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Preface | p. v |
Contributors | p. xi |
Introduction and Overview | p. xv |
Apoptosis and Alternative Modes of Cell Death | |
The Intrinsic Pathway of Apoptosis | p. 3 |
The Extrinsic Pathway of Apoptosis | p. 31 |
Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival | p. 55 |
Mitotic Catastrophe | p. 73 |
Autophagy and Autophagic Cell Death | p. 93 |
Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis | p. 109 |
Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis | |
Structure and Function of the Telomere | p. 125 |
Overview of Senescence | p. 145 |
Contributions of Telomerase to Tumorigenesis | p. 159 |
The Role of Telomeres in Genomic Instability | p. 173 |
DNA Damage Response, Signaling Pathways, and Tumorigenesis | |
Overview of the DNA Damage Checkpoint: ATM and ATR | p. 193 |
Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer | p. 223 |
Interplay Between [gamma]H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response | p. 243 |
DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy | p. 265 |
Resistance and Sensitization | |
Resistance/Signaling Pathways | p. 281 |
Ceramide and Multidrug Resistance | p. 299 |
Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling | p. 313 |
The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy | p. 335 |
Established Cancer Therapies | |
Antimetabolites | p. 361 |
Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexe | p. 383 |
Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death? | p. 407 |
The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs | p. 423 |
Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents | p. 465 |
Tyrosine Kinase Inhibitors | p. 477 |
Recent and Developing Cancer Therapies | |
Monoclonal Antibodies in Lymphomas | p. 511 |
Role of Apoptosis in Anti-Angiogenic Cancer Therapies | p. 537 |
Photodynamic Therapy-Induced Apoptosis | p. 557 |
Modulation of TRAIL Signaling for Cancer Therapy | p. 579 |
Index | p. 593 |
Table of Contents provided by Ingram. All Rights Reserved. |
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