Antithrombotic Therapy

by Becker, Richard; Fintel, Dan J.; Green, David

• ISBN13: 9781884735684
• ISBN10: 1884735681
• Edition: 2nd
• Format: Paperback
• Copyright: 2002-04-01
• Publisher: Professional Communications

Summary

Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice are reviewed.

Table of Contents

Physiology of Thrombosis

Role of Clotting Factors and Fibrinolysis in Thrombus Formation

Role of the Platelet

Antithrombotic Agents

Heparins, Selective Factor Xa Inhibitors, Direct Thrombin Inhibitors, and Warfarin

Plasminogen Activators

Fibrinolytic Agents

Antiplatelet Agents

Aspirin: Biology and Clinical Use

Ticlopidine

Clopidogrel

Platelet Glycoprotein IIb/IIIa Receptor Antagonists

Monitoring Therapy

Monitoring of Anticoagulants

Monitoring of Platelet Activity

Thrombotic Disorders

Inherited/Acquired Coagulation and Platelet Disorders (Thrombophilia)

Clinical Syndromes Arterial and Venous Diseases

Acute Coronary Syndromes

Acute Myocardial Infarction

Noncardiac Arterial Disease: Peripheral Arterial Vascular Disease and Stroke

Native and Prosthetic Valvular Heart Disease

Atrial Fibrillation

Venous Thromboembolic Disease and Pulmonary Embolism

Complications

Complications of Antithrombotic Therapy

Index

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