Apoptosis, Sensescence, And Cancer

by Gewirtz, David A.; Holt, Shawn E.; Grant, Steven

• ISBN13: 9781588295279
• ISBN10: 1588295273
• Edition: 2nd
• Format: Hardcover
• Copyright: 2008-01-30
• Publisher: Humana Pr Inc

Summary

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death. The second is Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third is DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth is Resistance and Sensitization. The fifth covers Established Cancer Therapies, and the final section looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Table of Contents

Preface	p. v
Contributors	p. xi
Introduction and Overview	p. xv
Apoptosis and Alternative Modes of Cell Death
The Intrinsic Pathway of Apoptosis	p. 3
The Extrinsic Pathway of Apoptosis	p. 31
Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival	p. 55
Mitotic Catastrophe	p. 73
Autophagy and Autophagic Cell Death	p. 93
Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis	p. 109
Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis
Structure and Function of the Telomere	p. 125
Overview of Senescence	p. 145
Contributions of Telomerase to Tumorigenesis	p. 159
The Role of Telomeres in Genomic Instability	p. 173
DNA Damage Response, Signaling Pathways, and Tumorigenesis
Overview of the DNA Damage Checkpoint: ATM and ATR	p. 193
Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer	p. 223
Interplay Between [gamma]H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response	p. 243
DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy	p. 265
Resistance and Sensitization
Resistance/Signaling Pathways	p. 281
Ceramide and Multidrug Resistance	p. 299
Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling	p. 313
The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy	p. 335
Established Cancer Therapies
Antimetabolites	p. 361
Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexe	p. 383
Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death?	p. 407
The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs	p. 423
Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents	p. 465
Tyrosine Kinase Inhibitors	p. 477
Recent and Developing Cancer Therapies
Monoclonal Antibodies in Lymphomas	p. 511
Role of Apoptosis in Anti-Angiogenic Cancer Therapies	p. 537
Photodynamic Therapy-Induced Apoptosis	p. 557
Modulation of TRAIL Signaling for Cancer Therapy	p. 579
Index	p. 593
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