Antimicrobial Therapeutics Reviews The Bacterial Cell Wall as an Antibiotic Target

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  • Format: Paperback
  • Copyright: 2013-02-25
  • Publisher: Wiley-Blackwell
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Bacterial cell walls are unique structures that serve as ideal targets for antimicrobial drugs. Agents that interfere with bacterial cell wall biosynthesis or cell integrity have been used therapeutically with high efficacy and good safety since the 1940s.Because there is no comparable structure in mammalians, bacterial cell wall inhibitors can exhibit high target specificity with side effect profiles that are not target related, unlike some other classes of antibiotics. In addition, cell wall–active agents are frequently bactericidal in their action, providing the opportunity for complete bacterial clearance in serious infections.  In this Annals volume, the contributors explore the various roles of the bacterial cell wall as related to the physiology of bacteria and to the development of antibacterial drugs.

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Table of Contents

Introduction to Antimicrobial Therapeutics Reviews: The bacterial cell wall as an antimicrobial target v
Karen Bush

Recent trends in resistance to cell envelope – active antibacterial agents among key bacterial pathogens 1
Ronald N. master, Jennifer Deane, Carol Opiela and Daniel F. Sahm

The physiology of bacterial cell division 8
Alexander J. F. Egan and Waldemar Vollner

Viable screening targets related to the bacterial cell wall 29
Lynn L. Silver

Bacterial cell-wall recycling 54
Jarrod W. Johnson, Jed F. Fisher and Shahriar Mobashery

β-Lactam antimicrobials: what have you done for me lately? 76
George H. Talbot

Proliferation and significance of clinically relevant β-lactamases 84
Karen Bush

Metallo-β-lactamase structure and function 91
Timothy Palzkill

Newβ-lactam-β-lactamase inhibitor combinations in clinical development 105
David M. Shlaes

Siderophore conjugates 115
Malcolm G. P. Page

Peptide antimicrobials: cell wall as a bacterial target 127
Nannette Y. Yount and Michael R. Yeaman

Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall 139
Arnold S. Bayer, Tanja Schneider and Hans-Georg Sahl

Errata for Ann. N. Y. Acad. Sci. Volumes 1274 and 1275 159

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