Bioinformatics and Functional Genomics

by Jonathan Pevsner (Department of Neurology, Kennedy Krieger Institute and Department of Neuroscience and Division of Health Sciences Informatics, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA)

• ISBN13: 9780471210047
• ISBN10: 0471210048
• Format: Paperback
• Copyright: 2003-11-01
• Publisher: Wiley-Liss

Summary

Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.

Author Biography

Jonathan Pevsner: Department of Neurology, Kennedy Krieger Institute and Department of Neuroscience and Division of Health Sciences Informatics, The Johns Hopkins School of Medicine, Baltimore, Maryland

Table of Contents

PART 1. ANALYZING DNA, RNA, AND PROTEIN SEQUENCES IN DATABASES.

Chapter 1. Introduction.

Chapter 2. Access to Sequence and Literature Databases.

Chapter 3. Pairwise Sequence Alignment.

Chapter 4. Basic Local Alignmnet Search Tool (BLAST).

Chapter 5. Advanced BLAST Searching.

PART 2. GENOME-WIDE ANALYSIS OF RNA AND PROTEIN.

Chapter 6. Genome-wide Analysis of Gene Expression.

Chapter 7. Gene Expression: Microarrays.

Chapter 8. Protein Analysis and Proteomics.

Chapter 9. Protein Structure.

Chapter 10. Multiple Sequence Alignment.

Chapter 11. Molecular Phylogeny.

PART 3. GENOME ANALYSIS.

Chapter 12. Completed Genomes and the Tree of Life.

Chapter 13. Completed Genomes: Viruses.

Cchapter 14. Completed Genomes: Bacteria and Archaea.

Chapter 15. Eukaryotic Genomes: Fungi

Chapter 16. Eukaryotic Genomes: From Parasites to Primates.

Chapter 17. The Human Genome.

Chapter 18. Human Disease.

Chapter 19. Conclusions.

Appendix 1. GCG for Protein and DNA Analysis.

Glossary.

Index.

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