9780721666976

Cecil Essentials of Medicine

by ; ; ; ;
  • ISBN13:

    9780721666976

  • ISBN10:

    0721666973

  • Edition: 4th
  • Format: Paperback
  • Copyright: 1997-02-01
  • Publisher: Elsevier Science Health Science div
  • View Upgraded Edition

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Supplemental Materials

What is included with this book?

Summary

For almost 20 years, Cecil Essentials of Medicine has been a trusted and respected name in Internal Medicine.

The new 5 th Edition continues this legacy by laying the groundwork for effective diagnosis and treatment by presenting the core of internal medicine in an easy-to-read format.

Concise and complete, incorporates important advances in diagnosis and therapy.

Table of Contents

SECTION I CARDIOVASCULAR DISEASE 1(110)
Structure and Function of the Normal Heart and Blood Vessels
3(7)
Gross Anatomy
3(1)
Electrical Conduction System
4(1)
Microscopic Anatomy
5(1)
Fetal Circulation
6(1)
Myocardial Metabolism
6(1)
Circulatory Physiology
6(2)
Physiology of the Coronary Circulation
8(1)
Physiology of the Systemic Circulation
8(1)
Physiology of the Pulmonary Circulation
9(1)
Cardiovascular Response to Exercise
9(1)
Cardiovascular Physiology During Pregnancy
9(1)
Electrophysiology
9(1)
Evaluation of the Patient with Cardiovascular Disease
10(10)
History
10(3)
Arterial Pressure and Pulses
13(1)
Examination of the Neck Veins
14(1)
Precordial Examination
15(1)
Cardiac Auscultation
15(1)
Abnormal Heart Sounds
15(2)
Abnormal Murmurs
17(2)
Prosthetic Valve Sounds
19(1)
Special Tests and Procedures in the Patient with Cardiovascular Disease
20(13)
Cardiac Radiography
20(1)
Electrocardiography
20(2)
Abnormal ECG Patterns
22(5)
Long-Term Ambulatory ECG Recording
27(1)
Stress Testing
27(1)
Echocardiography
28(1)
Nuclear Cardiology
28(1)
Other Techniques
29(1)
Cardiac Catheterization
29(1)
Special Techniques
30(3)
Congestive Heart Failure
33(7)
Evaluation and Treatment of Patients with Heart Failure
34(2)
Diuretics
36(1)
Vasodilators
36(1)
Digitalis
37(1)
Sympathomimetic Amines
37(1)
Cardiovascular Assist Devices
37(1)
Acute Pulmonary Edema
38(1)
Diastolic Heart Failure
39(1)
Congenital Heart Disease
40(5)
Bicuspid Aortic Valve
40(1)
Coarctation of the Aorta
40(2)
Pulmonic Valve Stenosis
42(1)
Atrial Septal Defect
42(1)
Ventricular Septal Defect
42(1)
Patent Ductus Arteriosus
43(1)
Tetralogy of Fallot
43(1)
General Considerations in the Evaluation and Management of Adults with Congenital Heart Disease
44(1)
Acquired Valvular Heart Disease
45(8)
General Considerations
45(1)
Aortic Stenosis
45(1)
Aortic Regurgitation
46(2)
Mitral Stenosis
48(1)
Mitral Regurgitation
49(1)
Mitral Valve Prolapse
50(1)
Tricuspid Stenosis
50(1)
Tricuspid Regurgitation
50(1)
Pulmonic Stenosis and Regurgitation
51(1)
Multivalvular Disease
51(1)
Rheumatic Fever
51(1)
Prosthetic Valves
51(2)
Coronary Heart Disease
53(16)
Atherosclerosis
53(1)
Risk Factors
53(1)
Nonatherosclerotic Causes of Coronary Artery Obstruction
54(1)
Nonobstructive Causes of Ischemic Heart Disease
54(1)
Pathophysiology of Ischemic Heart Disease
54(1)
Angina Pectoris
55(2)
Medical Management of Angina
57(2)
Coronary Bypass Surgery and Coronary Angioplasty for Angina Pectoris
59(1)
Variant Angina
60(1)
Acute Myocardial Infarction
61(2)
Treatment of Acute Myocardial Infarction
63(1)
Thrombolytic Therapy and Primary Coronary Angioplasty for Acute Myocardial Infarction
63(2)
Other Measures
65(1)
Non-Q Wave Myocardial Infarction
65(1)
Complications of Myocardial Infarction and Their Management
66(3)
Arrhythmias
69(25)
Mechanisms of Arrhthymogenesis
69(2)
Approach to the Patient with Suspected or Confirmed Arrhythmias
71(1)
Management of Cardiac Arrhythmias
72(8)
Specific Arrhythmias
80(12)
Principles of Cardiopulmonary Resuscitation
92(2)
Myocardial and Pericardial Disease
94(6)
Myocardial Disease
94(2)
Pericardial Disease
96(4)
Cardiac Tumors and Trauma
100(2)
Cardiac Tumors
100(1)
Nonpenetrating Trauma
100(1)
Penetrating Trauma
101(1)
Aortic and Peripheral Vascular Disease
102(5)
Aortic Aneurysms
102(1)
Aortic Dissection
102(1)
Aortic Arteritis
102(1)
Miscellaneous Aortic Disease
103(1)
Peripheral Vascular Disease
103(2)
Peripheral Aneurysms and Fistulas
105(1)
Arterial Trauma
105(1)
Peripheral Venous Disease
105(1)
Deep Vein Thrombosis
106(1)
Other Cardiac Topics
107(4)
Transplantation
107(1)
Surgery
107(1)
Pregnancy
108(3)
Section II RESPIRATORY DISEASE 111(54)
Approach to the Patient with Respiratory Disease
113(4)
Common Presenting Complaints
113(1)
Physical Examination
114(3)
Anatomic and Physiologic Considerations
117(9)
The Airway
117(1)
Ventilation
117(4)
The Blood Vessels
121(2)
Pulmonary Gas Exchange
123(1)
Nonpulmonary Factors
124(1)
Growth and Aging of the Normal Lung
124(1)
Nonrespiratory Functions of the Lung
125(1)
Diagnostic Techniques and their Indications
126(5)
Imaging Procedures
126(1)
Pulmonary Function Evaluation
126(5)
Obstructive Lung Disease
131(9)
Pathophysiology of Airway Obstruction
131(1)
Asthma
132(1)
Chronic Obstructive Pulmonary Disease (COPD)
133(1)
Emphysema
134(1)
Small Airway Disease
134(1)
Chronic Bronchitis
134(1)
Bronchiectasis
134(1)
Cystic Fibrosis
135(1)
Treatment
136(1)
Pharmacologic Therapy
136(1)
Oxygen
137(1)
Antibiotics and Vaccines
137(1)
Smoking Cessation
138(1)
Physical Therapy and Rehabilitation
138(1)
Volume Reduction Surgery and Lung Transplantation
138(2)
Diffuse Infiltrative Diseases of the Lung
140(6)
Clinical Manifestations
140(1)
Specific Entities
140(5)
Treatment
145(1)
Pulmonary Vascular Disease
146(4)
Physiologic Effects of Pulmonary Hypertension
146(1)
Causes of Pulmonary Hypertension
146(1)
Pulmonary Embolism
146(3)
Primary Pulmonary Hypertension
149(1)
Disorders of the Pleural Space, Mediastinum, and Chest Wall
150(5)
Pleural Disease
150(2)
Mediastinal Disease
152(1)
Chest Wall Disease
153(2)
Neoplastic Diseases of the Lung
155(4)
Lung Tumor Biology
155(1)
Pathology
155(1)
Clinical Presentation
156(1)
Diagnosis and Evaluation
156(1)
Solitary Pulmonary Nodule
157(1)
Treatment and Prognosis
158(1)
Control of Breathing in Disease States
159(3)
Sleep Apnea Syndrome
159(2)
Breathing Pattern Abnormalities Associated with Neurologic Disease
161(1)
Neuromuscular Disease
161(1)
Inhalational and Environmental Injury
162(3)
Drowning and Near-Drowning
162(1)
Diseases of Altitude
162(1)
Smoke Inhalation Injury
163(1)
Noxious Gases and Fumes
163(2)
Section III PULMONARY CRITICAL CARE 165(8)
Essentials of Pulmonary Critical Care Medicine
167(6)
Shock
167(1)
Acute Respiratory Failure
168(1)
Oxygen Therapy and Mechanical Ventilation
168(2)
Multiple Organ Dysfunction Syndrome, Systemic Inflammatory Response Syndrome, Sepsis, and Adult Respiratory Distress Syndrome
170(3)
Section IV RENAL DISEASE 173(80)
Elements of Renal Structure and Function
175(8)
Elements of Renal Structure
175(2)
Elements of Renal Physiology
177(4)
Renal Homeostatic Functions
181(2)
Approach to the Patient with Renal Disease
183(5)
Clinical Assessment of the Patient with Renal Disease
183(2)
The Major Renal Syndromes
185(1)
Anatomic Imaging of the Urinary Tract
186(2)
Fluid and Electrolyte Disorders
188(17)
Volume Disorders
188(3)
Osmolality Disorders
191(1)
Hyponatremia
192(2)
Hypernatremic Disorders
194(1)
Disturbances in Potassium Balance
195(3)
Disturbances in Acid-Base Balance
198(7)
Glomerular Diseases
205(12)
The Glomerulus
205(1)
Mechanisms of Glomerular Injury
205(1)
Clinical Manifestations of Glomerular Disease
205(1)
Approach to the Patient with Glomerular Disease
206(1)
Acute Nephritic Syndrome
207(1)
Rapidly Progressive Glomerulonephritis (RPGN)
208(1)
Nephrotic Syndrome
209(5)
Asymptomatic Urinary Abnormalities
214(2)
Chronic Glomerulonephritis (CGN)
216(1)
Major Nonglomerular Disorders
217(10)
Tubulointerstitial Nephropathy
217(3)
Cystic Diseases of the Kidney
220(1)
Urinary Tract Obstruction
221(1)
Nephrolithiasis
222(2)
Renal Tumors
224(3)
Hypertension and Vascular Disorders of the Kidney
227(8)
Arterial Hypertension
227(4)
Vascular Disorders of the Kidney
231(4)
Acute Renal Failure
235(8)
Definition and Etiology
235(1)
Differential Diagnosis and Diagnostic Evaluation of the Patient
235(3)
Clinical Presentation, Complications, and Management of Acute Tubular Necrosis
238(2)
Specific Causes of Acute Renal Failure
240(3)
Chronic Renal Failure
243(10)
Adaptation to Nephron Loss
243(2)
Clinical Manifestations of Renal Failure
245(3)
Kidney Transplantation
248(5)
Section V GASTROINTESTINAL DISEASE 253(66)
The Common Clinical Manifestations of Gastrointestinal Disease
255(21)
Abdominal Pain
255(3)
Gastrointestinal Hemorrhage
258(4)
Malabsorption
262(7)
Diarrhea
269(7)
Radiographic and Endoscopic Procedures in Gastroenterology
276(6)
Radiographic Procedures
276(3)
Endoscopic Procedures
279(3)
Diseases of the Esophagus
282(6)
Normal Esophageal Physiology
282(1)
Clinical Symptoms of Esophageal Disease
282(1)
Gastroesophageal Reflux Disease
283(2)
Motility Disorders of the Oropharynx and Esophagus
285(1)
Other Esophageal Disorders
286(2)
Diseases of the Stomach and Duodenum
288(11)
Normal Gastric Physiology
288(2)
Gastritis
290(1)
Peptic Ulcer Disease of the Stomach and Duodenum
291(5)
The Zollinger-Ellison Syndrome
296(1)
Abnormalities of Gastric Emptying
297(2)
Inflammatory Bowel Disease
299(6)
Definition
299(1)
Etiology and Pathogenesis
299(1)
Pathology
299(1)
Clinical Manifestations
300(1)
Diagnosis
301(1)
Treatment and Prognosis
301(2)
Complications
303(1)
Ischemic Colitis
303(1)
Diverticulitis
304(1)
Neoplasms of the Gastrointestinal Tract
305(7)
Carcinoma of the Esophagus
305(1)
Carcinoma of the Stomach
306(1)
Carcinoma of the Colon
307(2)
Polyps of the Gastrointestinal Tract
309(1)
The Familial Polyposis Syndromes
310(2)
The Pancreas
312(7)
Normal Structure and Function
312(1)
Acute Pancreatitis
313(2)
Chronic Pancreatitis
315(2)
Carcinoma of the Pancreas
317(2)
Section VI DISEASES OF THE LIVER AND BILIARY SYSTEM 319(34)
Laboratory Tests in Liver Disease
321(2)
Clinical Approach to Liver Disease
321(1)
Laboratory Tests of Liver Function and Disease
321(1)
Tests of Hepatic Function
321(1)
Screening Tests of Hepatobiliary Disease
321(2)
Liver Biopsy
323(1)
Jaundice
323(6)
Definition
324(1)
Bilirubin Metabolism
324(1)
Laboratory Tests for Bilirubin
324(1)
Clinical Classification of Jaundice
324(3)
Approach to the Diagnosis of Jaundice
327(2)
Acute and Chronic Hepatitis
329(8)
Definition
329(1)
Acute Hepatitis
329(6)
Chronic Hepatitis
335(2)
Fulminant Hepatic Failure
337(2)
Diagnosis
337(1)
Treatment
337(1)
Hepatic Transplantation
338(1)
Prognosis
338(1)
Cirrhosis of the Liver and its Complications
339(6)
Definition
339(1)
Clinical and Laboratory Features
339(1)
Specific Causes of Cirrhosis
339(1)
Major Complications of Cirrhosis
340(4)
Hepatic Transplantation
344(1)
Neoplastic, Infiltrative, and Vascular Diseases of the Liver
345(3)
Hepatic Neoplasms
345(1)
Liver Abscess
346(1)
Granulomatous Liver Disease
346(1)
Vascular Disease of the Liver
347(1)
Disorders of the Gallbladder and Biliary Tract
348(5)
Normal Biliary Physiology
348(1)
Pathophysiology of Gallstone Formation (Cholelithiasis)
348(1)
Clinical Manifestations of Gallstones
349(4)
Section VII HEMATOLOGIC DISEASE 353(70)
The Blood and Bone Marrow
355(3)
The Blood
355(1)
The Bone Marrow
355(3)
Disorders of the Hematopoietic Stem Cell
358(9)
The Myeloaplastic Disorders
358(1)
The Myelodysplastic Disorders
359(3)
Myeloproliferative Disorders
362(2)
Acute Leukemia
364(3)
Disorders of Lymphocytes
367(10)
Ontology of Lymphocytes
367(1)
Localization of Lymphocytes
368(1)
Disorders of the Lymphatic System
369(5)
Plasma Cell Disorders
374(3)
Disorders of Granulocytes and Monocytes
377(4)
Neutrophil Structure and Function
377(1)
Monocyte Structure and Function
378(1)
Neutropenia
378(1)
Neutrophil Leukocytosis
379(1)
Eosinophilia
380(1)
Disorders of Red Cells
381(17)
Shape and Structure of Red Cells
381(1)
Birth and Death of Red Cells
381(1)
Anemia
381(17)
Transfusion and Bone Marrow Transplantation
398(5)
Transfusion
398(3)
Allogeneic Bone Marrow Transplantation (BMT)
401(2)
Platelets and Primary Hemostasis
403(8)
Primary Hemostasis
403(1)
Quantitative Platelet Disorders
404(3)
Thrombocytosis
407(1)
Qualitative Platelet Disorders
408(1)
Vascular Purpuras
408(1)
Plasma Protein Disorders Affecting Primary Hemostasis
409(2)
Blood Coagulation and its Disorders
411(12)
Secondary Hemostasis and Clot Stabilization
411(5)
Factor Inhibitors
416(1)
Natural Anticoagulants and the Fibrinolytic Pathway
416(1)
Primary Hypercoagulable States
417(2)
Secondary Hypercoagulable States
419(1)
Therapy of Thromboembolic Disease
419(4)
Section VIII ONCOLOGIC DISEASE 423(18)
General Considerations in Oncology
425(7)
Etiology
425(3)
Screening for Early Cancer Detection
428(1)
Systemic Effects of Cancer
429(3)
Principles of Cancer Therapy
432(6)
Forming a Treatment Plan
432(1)
Principles of Oncologic Surgery
432(1)
Principles of Radiation Therapy
433(1)
Principles of Chemotherapy
434(2)
Hormonal Therapy
436(1)
Biologic Response Modifiers
436(2)
Oncologic Emergencies
438(3)
Hypercalcemia
438(1)
Spinal Cord Compression
438(2)
Increased Intracranial Pressure
440(1)
Superior Vena Cava Syndrome
440(1)
Section IX METABOLIC DISEASE 441(34)
Introduction to Metabolic Disease
443(2)
Eating Disorders
445(6)
Obesity
445(2)
Anorexia Nervosa and Bulimia Nervosa
447(4)
Principles of Nutritional Support in Adult Patients
451(3)
Nutritional Assessment
451(1)
Route of Nutritional Support
451(1)
Water
451(1)
Calories and Protein
451(2)
Vitamins and Minerals
453(1)
Home Nutritional Support
453(1)
Hyperuricemia and Gout
454(4)
Prevalence
454(1)
Mechanisms of Hyperuricemia
454(1)
Pathogenesis of Gout Arthritis
454(1)
Pathogenesis of Renal Disease
454(1)
Pathogenesis of Tophi
455(1)
Clinical Features
455(1)
Treatment
456(2)
Disorders of Lipid Metabolism
458(6)
Plasma Lipoprotein Physiology
458(1)
Evaluation of Serum Lipoprotein Concentrations
458(1)
Elevated Chylomicrons, VLDL, and IDL
459(1)
Treatment of Hypertriglyceridemia
460(2)
Elevated LDL
462(1)
Treatment of Hypercholesterolemia
462(1)
Lipids and Vascular Disease
463(1)
Disorders of Metals and Metalloproteins
464(6)
Wilson's Disease
464(1)
Hemochromatosis
465(1)
The Porphyrias
466(4)
Disorders of Amino Acid Metabolism
470(3)
Homocystinemia
470(1)
Cystinuria
470(3)
Inherited Disorders of Connective Tissue
473(2)
Osteogenesis Imperfecta
473(1)
Ehlers-Danlos Syndrome
473(1)
Marfan's Syndrome
473(1)
Mucopolysaccharidoses
474(1)
Section X ENDOCRINE DISEASE 475(78)
Hypothalamic-Pituitary Axis
477(10)
Anatomy
477(1)
Anterior Pituitary Hormone Physiology and Testing
477(3)
Neuroradiologic Evaluation of the Pituitary
480(1)
Pituitary and Hypothalamic Disorders
481(1)
Hypothalamic Dysfunction
481(1)
Hypopituitarism
481(1)
Empty Sella Syndrome
482(1)
Pituitary Tumors
483(2)
The Posterior Pituitary Gland
485(1)
Di
485(1)
Siadh
486(1)
The Thyroid Gland
487(10)
Thyroid Hormone Physiology
487(1)
Thyroid Evaluation
488(1)
Hyperthyroidism
489(1)
Graves' Disease
490(1)
Toxic Adenoma
491(1)
Toxic Multinodular Goiter
491(1)
Thyroiditis
491(1)
Thyrotoxicosis Factitia
492(1)
Rare Causes of Thyrotoxicosis
492(1)
Hypothyroidism
492(2)
Goiter
494(1)
Solitary Thyroid Nodules
494(1)
Thyroid Carcinoma
495(2)
Adrenal Gland
497(12)
Physiology
497(1)
Adrenal Insufficiency
498(3)
Hyporeninemic Hypoaldosteronism
501(1)
Congenital Adrenal Hyperplasia
501(1)
Syndromes of Adrenocorticoid Hyperfunction
502(7)
Female Reproductive Endocrinology
509(10)
Normal Sexual Development
509(1)
Precocious Puberty
509(2)
Amenorrhea
511(3)
Hirsutism
514(3)
Infertility
517(1)
Dysmenorrhea
517(1)
Premenstrual Syndrome (PMS)
517(1)
Menopause
518(1)
Cancer of the Breast, Cervix, Uterus, and Ovary
519(6)
Cancer of the Breast
519(1)
Carcinoma of the Cervix
520(1)
Cancer of the Uterus
521(2)
Ovarian Carcinoma
523(2)
Male Reproductive Endocrinology
525(8)
Hypogonadism
525(4)
Primary Gonadal Abnormalities
529(1)
Defects in Androgen Action
529(1)
Impotence
529(1)
Gynecomastia
529(1)
Testicular Tumors
530(1)
Benign Prostatic Hyperplasia
531(1)
Carcinoma of the Prostate
531(2)
Diabetes Mellitus
533(13)
Basic Classification
533(2)
Diagnosis
535(1)
Pathogenesis
535(1)
Treatment of Diabetes
536(3)
Complications
539(7)
Hypoglycemia
546(7)
Definition of a Low Blood Glucose Level
546(1)
Normal Physiology
546(1)
Causes of Hypoglycemia
547(3)
Diagnostic Work-Up for Hypoglycemia
550(1)
Treatment
550(3)
Section XI DISEASES OF BONE AND BONE MINERAL METABOLISM 553(34)
Normal Physiology of Bone and Bone Minerals
555(9)
Bone Structure and Metabolism
555(1)
Calcium Metabolism
555(2)
Phosphorus Metabolism
557(2)
Magnesium Metabolism
559(2)
Vitamin D
561(1)
Calcitonin
562(2)
The Parathyroid Glands, Hypercalcemia, and Hypocalcemia
564(9)
Normal Physiology
564(1)
Hypercalcemia
564(5)
Hypocalcemia
569(4)
Osteomalacia and Rickets
573(4)
Pathogenesis
573(1)
Specific Causes
573(2)
Clinical Manifestations
575(1)
Laboratory and Radiographic Features
575(1)
Diagnosis
576(1)
Treatment
576(1)
Osteoporosis
577(7)
General Considerations
577(1)
Etiology and Pathogenesis
577(2)
Clinical Manifestations
579(1)
Radiographic Findings
579(1)
Diagnosis
579(2)
Treatment
581(1)
Glucocorticoid-Induced Bone Loss
582(2)
Paget's Disease of Bone
584(3)
Incidence and Prevalence
584(1)
Etiology
584(1)
Pathology and Pathophysiology
584(1)
Clinical Picture
584(1)
Associated Conditions
585(1)
Laboratory Assessment
585(1)
Treatment
585(2)
Sectiion XII MUSCULOSKELETAL AND CONNECTIVE TISSUE DISEASE 587(50)
Approach to the Patient with Musculoskeletal Disease
589(5)
Laboratory Tests
589(3)
Radiologic Evaluation
592(2)
Rheumatoid Arthritis
594(4)
Pathogenesis
594(1)
Clinical Manifestations
594(2)
Treatment
596(2)
Systemic Lupus Erythematosus
598(5)
Etiology and Pathogenesis
598(1)
Clinical Features
599(2)
Laboratory Evaluation
601(1)
Treatment
601(2)
Sjogren's Syndrome
603(2)
Clinical Features
603(1)
Diagnosis
603(1)
Treatment
604(1)
Idiopathic Inflammatory Myopathies
605(3)
Clinical Course
605(1)
Diagnostic and Laboratory Findings
606(1)
Treatment
606(2)
Scleroderma (Systemic Sclerosis)
608(4)
Localized Scleroderma
608(1)
Limited Systemic Sclerosis (CREST Variant)
608(1)
Diffuse Systemic Sclerosis
608(1)
Scleroderma Sine Scleroderma
608(1)
Clinical Features
608(2)
Differential Diagnosis
610(1)
Treatment
611(1)
Mixed Connective Tissue Disease, Overlap Syndrome, and Antiphospholipid Antibody Syndrome
612(2)
Mixed Connective Tissue Disease and Overlap Syndrome
612(1)
Antiphospholipid Antibody Syndrome
612(2)
Vasculitides
614(6)
Classification
614(1)
Immunopathogenesis
614(1)
Hypersensitivity Angiitis
614(1)
Polyarteritis Nodosa
615(1)
Allergic Vasculitis of Churg and Strauss
616(1)
Wegener's Granulomatosis
616(1)
Polymyalgia Rheumatica and Giant Cell Arteritis
617(3)
The Spondyloarthropathies
620(4)
Ankylosing Spondylitis
620(1)
Reiter's Syndrome
621(2)
Psoriatic Arthritis
623(1)
Arthritis Associated with Inflammatory Bowel Disease
623(1)
Osteoarthritis
624(3)
Classification
624(1)
Etiology and Pathogenesis
624(1)
Clinical Features
624(2)
Differential Diagnosis
626(1)
Treatment
626(1)
The Crystal-Induced Arthropathies
627(2)
Chondrocalcinosis and Associated Disorders
627(2)
Miscellaneous Forms of Arthritis
629(5)
Musculoskeletal Syndromes Associated with Malignancy
629(1)
Arthropathies Associated with Endocrine Diseases
630(1)
Additional Miscellaneous Disorders
631(3)
Nonarticular Rheumatism
634(3)
Painful Shoulder
634(1)
Bursitis
634(1)
Carpal Tunnel Syndrome
634(1)
Fibromyalgia Syndrome
635(2)
Section XIII INFECTIOUS DISEASE 637(144)
Organisms that Infect Humans
639(6)
Viruses
639(1)
Chlamydiae
639(1)
Rickettsiae
639(1)
Mycoplasmas
640(1)
Bacteria
640(2)
Fungi
642(1)
Protozoans
643(1)
Helminths
643(2)
Host Defenses Against Infection
645(8)
Local Barriers to Infection
645(1)
Components of the Immune System
646(3)
Nonspecific Effector Mechanisms
649(1)
Resistance to Extracellur Bacteria
650(1)
Resistance to Obligate Intracellular Parasites: Viruses
651(1)
Resistance to Faculative Intracellular Parasites: Mycobacterium Tuberculosis
652(1)
Laboratory Diagnosis of Infectious Diseases
653(4)
Diagnosis by Direct Visualization of the Organism
653(1)
Diagnosis by Detection of Microbial Antigens
654(1)
Diagnosis by Examination of Host Immune or Inflammatory Responses
655(1)
Diagnosis by Detection of Microbial Nucleotide Sequences
655(1)
Diagnosis by Isolation of the Organism in Culture
655(2)
Antimicrobial Therapy
657(6)
The Pathogen
657(1)
Site of Infection
657(2)
Characteristics of the Antimicrobial
659(1)
Route of Administration
660(1)
Monitoring of Antimicrobial Therapy
660(1)
Antiviral Agents
660(1)
Antifungal Agents
661(2)
Fever and Febrile Syndromes
663(14)
Regulation of Body Temperature
663(1)
Fever and Hyperthermia
663(2)
Acute Febrile Syndromes
665(8)
Fuo
673(4)
Bacteremia
677(5)
Epidemiology
677(1)
Pathogenesis
678(1)
Clinical Manifestations
679(1)
Diagnosis
680(1)
Therapy
680(2)
Infections of the Nervous System
682(11)
Meningitis
683(5)
Encephalitis
688(2)
Spectrum of Tuberculous, Fungal, and Parasitic Infections
690(3)
Infections of the Head and Neck
693(6)
Infections of the Ear
693(1)
Infections of the Nose and Sinuses
693(1)
Infections of the Mouth and Pharynx
694(5)
Infections of the Lower Respiratory Tract
699(9)
Pathogenesis of Pneumonia
699(1)
Epidemiology
699(1)
Diagnostic Approach to the Patient
700(1)
Radiographic Patterns in Patients with Pneumonia
700(1)
Other Laboratory Findings
701(1)
Diagnosis and Management of the Patient with Pneumonia
701(1)
Specific Pathogenic Organisms
702(3)
Treatment and Outcome
705(2)
Prevention
707(1)
Infections of the Heart and Vessels
708(7)
Infective Endocarditis (IE)
708(4)
Prosthetic Valve Endocarditis (PVE)
712(1)
Prophylaxis of Infective Endocarditis
712(1)
Bacterial Endarteritis and Suppurative Phlebitis
713(2)
Skin and Soft Tissue Infections
715(5)
Superficial Infections of the Skin
715(4)
Deeper Infections of the Skin and Soft Tissue
719(1)
Intra-Abdominal Abscess and Peritonitis
720(4)
Intra-Abdominal Abscess
720(1)
Abscesses of Solid Organs
720(2)
Extravisceral Abscesses
722(1)
Peritonitis
722(2)
Acute Infectious Diarrhea
724(6)
Pathogenesis and Pathophysiology: General Concepts
724(1)
Types of Microbial Diarrheal Diseases
724(2)
General Epidemiologic Considerations
726(1)
Diagnosis
727(1)
Management: General Principles of Electrolyte Repletion Therapy
727(3)
Infections Involving Bones and Joints
730(4)
Arthritis
730(2)
Septic Bursitis
732(1)
Osteomyelitis
732(2)
Infections of the Urinary Tract
734(3)
Urethritis
734(1)
Cystitis and Pyelonephritis
734(2)
Prostatitis
736(1)
Nosocomial Infections
737(4)
Approach to the Hospitalized Patient with Suspected Nosocomial Infection
737(1)
Nosocomial Pneumonia
738(1)
Intravascular Catheter-Related Infections
739(1)
Pressure Sores
739(1)
Nosocomial Urinary Tract Infection
739(2)
Sexually Transmitted Diseases
741(8)
Genital Sores
741(4)
Urethritis, Cervicitis, and Pelvic Inflammatory Disease (PID)
745(4)
HIV Infection and the Acquired Immunodeficiency Syndrome
749(20)
Epidemiology
749(2)
Pathophysiology
751(2)
Diagnosis and Testing for HIV Infection
753(2)
Sequential Clinical Manifestations of HIV-1 Infection
755(1)
Management of HIV Infection
756(3)
Management of Specific Clinical Manifestations of Immunodeficiency: A Problem-Oriented Approach
759(1)
Mucocutaneous Diseases
759(2)
Nervous System Diseases
761(2)
Pulmonary Diseases
763(1)
Gastrointestinal Diseases
764(2)
Other Complications of HIV Infection
766(1)
Prevention of HIV Infection
767(2)
Infections in the Immunocompromised Host
769(4)
Disorders of Cell-Mediated Immunity
769(1)
Disorders of Humoral Immunity
769(1)
Impaired Neutrophil Function
770(1)
Neutropenia
770(1)
Diagnostic Problems in the Compromised Host
771(1)
Prevention and Treatment of Infections in the Neutropenic Patient
772(1)
Infectious Diseases of Travelers; Protozoal and Helminthic Infections
773(8)
Preparation of Travelers
773(2)
The Returning Traveler
775(1)
Protozoal and Helminthic Infections
776(5)
Section XIV NEUROLOGIC DISEASE 781(148)
Neurologic Evaluation of the Patient
783(6)
The Neurologic History
783(1)
The Neurologic Examination
784(1)
Diagnostic Tests: Scope and Limitations
785(4)
Disorders of Consciousness and Higher Brain Function
789(14)
Sleep and Its Disorders
789(1)
Pathologic Alterations of Consciousness
790(6)
Focal Disturbances of Higher Brain Function
796(3)
Dementia
799(4)
Disorders of Mood and Behavior
803(12)
Psychiatric Disorders
803(4)
Drug and Alcohol Abuse
807(8)
Disorders of Autonomic Function
815(3)
Hypothalamus (HT)
815(2)
Central and Peripheral Autonomic Insufficiencies
817(1)
Disorders of Sensory Function
818(21)
Pain and Painful Syndromes
818(8)
The Special Senses
826(13)
Disorders of the Motor System
839(19)
Mechanisms of Normal and Abnormal Motor Function
839(6)
Movement Disorders
845(4)
The Major Cerebellar Ataxias
849(3)
Mechanical Lesions of the Spine and Spinal Cord
852(6)
Cerebrovascular Disease
858(16)
Anatomy and Pathophysiology of the Cerebral Circulation
858(1)
Epidemiology and Risk Factors
859(1)
Ischemic Stroke
860(8)
Spontaneous Parenchymal Cerebral Hemorrhage
868(3)
Intracranial Aneurysms
871(2)
Arteriovenous Malformations (AVMs)
873(1)
Trauma to the Head and Spine
874(5)
Head/Brain Injury
874(3)
Spinal Cord Injury
877(2)
Epilepsy
879(9)
Incidence and General Etiology
879(1)
Pathophysiology
879(1)
Clinical Seizure Patterns
879(5)
Management
884(4)
Intracranial Neoplasms, CNS Complications of Cancer, and States of Altered Intracranial Pressure
888(10)
Intracranial Neoplasms
888(5)
Spinal Neoplasms
893(1)
Paraneoplastic Syndromes
893(2)
Non-Neoplastic Alterations of Intracranial Pressure
895(3)
Infectious and Inflammatory Disorders of the Nervous System
898(9)
Bacterial Infections of the Brain
898(4)
Slow Virus Infections of the Nervous System
902(1)
Demyelinating and Other CNS Inflammatory Disorders of Probable Immune Cause
903(4)
Motor Nerve, Nerve Root, Peripheral Nerve, and Neurocutaneous Disorders
907(14)
Peripheral Nerve Disorders
907(3)
Mono- and Polyneuropathies Affecting Somatic Cranial Nerve Functions
910(3)
Neurocutaneous Syndromes
913(1)
The Motor Neuron Dieseases
913(2)
Focal Radiculopathy and Neuropathy
915(4)
Polyneuropathy
919(2)
Disorders of Myoneural Junction and Skeletal Muscle
921(8)
Disorders of Myoneural Junction
921(2)
Disorders of Skeletal Muscle
923(6)
Section XV THE AGING PATIENT 929(10)
The Biology of Aging
931(8)
The Demographics of Aging and Implications for Health Care
931(2)
Assessment of the Older Patient
933(2)
Common and Often Inadequately Assessed Medical Problems of the Elderly
935(4)
Section XVI SUBSTANCE ABUSE 939(12)
Alcohol and Substance Abuse
941(10)
Screening
941(1)
Tobacco and Alcohol Abuse
941(4)
Prescription Drug Abuse
945(2)
Illicit Drug Abuse
947(4)
Appendix: Commonly Measured Laboratory Values 951(4)
Index 955

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