Apoptosis : Pharmacological Implications and Therapeutic Opportunities

by Kaufman, Scott H.

• ISBN13: 9780124023550
• ISBN10: 012402355X
• Format: Paperback
• Copyright: 1999-02-01
• Publisher: Academic Pr

Summary

Thematic volume for the serial on apoptosis and its role in pharmacological issues. The book also deals with therapeutic strategies, both experimental and currently in use. Expert editor with a stellar group of international authors. A very hot topic. Key Features * Provides a broad overview of the biology of PCD * Identifies important unanswered questions in the field * Discusses therapeutic possibilities suggested by current understanding of PCD pathways

Table of Contents

Contributors

Foreword

Biology of Cell Death

Apoptosis: An Overview of the Process and Its Relevance in Disease

Genetics of Apoptosis

Methods Utilized in the Study of Apoptosis

In Vitro Systems for the Study of Apoptosis

The Fas Pathway in Apoptosis

Ceramide: A Novel Lipid Mediator of Apoptosis

Control of Apoptosis by Proteases

Apoptosis under Physiologic Conditions

Death and Dying in the Immune System

Control of Apoptosis by Cytokines

Glucocorticoid-Induced Apoptosis

Apoptosis in Pathologic States

Apoptosis in AIDS

Virus-Induced Apoptosis

Apoptosis in Neurodegenerative Diseases

Apoptosis in the Mammalian Kidney: Incidence, Effectors, and Molecular Control in Normal Development and Disease States

Apoptosis in the Heart

Apoptosis and the Gastrointestinal System

Apoptosis in the Pathogenesis and Treatment of Cancer

Role of p53 in Apoptosis

Chemotherapy-Induced Apoptosis

Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer

Role of Bcr-Abl Kinase in Resistance to Apoptosis

Apoptosis in Hormone-Responsive Malignancies

Index

Contents of Previous Volumes

Table of Contents provided by Blackwell. All Rights Reserved.