Autism

by Zimmerman, Andrew W.

• ISBN13: 9781603274883
• ISBN10: 160327488X
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-10-15
• Publisher: Humana Pr Inc

Summary

"Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine."--BOOK JACKET.

Table of Contents

Molecular and Clinical Genetics	p. 1
ENGRAILED2 and Cerebellar Development in the Pathogenesis of Autism Spectrum Disorders	p. 3
Teratogenic Alleles in Autism and Other Neurodevelopmental Disorders	p. 41
Cholesterol Deficit in Autism: Insights from Smith-Lemli-Opitz Syndrome	p. 69
Autism in Genetic Intellectual Disability Insights into Idiopathic Autism	p. 81
Neurotransmitters and Cell Signaling	p. 109
Serotonin Dysfunction in Autism	p. 111
Excitotoxicity in Autism The Role of Glutamate in Pathogenesis and Treatment	p. 133
Prenatal ß2-Adrenergic Receptor Signaling and Autism: Dysmaturation and Retained Fetal Function	p. 147
Endocrinology, Growth, and Metabolism	p. 183
A Role for Fetal Testosterone in Human Sex Differences Implications for Understanding Autism	p. 185
Interaction between Genetic Vulnerability and Neurosteroids in Purkinje cells as a Possible Neurobiological Mechanism in Autism Spectrum Disorders	p. 209
Insulin-Like Growth Factors Neurobiological Regulators of Brain Growth in Autism?	p. 233
Oxidative Strees and the Metabolic Pathology of Autism	p. 245
Immunology, Maternal-Fetal Interaction, and Neuroinflammation	p. 269
The Immune System in Autism Is There a Connection?	p. 271
Maternal Immune Activation, Cytokines and Autism	p. 289
Maternal Antibodies and the Placental-Fetal IgG Transfer Theory	p. 309
Can Neuroinflammation Influence the Development of Autism Spectrum Disorders?	p. 329
Neuroanatomy and Neural networks	p. 347
The Significance of Minicolumnar Size Variability in Autism A Perspective from Comparative Anatomy	p. 349
Imaging Evidence for Pathological Brain Development in Autism Spectrum Disorders	p. 361
Information Processing, Neural Connectivity, and Neuronal Organization	p. 381
Environmental Mechanisms and Models	p. 407
Evidence for Environmental Susceptibility in Autism What We Need to Know About Gene x Environment Interactions	p. 409
An Expanding Spectrum of Autism Models From Fixed Developmental Defects to Reversible Functional Impairments	p. 429
Index	p. 465
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