Brain Injury

by Clark, Robert S. B., M.D.; Kochanek, Patrick, M.D.

• ISBN13: 9780792375326
• ISBN10: 0792375327
• Format: Hardcover
• Copyright: 2001-11-01
• Publisher: Kluwer Academic Pub

Summary

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Table of Contents

Foreword	vii
Preface	ix
Contributors	xi
Excitotoxic Damage in Traumatic Brain Injury	1	(36)
Oscar L. Alves
Ross Bullock
The Multifaceted Role of Adenosine in Experimental and Clinical Traumatic Brain Injury	37	(20)
Patrick M. Kochanek
Edwin K. Jackson
Preconditioning	57	(14)
Michael J. Bell
John M. Hallenbeck
Molecular and Cellular Mechanisms of Traumatic Cerebral Vascular Injury	71	(28)
Douglas S. DeWitt
Donald S. Prough
Inflammatory Response to Brain Injury	99	(16)
Maria Cristina Morganti-Kossmann
Mario Rancan
Philip F. Stahel
Viviane I. Otto
Thomas Kossmann
Free Radicals and Acute Brain Injury: Mechanisms of Oxidative Stress and Therapeutic Potentials	115	(30)
Hulya Bayr
Valerian E. Kagan
Mitochondria in Acute Brain Injury	145	(18)
Yong Y. Han
Ian J. Reynolds
Cell Signaling: Serine/Threonine Protein Kinases and Traumatic Brain Injury	163	(18)
Larry Jenkins
C. Edward Dixon
Grant Peters
Wei-Min Gao
Xiaopeng Zhang
P. David Adelson
Patrick M. Kochanek
Death Receptors in Acute Brain Injury	181	(18)
Michael J. Whalen
Michael A. Moskowitz
Apoptosis	199	(32)
Xiaopeng Zhang
Margaret A. Satchell
Robert S. D. Clark
Paula D. Nathaniel
Patrick M. Kochanek
Steven H. Graham
Ischemia-Induced Ionic Mechanisms of Injury in the Developing Brain	231	(18)
Robert C. Tasker
Neurocytoskeletal Changes Following Traumatic Brain Injury	249	(18)
Jimmy W. Huh
Tracy K. McIntosh
Mark A. Helfaer
Kathryn E. Saatman
Neurotransmitter and Growth Factor Alterations in Functional Deficits and Recovery Following Traumatic Brain Injury	267	(28)
Anthony E. Kline
Larry W. Jenkins
Hong Q. Yan
C. Edward Dixon
Reproductive Hormones as Neuroprotectants in Brain Injury	295	(22)
Nabil J. Alkayed
Michael M. Wang
Patricia D. Hurn
Role of Genetic Background: Influence of Apolipoprotein e Genotype in Alzheimer's Disease and After Head Injury	317	(32)
Mary E. Kerr
Steven T. DeKosky
Andrew Kay
Donald W. Marion
Anesthetics and the Injured Brain	349	(20)
David S. Warner
Index	369