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9780120790357

Antipsychotic Drugs and Their Side-Effects

by Barnes, T.R.
  • ISBN13:

    9780120790357

  • ISBN10:

    0120790351

  • eBook ISBN(s):

    9780120790357

  • Format: Hardcover
  • Copyright: 1997-10-01
  • Publisher: Academic Pr

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Summary

In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.

Table of Contents

Basic Science
The Pharmacology of the Phenothiazines, Butyrophenones, Thioxanthines, and Diphenylbutylpiperidines
The Pharmacology of Clozapine-Like Atypical Antipsychotics
Pharmacology and Clinical Properties of Selective Dopamine Antagonists, with Focus on Substituted Benzamides
Pre- and Postsynaptic D-1 to D-5 Dopamine Receptor Mechanisms in Relation to Antipsychotic Activity
Prediction of Antipsychotic Activity
Effects of Neuroleptics on Neuronal and Synaptic Structure
Brain Imaging and Antipsychotic Drugs
Pharmacokinetics of Antipsychotic Drugs. Clinical Issues
The Assessment of Antipsychotic Activity in Clinical Trials
Indications of Antipsychotic Drugs
Acute Treatment. J.M. Davis
Maintenance Treatment
Depot Neuroleptics
The Side Effects of Antipsychotic Drugs I: Neuropsychiatric Effects
The Side Effects of Antipsychotic Drugs II: Effects on Other Physiological Systems
Table of Contents provided by Publisher. All Rights Reserved.

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