The Cardiovascular System Cold Spring Harbor Symposia on Quantitative Biology, Volume LXVII

• ISBN13: 9780879696795
• ISBN10: 0879696796
• Edition: 1st
• Format: Paperback
• Copyright: 2003-05-30
• Publisher: Cold Spring Harbor Laboratory Press
• More Book Details
• Purchase Benefits

Summary

Normal cardiovascular function requires the concerted action of many cell types, each capable of adaptive gene expression in response to developmental, physiological, and pathological cues. The genetic basis of cardiovascular function, development, and disease is an area of intense investigation, in the hope of significant insights into the heart and vessels' basic workings and improvements in diagnosis and therapy. This latest volume in a prestigious book series presents a remarkable survey of current progress in these efforts, through the contributions of over fifty of the world's leading investigators. Sections are devoted to angiogenesis, cardiogenesis, homeostasis, development, vascular biology, and cardiovascular repair and therapy. The book is an essential source of ideas, discoveries, and references for clinical scientists and physicians interested in basic cardiac biology, hypertension, atherosclerosis, coronary artery disease, and heart failure.

Table of Contents

Symposium Participants	v
Foreword	xvii
Development of the Cardiovascular System
Cardiogenesis in the Drosophila Model: Control Mechanisms during Early Induction and Diversification of Cardiac Progenitors	1	(12)
S. Zaffran
X. Xu
P.C.H. Lo
H.-H. Lee
M. Frasch
Regulation of Cardiac Muscle Differentiation in Xenopus laevis Embryos	13	(6)
T. Mohun
B. Latinkic
N. Towers
S. Kotecha
Genetic Regulation of Cardiac Patterning in Zebrafish	19	(8)
D. Yelon
J.L. Feldman
B.R. Keegan
Zebrafish Hearts and Minds: Nodal Signaling in Cardiac and Neural Left-Right Asymmetry	27	(10)
S. Long
N. Ahmad
M. Rebagliati
Cardiac Left-Right Development: Are the Early Steps Conserved?	37	(8)
K.L. Kramer
H.J. Yost
Erythropoietin and Retinoic Acid Signaling in the Epicardium Is Required for Cardiac Myocyte Proliferation	45	(4)
I. Stuckmann
A.B. Lassar
Endocardial Cushion Formation in Zebrafish	49	(8)
D.Y.R. Stainier
D. Beis
B. Jungblut
T. Bartman
Neural Crest Migration and Mouse Models of Congenital Heart Disease	57	(6)
A.D. Gitler
C.B. Brown
L. Kochilas
J. Li
J.A. Epstein
Transcription Factors in Cardiovascular Development
Hey bHLH Factors in Cardiovascular Development	63	(8)
A. Fischer
C. Leimeister
C. Winkler
N. Schumacher
B. Klamt
H. Elmasri
C. Steidl
M. Maier
K.-P. Knobeloch
K. Amann
A. Helisch
M. Sendtner
M. Gessler
Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter	71	(10)
E.M. Small
P.A. Krieg
Pitx Genes during Cardiovascular Development	81	(8)
C. Kioussi
P. Briata
S.H. Baek
A. Wynshaw-Boris
D.W. Rose
M.G. Rosenfeld
Pitx2 and Cardiac Development: A Molecular Link between Left/Right Signaling and Congenital Heart Disease	89	(8)
M. Campione
L. Acosta
S. Martinez
J.M. Icardo
A. Aranega
D. Franco
Regulation of Cardiac Growth and Development by SRF and Its Cofactors	97	(10)
D. Wang
R. Passier
Z.-P. Liu
C.H. Shin
Z. Wang
S. Li
L.B. Sutherland
E. Small
P.A. Krieg
E.N. Olson
Homeodomain Factor Nkx2-5 in Heart Development and Disease	107	(8)
R.P. Harvey
D. Lai
D. Elliott
C. Biben
M. Solloway
O. Prall
F. Stennard
A. Schindeler
N. Groves
L. Lavulo
C. Hyun
T. Yeoh
M. Costa
M. Furtado
E. Kirk
Causes of Clinical Diversity in Human TBX5 Mutations	115	(6)
T. Huang
J.E. Lock
A.C. Marshall
C. Basson
J.G. Seidman
C.E. Seidman
Molecular Mechanisms of Ventricular Hypoplasia	121	(6)
D. Srivastava
P.D. Gottlieb
E.N. Olson
Hypoxia, HIFs, and Cardiovascular Development	127	(6)
M.C. Simon
D. Ramirez-Bergeron
F. Mack
C.-J. Hu
Y. Pan
K. Mansfield
Quiescent Hypervascularity Mediated by Gain of HIF-1α Function	133	(10)
J.M. Arbeit
Vascular Biology
The Diverse Roles of Integrins and Their Ligands in Angiogenesis	143	(12)
R.O. Hynes
J.C. Lively
J.H. McCarty
D. Taverna
S.E. Francis
K. Hodivala-Dilke
Q. Xiao
Arteries, Veins, Notch, and VEGF	155	(8)
B.M. Weinstein
N.D. Lawson
Cell Cycle Signaling and Cardiovascular Disease	163	(8)
E.G. Nabel
M. Boehm
L.M. Akyurek
T. Yoshimoto
M.F. Crook
M. Olive
H. San
X. Qu
Selective Functions of Angiopoietins and Vascular Endothelial Growth Factor on Blood Vessels: The Concept of ``Vascular Domain''	171	(10)
T.N. Sato
S. Loughna
E.C. Davis
R.P. Visconti
C.D. Richardson
Survival Mechanisms of VEGF and PIGF during Microvascular Remodeling	181	(8)
J.N. Upalakalin
I. Hemo
C. Dehio
E. Keshet
L.E. Benjamin
Molecular Mechanisms of Lymphangiogenesis	189	(8)
T. Makinen
K. Alitalo
Protease-activated Receptors in the Cardiovascular System	197	(12)
S.R. Coughlin
Migration of Monocytes/Macrophages In Vitro and In Vivo Is Accompanied by MMP12-dependent Tunnel Formation and by Neovascularization	209	(8)
M. Anghelina
A. Schmeisser
P. Krishnan
L. Moldovan
R.H. Strasser
N.I. Moldovan
The Role of EG-VEGF in the Regulation of Angiogenesis in Endocrine Glands	217	(6)
J. LeCouter
R. Lin
N. Ferrara
Profiling the Molecular Diversity of Blood Vessels	223	(4)
R. Pasqualini
W. Arap
Tumor Angiogenesis
VEGF-A Induces Angiogenesis, Arteriogenesis, Lymphangiogenesis, and Vascular Malformations	227	(12)
J.A. Nagy
E. Vasile
D. Feng
C. Sundberg
L.F. Brown
E.J. Manseau
A.M. Dvorak
H.F. Dvorak
Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy	239	(10)
R.K. Jain
A Genetic Approach to Understanding Tumor Angiogenesis	249	(6)
R. Benezra
P. de Candia
H. Li
E. Romero
D. Lyden
S. Rafli
M. Ruzinova
Discovery of Type IV Collagen Non-collagenous Domains as Novel Integrin Ligands and Endogenous Inhibitors of Angiogenesis	255	(12)
R. Kalluri
Complementary and Coordinated Roles of the VEGFs and Angiopoietins during Normal and Pathologic Vascular Formation	267	(8)
N.W. Gale
G. Thurston
S. Davis
S.J. Wiegand
J. Holash
J.S. Rudge
G.D. Yancopoulos
Involvement of G Proteins in Vascular Permeability Factor/Vascular Endothelial Growth Factor Signaling	275	(10)
D. Mukhopadhyay
H. Zeng
Targeted Delivery of Mutant Raf Kinase to Neovessels Causes Tumor Regression	285	(8)
J.D. Hood
D.A. Cheresh
Combining Antiangiogenic Agents with Metronomic Chemotherapy Enhances Efficacy against Late-stage Pancreatic Islet Carcinomas in Mice	293	(8)
G. Bergers
D. Hanahan
Genetics and Genomics of the Cardiovascular System
Zebrafish: The Complete Cardiovascular Compendium	301	(8)
C.A. MacRae
M.C. Fishman
Consomic Rats for the Identification of Genes and Pathways Underlying Cardiovascular Disease	309	(8)
R.J. Roman
A.W. Cowley, Jr.
A. Greene
A.E. Kwitek
P.J. Tonellato
H.J. Jacob
A Mouse Model of Congenital Heart Disease: Cardiac Arrhythmias and Atrial Septal Defect Caused by Haploinsufficiency of the Cardiac Transcription Factor Csx/Nkx2.5	317	(10)
M. Tanaka
C.I. Berul
M. Ishii
P.Y. Jay
H. Wakimoto
P. Douglas
N. Yamasaki
T. Kawamoto
J. Gehrmann
C.T. Maguire
M. Schinke
C.E. Seidman
J.G. Seidman
Y. Kurachi
S. Izumo
Genetic Dissection of the DiGeorge Syndrome Phenotype	327	(6)
F. Vitelli
E.A. Lindsay
A. Baldini
A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with Autosomal Recessive Catecholamine-induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel	333	(6)
M. Eldar
E. Pras
H. Lahat
Regulation of the Heart
Calcium-dependent Gene Regulation in Myocyte Hypertrophy and Remodeling	339	(6)
R.S. Williams
P. Rosenberg
A Gradient of Myosin Regulatory Light-chain Phosphorylation across the Ventricular Wall Supports Cardiac Torsion	345	(8)
J.S. Davis
S. Hassanzadeh
S. Winitsky
H. Wen
A. Aletras
N.D. Epstein
Molecular and Functional Maturation of the Murine Cardiac Conduction System	353	(10)
S. Rentschler
G.E. Morley
G.I. Fishman
The Yin/Yang of Innate Stress Responses in the Heart	363	(8)
D.L. Mann
Regulatory Networks Controlling Mitochondrial Energy Production in the Developing, Hypertrophied, and Diabetic Heart	371	(12)
B.N. Finck
J.J. Lehman
P.M. Barger
D.P. Kelly
Heart Disease and Failure
Molecular Epidemiology of Hypertrophic Cardiomyopathy	383	(6)
H. Morita
S.R. DePalma
M. Arad
B. McDonough
S. Barr
C. Duffy
B.J. Maron
C.E. Seidman
J.G. Seidman
The Sarcoglycan Complex in Striated and Vascular Smooth Muscle	389	(10)
M.T. Wheeler
M.J. Allikian
A. Heydemann
E.M. McNally
The MLP Family of Cytoskeletal Z Disc Proteins and Dilated Cardiomyopathy: A Stress Pathway Model for Heart Failure Progression	399	(10)
M. Hoshijima
M. Pashmforoush
R. Knoll
K.R. Chien
From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy	409	(8)
A. Maass
J.P. Konhilas
B.L. Stauffer
L.A. Leinwand
Vascular Endothelium in Tissue Remodeling: Implications for Heart Failure	417	(12)
S.M. Dallabrida
M.A. Rupnick
Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure	429	(10)
B.G. Petrich
P. Liao
Y. Wang
G-Protein-coupled Receptor Function in Heart Failure	439	(6)
S.V. Naga Prasad
J. Nienaber
H.A. Rockman
Hypertension, Atherosclerosis, and Lipid Homeostasis
Salt and Blood Pressure: New Insight from Human Genetic Studies	445	(6)
R.P. Lifton
F.H. Wilson
K.A. Choate
D.S. Geller
Gene-targeting Studies of the Renin-Angiotensin System: Mechanisms of Hypertension and Cardiovascular Disease	451	(8)
S.B. Gurley
T.H. Le
T.M. Coffman
Modulation of Endothelial NO Production by High-density Lipoprotein	459	(12)
C. Mineo
P.W. Shaul
Plaque Angiogenesis: Its Functions and Regulation	471	(12)
K.S. Moulton
Extracellular Superoxide Dismutase, Uric Acid, and Atherosclerosis	483	(8)
H. U. Hink
T. Fukai
SREBPs: Transcriptional Mediators of Lipid Homeostasis	491	(8)
J.D. Horton
J.L. Goldstein
M.S. Brown
Genetic Defenses against Hypercholesterolemia	499	(8)
H.H. Hobbs
G.A. Graf
L. Yu
K.R. Wilund
J.C. Cohen
Repairing the Cardiovascular System
Insulin-like Growth Factor Isoforms in Skeletal Muscle Aging, Regeneration, and Disease	507	(12)
N. Winn
A. Paul
A. Musaro
N. Rosenthal
Cellular Therapies for Myocardial Infarct Repair	519	(8)
C.E. Murry
M.L. Whitney
M.A. Laflamme
H. Reinecke
L.J. Field
Gene Therapy for Cardiac Arrhythmias	527	(6)
E. Marban
H.B. Nuss
J.K. Donahue
Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling	533	(10)
X.H.T. Wehrens
A.R. Marks
Summary: The Coming of Age of Cardiovascular Science	543	(8)
C.E. Seidman
J.G. Seidman
Author Index	551	(2)
Subject Index	553