Robinson
G. O. Evans
Preanalytical Variables	22	(10)
J. Robinson
G. O. Evans
Analytical Variables	32	(6)
J. Robinson
G. O. Evans
Analytical Interference	38	(7)
G. O. Evans
Statistical Approaches	45	(14)
A. Dickens
J. Robinson
General Enzymology	59	(12)
G. O. Evans
Assessment of Hepatotoxicity	71	(16)
D. D. Woodman
Assessment of Nephrotoxicity	87	(12)
M. D. Stonard
Assessment of Endocrine Toxicity	99	(38)
G. O. Evans
General Endocrinology	99	(6)
G. O. Evans
Thyroid Endocrinology	105	(18)
D. T. Davies
Other Endocrine Organs	123	(14)
G. O. Evans
Assessment of Gastrointestinal Toxicity and Pancreatic Toxicity	137	(10)
G. O. Evans
Assessment of Cardiotoxicity and Myotoxicity	147	(8)
G. O. Evans
Assessment of Neurotoxicity	155	(8)
M. D. Stonard
Electrolyte and Fluid Balance	163	(14)
M. J. York
G. O. Evans
Lipids	177	(10)
G. O. Evans
Proteins	187	(12)
G. O. Evans
Abbreviations	199	(2)
Appendix I SI Units and Conversion Tables	201	(3)
Appendix II General References for Animal Clinical Chemistry Data	204	(3)
Index	207