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Preface to the fourth edition | p. v |
Informational macromolecules | |
Information processing and molecular biology | p. 1 |
Nucleic acid structure and function | p. 4 |
Protein structure and function | p. 12 |
Macromolecular assemblies | p. 22 |
Analysis of proteins | p. 26 |
Properties of nucleic acids | |
Chemical and physical properties of nucleic acids | p. 33 |
Spectroscopic and thermal properties of nucleic acids | p. 37 |
DNA supercoiling | p. 40 |
Prokaryotic and eukaryotic chromosome structure | |
Prokaryotic chromosome structure | p. 45 |
Chromatin structure | p. 48 |
Eukaryotic chromosome structure | p. 53 |
Genome complexity | p. 59 |
DNA replication | |
DNA replication: an overview | p. 64 |
Bacterial DNA replication | p. 69 |
Eukaryotic DNA replication | p. 74 |
DNA damage, repair, and recombination | |
DNA damage | p. 78 |
Mutagenesis | p. 82 |
DNA repair | p. 86 |
Recombination and transposition | p. 91 |
Transcription in bacteria | |
Basic principles of transcription | p. 96 |
Escherichia coli RNA polymerase | p. 99 |
The E. coli ¿70 promoter | p. 102 |
Transcription initiation, elongation, and termination | p. 105 |
Regulation of transcription in bacteria | |
The lac operon | p. 110 |
The trp operon | p. 114 |
Transcriptional regulation by alternative a factors and RNA | p. 119 |
Transcription in eukaryotes | |
The three RNA polymerases: characterization and function | p. 123 |
RNA Pol I genes: the ribosomal repeat | p. 126 |
RNA Pol III genes: 5S and tRNA transcription | p. 130 |
RNA Pol II genes: promoters and enhancers | p. 134 |
General transcription factors and RNA Pol II initiation | p. 137 |
Regulation of transcription in eukaryotes | |
Eukaryotic transcription factors | p. 141 |
Examples of transcriptional regulation | p. 148 |
RNA processing and RNPs | |
rRNA processing and ribosomes | p. 154 |
tRNA and other small RNA processing | p. 160 |
mRNA processing, hnRNPs, and snRNPs | p. 164 |
Alternative mRNA processing | p. 171 |
The genetic code and tRNA | |
The genetic code | p. 176 |
tRNA structure and function | p. 181 |
Protein synthesis | |
Aspects of protein synthesis | p. 188 |
Mechanism of protein synthesis | p. 192 |
Initiation in eukaryotes | p. 199 |
Translational control and post-translational events | p. 204 |
Bacteriophages and eukaryotic viruses | |
Introduction to viruses | p. 210 |
Bacteriophages | p. 213 |
DNA viruses | p. 218 |
RNA viruses | p. 222 |
Cell cycle and cancer | |
The cell cycle | p. 226 |
Oncogenes | p. 231 |
Tumor suppressor genes | p. 236 |
Apoptosis | p. 240 |
Gene manipulation | |
DNA cloning: an overview | p. 244 |
Preparation of plasmid DNA | p. 249 |
Restriction enzymes and electrophoresis | p. 253 |
Ligation, transformation, and analysis of recombinants | p. 258 |
Cloning vectors | |
Design of plasmid vectors | p. 265 |
Bacteriophages, cosmids, YACs, and BACs | p. 270 |
Eukaryotic vectors | p. 278 |
Gene libraries and screening | |
Genomic libraries | p. 283 |
cDNA libraries | p. 286 |
Screening procedures | p. 290 |
Analysis and uses of cloned DNA | |
Characterization of clones | p. 293 |
Nucleic acid sequencing | p. 297 |
Polymerase chain reaction | p. 303 |
Analysis of cloned genes | p. 309 |
Mutagenesis of cloned genes | p. 313 |
Functional genomics and the new technologies | |
Introduction to the 'omics | p. 317 |
Global gene expression analysis | p. 321 |
Proteomics | p. 328 |
Cell and molecular imaging | p. 333 |
Transgenics and stem cell technology | p. 337 |
Bioinformatics | p. 341 |
Systems and synthetic biology | p. 350 |
Further reading | p. 356 |
Abbreviations | p. 365 |
Index | p. 368 |
Table of Contents provided by Ingram. All Rights Reserved. |
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.