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| Exercise Limitations | p. 1 |
| Introduction | p. 1 |
| Exercise Intensity and Duration | p. 3 |
| Muscle Metabolism | p. 10 |
| Muscle Fiber Structure | p. 10 |
| Muscle Energy Sources | p. 11 |
| Oxygen Debt | p. 14 |
| Maximal Oxygen Uptake | p. 17 |
| Anaerobic Threshold | p. 26 |
| Oxygen Uptake Kinetics | p. 30 |
| A Bioenergetics Model | p. 39 |
| Chemical Responses | p. 41 |
| Training | p. 42 |
| Cardiovascular Exercise Limitation | p. 42 |
| Respiratory Limitation | p. 44 |
| Thermal Limitation | p. 45 |
| Prolonged Exercise | p. 45 |
| Variability of Responses | p. 47 |
| Symbols | p. 48 |
| Homework Problems | p. 49 |
| References | p. 53 |
| Exercise Biomechanics | p. 57 |
| Introduction | p. 57 |
| Physics of Movement | p. 57 |
| Equilibrium and Stability | p. 57 |
| Muscles and Levers | p. 60 |
| Energy and Motion | p. 63 |
| Translational Motion | p. 63 |
| Angular Motion | p. 70 |
| The Energy Cost of Movement | p. 76 |
| Cost of Transport | p. 76 |
| Muscular Efficiency | p. 79 |
| Walking and Running | p. 82 |
| Basic Analysis | p. 82 |
| Optimal Control of Walking | p. 86 |
| Experimental Results | p. 93 |
| Carrying Loads | p. 95 |
| Load Position | p. 96 |
| Lifting and Carrying | p. 97 |
| Biomechanical Model | p. 98 |
| Using Carts | p. 100 |
| Sustained Work | p. 104 |
| Aging and Training | p. 106 |
| Gender | p. 107 |
| Genetics | p. 107 |
| Symbols | p. 108 |
| Homework Problems | p. 109 |
| References | p. 113 |
| Cardiovascular Responses | p. 117 |
| Introduction | p. 117 |
| Cardiovascular Mechanics | p. 118 |
| Blood Characteristics | p. 118 |
| Composition | p. 118 |
| Oxygen-Carrying Capacity | p. 118 |
| Carbon Dioxide Transport | p. 124 |
| Viscosity | p. 125 |
| Vascular Characteristics | p. 133 |
| Organization | p. 133 |
| Resistance | p. 134 |
| Very Small Vessels | p. 136 |
| Heart Characteristics | p. 146 |
| Starling's Law | p. 147 |
| Blood Pressure | p. 148 |
| Heart Rate | p. 150 |
| Cardiac Output | p. 152 |
| Energetics | p. 155 |
| Cardiovascular Control | p. 160 |
| Neural Regulation | p. 161 |
| Sensors | p. 161 |
| Controller | p. 162 |
| Effector Organs | p. 166 |
| Reflexes | p. 166 |
| Humoral Regulation | p. 171 |
| Other Regulatory Effects | p. 172 |
| Exercise | p. 172 |
| Heat and Cold Stress | p. 175 |
| Cardiovascular Mechanical Models | p. 176 |
| Robinson's Ventricle Model | p. 177 |
| Comprehensive Circulatory System Model | p. 183 |
| Vascular System Models | p. 184 |
| Transmission Line Analogs | p. 184 |
| Two Compartment Model | p. 184 |
| Fractal Vascularity | p. 184 |
| Model of Pulmonary Hemorrhage | p. 186 |
| Optimization Models | p. 189 |
| Heart Rate Models | p. 198 |
| Transient Response | p. 198 |
| Heat Effects | p. 200 |
| Comparison between the Two Heart Rate Models | p. 204 |
| Cardiovascular Control Models | p. 205 |
| The Heart | p. 206 |
| The Ventricles | p. 206 |
| The Atria | p. 212 |
| Heart Rate Control | p. 214 |
| Coronary Blood Flow and Heart Performance | p. 216 |
| Systemic and Pulmonary Vessels | p. 218 |
| Mechanics | p. 218 |
| Vascular Resistance Control | p. 221 |
| Control of Capillary Pressure and Blood Volume | p. 221 |
| Nonlinear Resistances | p. 222 |
| Model Performance | p. 225 |
| Numerically Solving Differential Equations | p. 226 |
| Approximations to Derivatives | p. 226 |
| Integral Equations | p. 227 |
| Initial Values | p. 227 |
| Time Step | p. 228 |
| Pontryagin Maximum Principle | p. 229 |
| The Laplace Transform | p. 232 |
| Symbols | p. 234 |
| Homework Problems | p. 239 |
| References | p. 247 |
| Respiratory Responses | p. 253 |
| Introduction | p. 253 |
| Respiratory Mechanics | p. 254 |
| Respiratory Anatomy | p. 254 |
| Lungs | p. 255 |
| Conducting Airways | p. 255 |
| Alveoli | p. 260 |
| Pulmonary Circulation | p. 262 |
| Respiratory Muscles | p. 263 |
| Lung Volumes and Gas Exchange | p. 267 |
| Lung Volumes | p. 267 |
| Perfusion of the Lung | p. 269 |
| Gas Partial Pressures | p. 271 |
| Respiratory Exchange Ratio | p. 274 |
| Lung Diffusion | p. 278 |
| Gas Mixing in the Airways | p. 282 |
| Diffusion Capacity | p. 284 |
| Blood Gases | p. 286 |
| Pulmonary Gas Exchange | p. 288 |
| Mechanical Properties | p. 295 |
| Respiratory System Models | p. 295 |
| Resistance | p. 298 |
| Compliance | p. 313 |
| Inertance | p. 318 |
| Natural Frequency | p. 318 |
| Time Constant | p. 319 |
| Muscle Pressures | p. 320 |
| Respiratory Work | p. 321 |
| Control of Respiration | p. 327 |
| Respiratory Receptors | p. 330 |
| Chemoreceptors | p. 330 |
| Mechanoreceptors | p. 335 |
| Other Inputs | p. 337 |
| Respiratory Controller | p. 337 |
| Respiratory Rhythm | p. 337 |
| Airflow Waveshape | p. 339 |
| Control Signals | p. 344 |
| Effector Organs | p. 345 |
| Respiratory Muscles | p. 345 |
| Airway Muscles | p. 346 |
| Local Effectors | p. 346 |
| Exercise | p. 346 |
| Initial Rise | p. 347 |
| Transient Increase | p. 348 |
| Steady State | p. 349 |
| Cessation of Exercise | p. 357 |
| Anaerobic Ventilation | p. 358 |
| Peak Flow | p. 360 |
| Ventilatory Loading | p. 361 |
| Dyspnea and Second Wind | p. 366 |
| Optimization of Breathing | p. 369 |
| Summary of Control Theories | p. 380 |
| Respiratory Mechanical Models | p. 386 |
| Respiratory Mechanics Models | p. 386 |
| Jackson-Milhorn Computer Model | p. 386 |
| Expiratory Flow Model | p. 397 |
| Ventilation Distribution Model with Nonlinear Components | p. 402 |
| Theory of Resistive Load Detection | p. 406 |
| Gas Concentration Models | p. 414 |
| Concentration Dynamics Model | p. 414 |
| Respiratory Control Models | p. 422 |
| System Models | p. 422 |
| Grodins Model | p. 422 |
| Saunders Modification of Grodins Model | p. 433 |
| Topor et al. Modification of Grodins Model | p. 441 |
| Yamamoto CO[subscript 2] Model | p. 446 |
| Fujihara Control Model | p. 458 |
| Optimization Models | p. 461 |
| Yamashiro and Grodins Model | p. 461 |
| Hamalainen Model | p. 465 |
| The Change in Initial Lung Volume during Exercise | p. 471 |
| Respiratory Work Rate | p. 473 |
| Brief Discussion of Respiratory Control Models | p. 478 |
| Lagrange Multipliers | p. 479 |
| Method of Calculus of Variations | p. 480 |
| Symbols | p. 482 |
| Homework Problems | p. 490 |
| References | p. 501 |
| Thermal Responses | p. 513 |
| Introduction | p. 513 |
| Passive Heat Loss | p. 513 |
| Active Responses | p. 515 |
| Thermal Mechanics | p. 516 |
| Convection | p. 517 |
| Body Surface Area | p. 519 |
| Respiratory Convective Heat Loss | p. 520 |
| Conduction | p. 524 |
| Clothing | p. 525 |
| Mean Skin Temperature | p. 527 |
| Radiation | p. 530 |
| Radiant Heat Transfer Coefficient | p. 532 |
| Solar Heat Load | p. 534 |
| Evaporation | p. 541 |
| Respiratory Evaporation | p. 544 |
| Sweating | p. 545 |
| Clothing | p. 546 |
| Rate of Heat Production | p. 557 |
| Basal Metabolic Rate | p. 557 |
| Food Ingestion | p. 560 |
| Muscular Activity | p. 561 |
| Rate of Change of Stored Heat | p. 570 |
| Thermoregulation | p. 575 |
| Thermoreceptors | p. 575 |
| Hypothalamus | p. 576 |
| Heat Loss Mechanisms | p. 581 |
| Vasodilation | p. 581 |
| Sweating | p. 584 |
| Heat Maintenance and Generation | p. 587 |
| Vascular Responses | p. 587 |
| Shivering | p. 589 |
| Nonshivering Thermogenesis | p. 589 |
| Acclimatization | p. 590 |
| Circadian Rhythm | p. 591 |
| Exercise and Thermoregulation | p. 592 |
| Thermoregulatory Models | p. 593 |
| Cylindrical Models | p. 593 |
| Gagge Model | p. 593 |
| Wyndham-Atkins Model | p. 597 |
| Multicompartment Model | p. 605 |
| External Thermoregulation | p. 614 |
| Body Temperature Response | p. 616 |
| Equilibrium Temperature | p. 616 |
| Metabolic Heat Load | p. 617 |
| Radiation and Convection Heat Exchange | p. 619 |
| Sweating | p. 620 |
| Equilibrium Body Temperature | p. 621 |
| Variation of Rectal Temperature with Time | p. 621 |
| Changes at Rest Under Heat Stress | p. 621 |
| Elevation during Work | p. 621 |
| Recovery after Work | p. 622 |
| Effect of Acclimatization | p. 623 |
| Model Limitations and Performance | p. 624 |
| Symbols | p. 631 |
| Homework Problems | p. 634 |
| References | p. 641 |
| Index | p. 649 |
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