Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition

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  • Edition: 6th
  • Format: Hardcover
  • Copyright: 5/2/2012
  • Publisher: McGraw-Hill Medical
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A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field's leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Editionprovides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that bestdescribe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalencyand unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic andbiopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokineticprinciples to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Table of Contents



1. Intrtoduction to Biopharmaceutics and Pharmacokinetics

2. Mathematical Fundamentals in Pharmacokinetics

3. One-compartment Open Model: Intravenous Bolus Administration 5. Intravenous Infusion

6. Drug Elimination and clearance

7. Pharmacokinetics of Oral Absorption

8. Multiple-Dosage Regimens

9. Monlinear Pharmacokinetics

10. Physiologic Drub Distribution and Protein Binding

11. Drug Elimination and Hepatic Clearance

12. Pharmacogenetics

13. Physioloic Factors Related to Drug Absorption

14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance

15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence

16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy

17. Modified-Release Drug Products

18. Targeted Drug Delivery Symptoms and Biotechnological Products

19. Relationship Between Pharmacokeinetics and Pharmacodynamics

20. Application of Pharmacokinetics to Clinical Situations

21. Dose Adjustment in Renal and Hepatic Disease Appendix A Statistics

Appendix B Applications of Computer in Pharmacokinetcs

Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions

Appendix D Guiding Prinicples for Human and Animal Research

Appendix E Popular Drugs and Pharmacokinetic Parameters


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