Apoptosis, Sensescence, And Cancer

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  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2008-01-30
  • Publisher: Humana Pr Inc

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Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death. The second is Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third is DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth is Resistance and Sensitization. The fifth covers Established Cancer Therapies, and the final section looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Table of Contents

Prefacep. v
Contributorsp. xi
Introduction and Overviewp. xv
Apoptosis and Alternative Modes of Cell Death
The Intrinsic Pathway of Apoptosisp. 3
The Extrinsic Pathway of Apoptosisp. 31
Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survivalp. 55
Mitotic Catastrophep. 73
Autophagy and Autophagic Cell Deathp. 93
Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasisp. 109
Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis
Structure and Function of the Telomerep. 125
Overview of Senescencep. 145
Contributions of Telomerase to Tumorigenesisp. 159
The Role of Telomeres in Genomic Instabilityp. 173
DNA Damage Response, Signaling Pathways, and Tumorigenesis
Overview of the DNA Damage Checkpoint: ATM and ATRp. 193
Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancerp. 223
Interplay Between [gamma]H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Responsep. 243
DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapyp. 265
Resistance and Sensitization
Resistance/Signaling Pathwaysp. 281
Ceramide and Multidrug Resistancep. 299
Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signalingp. 313
The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapyp. 335
Established Cancer Therapies
Antimetabolitesp. 361
Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexep. 383
Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death?p. 407
The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugsp. 423
Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agentsp. 465
Tyrosine Kinase Inhibitorsp. 477
Recent and Developing Cancer Therapies
Monoclonal Antibodies in Lymphomasp. 511
Role of Apoptosis in Anti-Angiogenic Cancer Therapiesp. 537
Photodynamic Therapy-Induced Apoptosisp. 557
Modulation of TRAIL Signaling for Cancer Therapyp. 579
Indexp. 593
Table of Contents provided by Ingram. All Rights Reserved.

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