9780808922964

Cecil Essentials Of Medicine

by Unknown
  • ISBN13:

    9780808922964

  • ISBN10:

    0808922963

  • Edition: 6th
  • Format: Paperback
  • Copyright: 2004-06-01
  • Publisher: Elsevier Science Health Science div
  • Purchase Benefits
  • Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • Get Rewarded for Ordering Your Textbooks! Enroll Now
List Price: $44.00

Table of Contents

SECTION I Introduction to Molecular Medicine
1(14)
The Molecular Basis of Human Disease
3(12)
Joseph Loscalzo
Deoxyribonucleic Acid and the Genetic Code
3(3)
Regulation of Gene Expression
6(1)
Genetic Variation, Population Diversity, and Genetic Polymorphisms
7(1)
Genes and Human Disease
8(1)
Gene Mapping
9(1)
Identifying Mutant Genes
10(1)
Molecular Diagnostics
11(1)
Genetic Therapies
12(1)
Other Molecular Therapeutic Approaches
13(2)
SECTION II Decision Making in Medical Practice
15(6)
Evidence-Based Medicine, Quality of Life, and the Cost of Medicine
17(4)
Susan S. Beland
Critical Appraisal of the Literature
17(1)
Testing in Medical Practice
18(1)
Evaluating Evidence about Treatment
19(1)
The Internet in Clinical Practice
19(1)
Including the Patient in the Decision Process
20(1)
SECTION III Cardiovascular Disease
21(154)
Structure and Function of the Normal Heart and Blood Vessels
23(10)
Eric H. Awtry
Joseph Loscalzo
Microscopic Anatomy
23(1)
Gross Anatomy
23(1)
The Circulatory Pathway
24(1)
The Conduction System
25(1)
Neural Innervation
26(1)
Physiology of Contraction
26(1)
Circulatory Physiology and the Cardiac Cycle
27(3)
Cardiovascular Response to Exercise
30(3)
Evaluation of the Patient with Cardiovascular Disease
33(14)
Eric H. Awtry
Joseph Loscalzo
History
33(4)
Physical Examination
37(2)
Auscultation
39(8)
Diagnostic Tests and Procedures in the Patient with Cardiovascular Disease
47(16)
Lisa A. Mendes
Joseph Loscalzo
Chest Radiography
47(1)
Electrocardiography
47(6)
Stress Testing
53(2)
Echocardiography
55(1)
Nuclear Cardiology
55(2)
Cardiac Catheterization
57(2)
Other Diagnostic Procedures
59(1)
Noninvasive Vascular Testing
60(3)
Heart Failure and Cardiomyopathy
63(8)
Lisa A. Mendes
Joseph Loscalzo
Forms of Heart Failure
63(1)
Adaptive Mechanisms in Heart Failure
63(2)
Evaluation of Patients with Heart Failure
65(1)
Treatment
65(2)
Refractory Heart Failure
67(1)
Cardiovascular Assist Devices
68(1)
Acute Pulmonary Edema
68(1)
Diastolic Dysfunction
68(3)
Congenital Heart Disease
71(6)
Lisa A. Mendes
Joseph Loscalzo
General Considerations
71(1)
Fetal and Transitional Circulations
71(1)
Congenital Aortic Stenosis
71(1)
Coarctation of the Aorta
72(1)
Pulmonic Valve Stenosis
73(1)
Tetralogy of Fallot
73(1)
Atrial Septal Defect
74(1)
Ventricular Septal Defect
75(1)
Patent Ductus Arteriosus
75(1)
Other Congenital Abnormalities
76(1)
Acquired Valvular Heart Disease
77(10)
Lisa A. Mendes
Joseph Loscalzo
Aortic Stenosis
77(1)
Aortic Regurgitation
78(2)
Mitral Stenosis
80(1)
Mitral Regurgitation
81(1)
Mitral Valve Prolapse
82(1)
Tricuspid Stenosis
83(1)
Tricuspid Regurgitation
83(1)
Pulmonic Stenosis and Regurgitation
83(1)
Multivalvular Disease
84(1)
Rheumatic Heart Disease
84(1)
Prosthetic Heart Valves
84(1)
Endocarditis Prophylaxis
85(2)
Coronary Heart Disease
87(22)
Eric H. Awtry
Joseph Loscalzo
Epidemiology
87(1)
Pathophysiology of Atherosclerosis
87(1)
Risk Factors
88(1)
Nonatherosclerotic Causes of Cardiac Ischemia
89(1)
Pathophysiology and Consequences of Myocardial Ischemia
90(1)
Angina Pectoris
90(8)
Acute Coronary Syndromes
98(11)
Cardiac Arrhythmias
109(28)
Eric H. Awtry
Joseph Loscalzo
Mechanisms of Arrhythmogenesis
109(2)
Approach to the Patient with Suspected Arrhythmias
111(2)
Management of Cardiac Arrhythmias
113(7)
Specific Arrhythmias
120(9)
Heart Block
129(2)
Clinical Syndromes
131(3)
Principles of Cardiopulmonary Resuscitation
134(3)
Myocardial and Pericardial Disease
137(10)
Lisa A. Mendes
Joseph Loscalzo
Myocarditis
137(1)
Cardiomyopathy
137(4)
Amyloidosis
141(1)
Pericardial Disease
142(5)
Other Cardiac Topics
147(8)
Lisa A. Mendes
Joseph Loscalzo
Cardiac Tumors
147(1)
Traumatic Heart Disease
147(2)
Cardiac Surgery
149(1)
Noncardiac Surgery in the Cardiac Patient
150(2)
Cardiac Disease in Pregnancy
152(3)
Vascular Diseases and Hypertension
155(20)
Eric H. Awtry
Joseph Loscalzo
Systemic Vascular Disease
155(7)
Venous Thromboembolic Disease
162(3)
Pulmonary Vascular Disease
165(2)
Hypertension
167(8)
SECTION IV Pulmonary and Critical Care Medicine
175(52)
Approach to the Patient with Respiratory Disease
177(4)
Bonnie S. Slovis
Kenneth L. Brigham
Common Presenting Complaints
177(1)
Physical Examination
178(3)
Anatomic and Physiologic Considerations
181(8)
Bonnie S. Slovis
Kenneth L. Brigham
Anatomy
181(1)
Physiology
181(4)
Abnormalities of Pulmonary Gas Exchange
185(4)
Diagnostic Techniques and Their Indications
189(4)
Bonnie S. Slovis
Kenneth L. Brigham
Imaging Procedures
189(1)
Evaluation of Lung Function
189(4)
Obstructive Lung Disease
193(8)
Bonnie S. Slovis
Kenneth L. Brigham
Pathophysiology of Air Flow Obstruction
193(1)
Asthma
194(1)
Chronic Obstructive Pulmonary Disease
195(1)
Bronchiectasis
196(1)
Cystic Fibrosis
197(1)
Treatment
197(4)
Interstitial and Infiltrative Lung Disease
201(8)
Bonnie S. Slovis
Kenneth L. Brigham
Pathophysiology and Clinical Manifestations
201(8)
Disorders of the Pleural Space, Mediastinum, and Chest Wall
209(4)
Bonnie S. Slovis
Kenneth L. Brigham
Pleural Disease
209(2)
Mediastinal Disease
211(1)
Chest Wall Disease
211(2)
Neoplastic Diseases of the Lung
213(4)
Bonnie S. Slovis
Kenneth L. Brigham
Risk Factors
213(1)
Pathology
213(1)
Clinical Presentation
213(1)
Diagnosis and Evaluation
214(1)
Solitary Pulmonary Nodule
215(1)
Treatment and Prognosis
215(2)
Disordered Breathing
217(2)
Bonnie S. Slovis
Kenneth L. Brigham
Sleep Apnea Syndrome
217(1)
Other Breathing Disorders
217(2)
Environmental and Occupational Injury
219(4)
Bonnie S. Slovis
Kenneth L. Brigham
Pneumoconioses
219(1)
Air Pollution
219(1)
Noxious Gases and Fumes
219(1)
Smoke Inhalation
220(1)
High-Altitude Injury
221(1)
Drowning and Near-Drowning
221(2)
Essentials of Pulmonary Critical Care Medicine
223(4)
Bonnie S. Slovis
Kenneth L. Brigham
Shock
223(1)
Acute Respiratory Failure
224(1)
Oxygen Therapy
224(1)
Mechanical Ventilation
224(1)
Complications of Endotracheal Intubation and Mechanical Ventilation
225(1)
Systemic Inflammatory Response Syndrome, Sepsis, Multiple Organ Dysfunction Syndrome, and Adult Respiratory Distress Syndrome
226(1)
SECTION V Renal Disease
227(84)
Elements of Renal Structure and Function
229(8)
Jayant Kumar
Elements of Renal Structure
229(3)
Elements of Renal Physiology
232(5)
Approach to the Patient with Renal Disease
237(6)
Muhammad G. Alam
Sudhir V. Shah
Assessment of the Patient with Kidney Disease
237(3)
The Major Renal Syndromes
240(1)
Imaging of the Urinary Tract
241(1)
Renal Biopsy
242(1)
Fluid and Electrolyte Disorders
243(16)
Thomas E. Andreoli
Sameh R. Abul-Ezz
Volume Disorders
243(3)
Osmolality Disorders
246(1)
Hyponatremia
247(2)
Hypernatremia
249(1)
Disturbances in Potassium Balance
250(3)
Disturbances in Acid-Base Balance
253(6)
Glomerular Diseases
259(14)
Patrick D. Walker
Sudhir V. Shah
The Glomerulus
259(1)
Mechanisms of Glomerular Injury
259(1)
Clinical Manifestations of Glomerular Disease
259(1)
Approach to the Patient with Glomerular Disease
260(1)
Acute Nephritic Syndrome
260(2)
Rapidly Progressive Glomerulonephritis
262(1)
Nephrotic Syndrome
263(7)
Asymptomatic Urinary Abnormalities
270(3)
Major Nonglomerular Disorders
273(12)
Jayant Kumar
Patrick D. Walker
Tubulointerstitial Nephropathy
273(3)
Cystic Diseases of the Kidney
276(2)
Urinary Tract Obstruction
278(1)
Nephrolithiasis
279(2)
Renal Neoplasia
281(4)
Vascular Disorders of the Kidney
285(6)
Muhammad G. Alam
Renal Arterial Occlusion
285(1)
Ischemic Renal Disease
285(1)
Arterioles and Microvasculature
286(1)
Atheroembolic Diseases of the Kidney
286(1)
Chronic Hypertensive Nephrosclerosis
287(1)
Malignant Nephrosclerosis
287(1)
Scleroderma
287(1)
Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura
288(1)
Antiphospholipid-Antibody Syndrome and the Kidney
288(1)
Renal Vein Thrombosis
288(3)
Acute Renal Failure
291(10)
Didier Portilla
Mary Jo Shaver
Definition and Etiology
291(1)
Differential Diagnosis and Diagnostic Evaluation of the Patient
291(4)
Clinical Presentation, Complications, and Management of Acute Tubular Necrosis
295(1)
Specific Causes of Acute Renal Failure
296(5)
Chronic Renal Failure
301(10)
Mary Jo Shaver
Adaptation to Nephron Loss
301(1)
Conservative Management
301(2)
Clinical Manifestations
303(3)
Treatment of End-Stage Renal Failure
306(5)
SECTION VI Gastrointestinal Disease
311(78)
Common Clinical Manifestations of Gastrointestinal Disease
313(20)
Abdominal Pain
313(1)
Charles M. Bliss, Jr.
M. Michael Wolfe
Physiology
313(1)
Causes of Abdominal Pain
313(1)
Clinical Features
313(2)
The Acute Abdomen
315(1)
Chronic Abdominal Pain
315(2)
Gastrointestinal Hemorrhage
317(1)
Chi-Chuan Tseng
M. Michael Wolfe
Acute Gastrointestinal Hemorrhage
317(3)
Chronic Gastrointestinal Hemorrhage
320(1)
Malabsorption
320(1)
Elihu M. Schimmel
Digestion and Absorption of Fat
321(1)
Digestion and Absorption of Carbohydrates
321(1)
Digestion and Absorption of Proteins
321(1)
Mechanisms of Malabsorption
321(1)
Multiple Mechanisms
322(1)
Clinical Manifestations of Malabsorption
322(1)
Clinical Tests for Malabsorption
322(3)
Approach to the Patient with Suspected Malabsorption
325(2)
Diarrhea
327(1)
Satish K. Singh
Definition
327(1)
Normal Physiology
327(1)
Pathophysiology
328(2)
Evaluation of Diarrhea
330(3)
Endoscopic and Imaging Procedures
333(8)
Brian C. Jacobson
M. Michael Wolfe
Gastrointestinal Endoscopy
333(3)
Imaging Procedures
336(5)
Diseases of the Esophagus
341(6)
Robert C. Lowe
M. Michael Wolfe
Normal Function of the Esophagus
341(1)
Symptoms of Esophageal Disease
341(1)
Gastroesophageal Reflux Disease
342(1)
Dysphagia
343(1)
Esophageal Motility Disorders
344(2)
Other Esophageal Disorders
346(1)
Diseases of the Stomach and Duodenum
347(16)
Jaime A. Oviedo
M. Michael Wolfe
Gastroduodenal Anatomy
347(1)
Gastroduodenal Mucosal Secretion and Protective Factors
348(1)
Gastroduodenal Motor Physiology
349(1)
Gastritis
349(2)
Peptic Ulcer Disease
351(7)
Zollinger-Ellison Syndrome
358(2)
Gastroparesis
360(1)
Rapid Gastric Emptying
361(1)
Gastric Volvulus
361(1)
Bezoars
362(1)
Inflammatory Bowel Disease
363(10)
Lawrence J. Saubermann
Francis A. Farraye
Etiology
363(1)
Epidemiology
364(1)
Clinical Features
364(1)
Diagnosis
365(1)
Differential Diagnosis
366(1)
Extraintestinal Manifestations
367(1)
Differentiation between Ulcerative Colitis and Crohn's Disease
368(1)
Treatment (Induction of Remission and Maintenance of Remission)
368(5)
Neoplasms of the Gastrointestinal Tract
373(6)
Paul C. Schroy III
Esophageal Carcinoma
373(1)
Gastric Carcinoma
374(1)
Colorectal Polyps and Carcinoma
375(3)
Carcinoid Tumors
378(1)
Diseases of the Pancreas
379(10)
David R. Lichtenstein
Anatomy and Physiology
379(1)
Acute Pancreatitis
379(5)
Chronic Pancreatitis
384(2)
Carcinoma of the Pancreas
386(3)
SECTION VII Diseases of the Liver and Biliary System
389(40)
Laboratory Tests in Liver Disease
391(4)
Gary A. Abrams
Michael B. Fallon
Laboratory Tests of liver Function and Disease
391(2)
Liver Biopsy
393(2)
Jaundice
395(4)
Klaus E. Monkemuller
Michael B. Fallon
Bilirubin Metabolism
395(1)
Laboratory Tests for Bilirubin
395(1)
Classification of Jaundice
395(2)
Clinical Approach to Jaundice
397(2)
Acute and Chronic Hepatitis
399(10)
Aasim M. Sheikh
Michael B. Fallon
Acute Hepatitis
399(7)
Chronic Hepatitis
406(3)
Fulminant Hepatic Failure
409(2)
Brendan M. McGuire
Michael B. Fallon
Diagnosis
409(1)
Treatment
409(1)
Hepatic Transplantation
410(1)
Prognosis
410(1)
Cirrhosis of the Liver and Its Complications
411(8)
Miguel R. Arguedas
Michael B. Fallon
Clinical and Laboratory Features
411(1)
Specific Causes
411(1)
Major Complications
412(4)
Hepatic Transplantation
416(3)
Neoplastic, Infiltrative, and Vascular Diseases of the Liver
419(4)
Miguel R. Arguedas
Michael B. Fallon
Hepatic Neoplasms
419(1)
Liver Abscess
420(1)
Diagnostic Approach to Hepatic Lesions
420(1)
Infiltrative Disease of the Liver
421(1)
Vascular Disease of the Liver
422(1)
Disorders of the Gallbladder and Biliary Tract
423(6)
Klaus E. Monkemuller
Rudolf Garcia-Gallont
Michael B. Fallon
Normal Biliary Anatomy and Physiology
423(1)
Gallstones (Cholelithiasis
423(4)
Other Disorders of the Biliary Tree
427(2)
SECTION VIII Hematologic Disease
429(86)
Hematopoiesis and Hematopoietic Failure
431(7)
Eunice S. Wang
Nancy Berliner
Hematopoietic Tissues
431(1)
Stem Cell Theory of Hematopoiesis
431(1)
Hematopoietic Differentation Pathway
432(3)
Disorders of Hematopoiesis
435(3)
Clonal Disorders of the Hematopoietic Stem Cell
438(11)
Eunice S. Wang
Nancy Berliner
Myelodysplastic Disorders
438(2)
Myeloproliferative Disorders
440(4)
Acute Leukemias
444(5)
Disorders of Red Blood Cells
449(12)
Nancy Berliner
Normal Red Blood Cell Structure and Function
449(1)
Clinical Approach to Anemia
449(1)
Evaluation of Hypoproliferative Anemia
450(4)
Evaluation of Anemia with Reticulocytosis
454(7)
Clinical Disorders of Neutrophils
461(4)
Nancy Berliner
Normal Granulocyte Development, Structure, and Function
461(1)
Determinants of Peripheral Neutrophil Number
462(1)
Evaluation of Leukocytosis (Neutrophilia)
463(1)
Evaluation of Leukopenia (Neutropenia)
463(2)
Disorders of Lymphocytes
465(16)
Jill Lacy
Stuart Seropian
Cells of the Immune System: Lymphocyte Development, Function, and Localization
465(2)
Neoplasia of Lymphoid Origin
467(12)
Congenital and Acquired Disorders of Lymphocyte Function
479(1)
Infectious Disorders
480(1)
Normal Hemostasis
481(8)
Henry M. Rinder
Vascular Wall Physiology
481(1)
Platelet Physiology
482(3)
Coagulation Cascade
485(2)
Endothelial-Associated Fibrinolysis
487(2)
Disorders of Hemostasis: Bleeding
489(16)
Henry M. Rinder
Clinical Evaluation of Bleeding
489(1)
Vascular Causes of Bleeding
489(2)
Bleeding Caused by Platelet Disorders: Thrombocytopenia
491(6)
Bleeding Caused by Platelet Disorders: Qualitative Platelet Defects
497(3)
Fibrinogen Disorders
500(1)
Bleeding Caused by Coagulation Factor Disorders
500(3)
Bleeding in Patients with a Normal Laboratory Screen
503(2)
Disorders of Hemostasis: Thrombosis
505(10)
Henry M. Rinder
Clinical Evaluation of Thrombosis
505(1)
Vascular Causes of Thrombosis
505(1)
Atherothrombosis
505(2)
Inherited Risk Factors for Venous Thrombosis
507(1)
Acquired Risk Factors for Venous Thrombosis
508(1)
Hypercoagulability and Platelet Disorders
509(1)
Laboratory Evaluation of Thrombosis
510(1)
Therapy for Venous Thromboembolism
510(2)
Venous Thromboembolism during Pregnancy
512(1)
Perioperative Anticoagulation
513(2)
SECTION IX Oncologic Disease
515(32)
Cancer Etiology: Oncogenes and Environmental/Toxic Factors
517(4)
Christopher E. Desch
Cancer Phenotype
517(1)
Cancer Genetics
517(1)
Etiology
518(3)
Cancer Epidemiology and Cancer Prevention
521(4)
Jennifer J. Griggs
Cancer Epidemiology
521(1)
Cancer Prevention
521(4)
Solid Tumors
525(12)
Jennifer J. Griggs
Christopher B. Desch
Lung Cancer
525(2)
Head and Neck Cancers
527(1)
Gastrointestinal Cancers
527(4)
Endocrine Malignancies
531(1)
Breast Cancer
531(1)
Genitourinary Cancers
532(3)
Skin Cancer
535(1)
Cancer of Unknown Primary
536(1)
Metastases from Solid Tumors
536(1)
Complications of Cancer
537(4)
Jennifer J. Griggs
Spinal Cord Compression
537(1)
Superior Vena Cava Syndrome
538(1)
Hypercalcemia
538(1)
Paraneoplastic Syndromes
539(1)
Long-Term Effects of Cancer Treatment in Cancer Survivors
539(2)
Principles of Cancer Treatment
541(6)
Christopher E. Desch
Radiology
541(1)
Surgery
541(1)
Radiation Therapy
541(1)
Chemotherapy
542(1)
Hormonal Therapy
543(1)
Supportive Care
544(1)
Biologic Therapy
544(1)
Targeted Therapy
544(1)
Bone Marrow Transplantation
545(2)
SECTION X Metabolic Disease
547(34)
Eating Disorders
549(8)
Reed E. Pyeritz
Obesity
549(4)
Anorexia Nervosa and Bulimia Nervosa
553(4)
Principles of Nutritional Support in Adult Patients
557(6)
Reed E. Pyeritz
Nutritional Assessment
557(1)
Nutritional Requirements
557(1)
Malnutrition
557(1)
Nutritional Support
558(5)
Disorders of Lipid Metabolism
563(8)
Reed E. Pyeritz
Plasma Lipoprotein Physiology
563(1)
Evaluation of Serum Lipoprotein Concentrations
564(1)
Lipids and Vascular Disease
565(1)
General Principles of Management of Lipid Disorders
566(2)
Elevated Low-Density Lipoprotein
568(1)
Elevated Chylomicrons, Very-Low-Density Lipoprotein, and Intermediate-Density Lipoprotein
569(2)
Disorders of Metals and Metalloproteins
571(6)
David G. Brooks
Wilson's Disease
571(1)
Hemochromatosis
572(1)
Porphyrias
573(4)
Inherited Disorders of Connective Tissue
577(4)
Reed E. Pyeritz
Osteogenesis Imperfecta Syndromes
577(1)
Ehlers-Danlos Syndromes
577(1)
Marfan Syndrome
578(1)
Pseudoxanthoma Elasticum
579(2)
SECTION XI Endocrine Disease
581(66)
Hypothalamic-Pituitary Axis
583(10)
Vivien Bonert
Anatomy
583(1)
Anterior Pituitary Hormone Physiology and Testing
583(3)
Neuroradiologic Evaluation of the Pituitary Gland
586(1)
Pituitary and Hypothalamic Disorders
586(2)
Pituitary Tumors
588(2)
The Posterior Pituitary Gland
590(3)
The Thyroid Gland
593(10)
Vivien Bonert
Theodore C. Friedman
Thyroid Hormone Physiology
593(1)
Thyroid Evaluation
593(2)
Hyperthyroidism
595(2)
Thyroiditis
597(1)
Thyrotoxicosis Factitia
598(1)
Rare Causes of Thyrotoxicosis
598(1)
Hypothyroidism
598(2)
Subclinical Hypothyroidism
600(1)
Goiter
600(1)
Solitary Thyroid Nodules
600(1)
Thyroid Carcinoma
601(2)
The Adrenal Gland
603(12)
Theodore C. Friedman
Physiology
603(1)
Adrenal Insufficiency
603(4)
Hyporeninemic Hypoaldosteronism
607(1)
Congenital Adrenal Hyperplasia
607(1)
Syndromes of Adrenocorticoid Hyperfunction
608(5)
Adrenal Medullary Hyperfunction
613(2)
Male Reproductive Endocrinology
615(6)
Glenn D. Braunstein
Hypogonadism
615(3)
Gynecomastia
618(3)
Diabetes Mellitus
621(18)
Philip S. Barnett
Glenn D. Braunstein
Definition
621(1)
Diagnosis
621(2)
Classification
623(1)
Pathogenesis
624(2)
Management
626(7)
Complications
633(6)
Hypoglycemia
639(8)
Philip S. Barnett
Definition
639(1)
Physiology of Glucose Homeostasis
639(1)
Clinical Classification of Hypoglycemia
640(3)
Diagnostic Work-up of Hypoglycemia
643(1)
Treatment
644(3)
SECTION XII Women's Health
647(18)
Women's Health Topics
649(16)
Anne L. Taylor
June LaValleur
General Concepts
649(1)
Sex Differences in the Epidemiology of Disease by Age Group
649(1)
Exercise across the Feminine Life Cycle
650(1)
Sex/Gender and the Patient-Physician Interaction
650(1)
Hormonal Influences on Women's Health
651(1)
Normal Physiology
651(1)
Dysmenorrhea and Premenstrual Syndrome
651(2)
Amenorrhea
653(1)
Abnormal Uterine Bleeding
654(1)
Hormone Therapy
655(2)
Diseases Common in Women
657(1)
Cardiovascular Diseases
657(1)
Osteoporosis
658(2)
Breast Cancer and Benign Breast Disease
660(1)
Cancer of the Cervix, Uterus, and Ovary
660(1)
Sexually Transmitted Diseases and Pelvic Inflammatory Disease
661(1)
Urinary Incontinence
662(1)
Domestic Violence
663(1)
Disorders of Cognition and Affect
663(2)
SECTION XIII Men's Health
665(16)
Men's Health Topics
667(14)
Joseph A. Smith, Jr.
Douglas F. Milam
Ernest R. Smith, Jr.
Benign Prostatic Hyperplasia
667(1)
Pathophysiology
667(1)
Diagnosis
668(1)
Differential Diagnosis
669(1)
Management
669(3)
Prostatitis
671(1)
Acute Bacterial Prostatitis
672(1)
Chronic Bacterial Prostatitis
672(1)
Chronic Nonbacterial Prostatitis/CPPS
672(1)
Noninflammatory CPPS
673(1)
Erectile Dysfunction
673(1)
Mechanism of Erection
673(1)
Etiology of Erectile Dysfunction
674(1)
Medical and Surgical Treatment
675(2)
Future Treatments
677(1)
Carcinomas of Men
677(1)
Prostate Cancer
677(2)
Penile Carcinoma
679(1)
Testis Cancer
679(2)
SECTION XIV Diseases of Bone and Bone Mineral Metabolism
681(48)
Normal Physiology of Bone and Mineral Homeostasis
683(12)
Andrew F. Stewart
Calcium Homeostasis
683(6)
Phosphate Homeostasis
689(4)
Regulation of Serum Magnesium
693(2)
Disorders of Serum Minerals
695(14)
Andrew F. Stewart
Hypercalcemia
695(5)
Hypocalcemia
700(3)
Hyperphosphatemia
703(1)
Hypophosphatemia
704(2)
Hypermagnesemia
706(1)
Hypomagnesemia
706(3)
Metabolic Bone Diseases
709(6)
Andrew F. Stewart
Differential Diagnosis
709(5)
Treatment
714(1)
Osteoporosis
715(8)
Susan L. Greenspan
Epidemiology
715(1)
Risk Factors
715(1)
Peak Bone Mass and Bone Loss
715(1)
Clinical Manifestation
716(1)
Diagnosis
716(4)
Prevention
720(1)
Treatment
720(3)
Paget's Disease of Bone
723(6)
Mara J. Horwitz
G. David Roodman
Incidence and Prevalence
723(1)
Etiology
723(1)
Pathology and Pathophysiology
724(1)
Clinical Presentation
725(1)
Complications and Associated Conditions
726(1)
Diagnostic Evaluation
726(1)
Treatment
726(3)
SECTION XV Musculoskeletal and Connective Tissue Disease
729(66)
Approach to the Patient with Rheumatic Disease
731(4)
Joseph H. Korn
Musculoskeletal History and Examination
731(2)
Laboratory Testing
733(1)
Radiographic Studies
734(1)
Summary
734(1)
Rheumatoid Arthritis
735(6)
Joseph H. Korn
Epidemiology and Genetics
735(1)
Pathology
735(1)
Pathophysiology
735(1)
Clinical Features
735(2)
Diagnosis
737(1)
Treatment
737(2)
Prognosis
739(2)
Spondyloarthropathies
741(4)
Peter A. Merkel
Epidemiology
741(1)
Pathogenesis
741(1)
Clinical Features
741(2)
Radiographic Features
743(1)
Treatment
744(1)
Systemic Lupus Erythematosus
745(6)
Peter A. Merkel
Pathogenesis
745(1)
Clinical Manifestations
745(2)
Clinical Subsets
747(1)
Treatment
748(3)
Antiphospholipid Antibody Syndrome
751(2)
Peter A. Merkel
Etiology
751(1)
Clinical Features
751(1)
Diagnosis
751(1)
Treatment
751(2)
Systemic Sclerosis (Scleroderma)
753(6)
Joseph H. Korn
Epidemiology and Genetics
753(1)
Pathology and Pathophysiology
753(1)
Clinical Features
753(2)
Diagnosis and Differential Diagnosis
755(1)
Treatment
755(1)
Prognosis
756(3)
Idiopathic Inflammatory Myopathies
759(4)
Robert W. Simms
Pathology and Pathophysiology
759(1)
Clinical Presentation
759(2)
Diagnosis
761(1)
Differential Diagnosis
761(1)
Treatment
762(1)
Sjogren's Syndrome
763(4)
Peter A. Merkel
Clinical Features
763(1)
Diagnosis
763(2)
Treatment
765(2)
Vasculitides
767(6)
Peter A. Merkel
Classification
767(1)
Pathogenesis
767(1)
Clinical Features
767(1)
Specific Types of Vasculitis
768(2)
Diagnosis
770(1)
Autoantibodies and Vasculitis
771(1)
Treatment
771(2)
Crystal Arthropathies
773(6)
Joseph H. Korn
Gout
773(4)
Calcium Pyrophosphate Deposition Disease
777(1)
Other Crystal Disorders
777(2)
Osteoarthritis
779(4)
Robert W. Simms
Pathology
779(1)
Clinical Features and Diagnosis
780(1)
Treatment
780(3)
Nonarticular Soft Tissue Disorders
783(6)
Robert W. Simms
Etiology and Pathogenesis
783(1)
Classification of Bursae
783(1)
Diagnosis of Nonarticular Soft Tissue Disorders
783(1)
Bursitis
784(1)
Tendinitis
785(1)
Fibromyalgia Syndrome
785(4)
Rheumatic Manifestations of Systemic Disorders
789(6)
Robert W. Simms
Rheumatic Syndromes Associated with Malignancy
789(1)
Hematologic Disorders
789(2)
Gastrointestinal Diseases
791(1)
Endocrine Disorders
792(1)
Sarcoidosis
793(2)
SECTION XVI Infectious Disease
795(156)
Organisms That Infect Humans
797(6)
Michael M. Lederman
Viruses
797(1)
Prions
797(1)
Bacteria
797(3)
Fungi
800(2)
Protozoans
802(1)
Helminths
802(1)
Host Defenses Against Infection
803(8)
Michael M. Lederman
Robert A. Salata
Host Defenses versus Mechanisms of Microbial Pathogenesis: The Struggle for Survival
803(1)
Evolutionary Advantage of Adaptable Organisms
803(1)
Categories of Host Defenses and Risks for Infection
804(2)
How Cells Communicate with Other Cells
806(1)
How Enormous Diversity in Immune Recognition Is Possible
806(1)
Host-Microbe Interaction
807(2)
Microbial Pathogenesis versus Host Defenses-The Continuing Drama
809(2)
Laboratory Diagnosis of Infectious Diseases
811(4)
Michael M. Lederman
Diagnosis by Direct Visualization of the Organism
811(1)
Diagnosis by Detection of Microbial Antigens
811(1)
Diagnosis by Examination of Host Immune or Inflammatory Responses
812(1)
Assays That Detect Microbial Nucleotide Sequences
813(1)
Diagnosis by Isolation of the Organism in Culture
813(1)
Viral Isolation
814(1)
Isolation of Rickettsiae, Chlamydiae, and Mycoplasmas
814(1)
Bacterial Isolation
814(1)
Isolation of Fungi and Mycobacteria
814(1)
Antimicrobial Therapy
815(6)
Michael M. Lederman
The Pathogen
815(1)
Site of Infection
815(1)
Characteristics of the Antimicrobial
816(2)
Route of Administration
818(1)
Duration of Therapy
818(1)
Combinations
818(1)
Monitoring of Antimicrobial Therapy
818(1)
Antiviral Agents
819(1)
Antifungal Agents
819(1)
Antimicrobial Resistance Testing
819(2)
Fever and Febrile Syndromes
821(16)
Robert A. Salata
Regulation of Body Temperature
821(1)
Fever and Hyperthermia
821(1)
Acute Febrile Syndromes
822(10)
Fever of Undetermined Origin
832(3)
Factitious or Self-Induced Fever
835(2)
Bacteremia and Sepsis Syndrome
837(6)
Robert A. Salata
Epidemiology
837(1)
Pathogenesis
837(1)
Clinical Manifestations
838(3)
Diagnosis
841(1)
Therapy
841(2)
Infections of the Nervous System
843(12)
Scott A. Fulton
Robert A. Salata
Meningitis
844(6)
Encephalitis
850(1)
Rabies
851(1)
Spectrum of Tuberculous, Fungal, and Parasitic Infections
851(4)
Infections of the Head and Neck
855(6)
Michael M. Lederman
Infections of the Ear
855(1)
Infections of the Nose and Sinuses
855(1)
Infections of the Mouth and Pharynx
856(5)
Infections of the Lower Respiratory Tract
861(10)
Michael M. Lederman
Pathogenesis
861(1)
Epidemiology
861(1)
Differential Diagnosis
862(1)
Diagnosis
863(1)
Specific Pathogenic Organisms
864(4)
Treatment and Outcome
868(1)
Prevention
869(2)
Infections of the Heart and Vessels
871(8)
Michael M. Lederman
Infective Endocarditis
871(4)
Prosthetic Valve Endocarditis
875(1)
Prophylaxis of Infective Endocarditis
876(1)
Bacterial Endarteritis and Suppurative Phlebitis
877(2)
Skin and Soft Tissue Infections
879(6)
Michael M. Lederman
Superficial Infections of the Skin
879(4)
Deeper Infections of the Skin and Soft Tissue
883(2)
Intra-Abdominal Abscess and Peritonitis
885(4)
Michael M. Lederman
Intra-abdominal Abscess
885(2)
Peritonitis
887(2)
Infectious Diarrhea
889(6)
Michael M. Lederman
Pathogenesis and Pathophysiology: General Concepts
889(1)
Types of Microbial Diarrheal Diseases
889(3)
General Epidemiologic Considerations
892(1)
Diagnosis
892(1)
Management: General Principles of Electrolyte Repletion Therapy
892(3)
Infections Involving Bones and Joints
895(4)
Michael M. Lederman
Arthritis
895(2)
Septic Bursitis
897(1)
Osteomyelitis
897(2)
Infections of the Urinary Tract
899(4)
Michael M. Lederman
Urethritis
899(1)
Cystitis and Pyelonephritis
899(2)
Prostatitis
901(2)
Nosocomial Infections
903(4)
Robert A. Salata
Infection Control
903(1)
Approach to the Hospitalized Patient with Possible Nosocomial Infection
903(1)
Nosocomial Pneumonia
903(2)
Intravascular Catheter-Related Infections
905(1)
Nosocomial Urinary Tract Infection
906(1)
Surgical Site Infections
906(1)
Sexually Transmitted Diseases
907(10)
Keith B. Armitage
Robert A. Salata
Genital Sores
907(4)
Urethritis, Cervicitis, and Pelvic Inflammatory Disease
911(4)
Proctocolitis in Homosexual Men
915(1)
Vaginitis
915(2)
HIV Infection and the Acquired Immunodeficiency Syndrome
917(20)
Charles C. J. Carpenter
Timothy P. Flanigan
Michael M. Lederman
Epidemiology
917(2)
Pathophysiology
919(3)
Diagnosis and Testing for HIV Infection
922(1)
Sequential Clinical Manifestations of HIV-1 Infection
922(2)
Management of HIV Infection
924(3)
Management of Specific Clinical Manifestations of Immunodeficiency
927(7)
Other Complications of HIV Infection
934(1)
Prevention of HIV Infection
934(3)
Infections in the Immunocompromised Host
937(6)
Robert A. Salata
Disorders of Cell-Mediated Immunity
937(1)
Disorders of Humoral Immunity
937(1)
Impaired Neutrophil Function
938(1)
Neutropenia
939(1)
Diagnostic Problems in the Compromised Host
939(1)
Prevention and Treatment of Infections in the Patient with Neutropenia
940(3)
Infectious Diseases of Travelers: Protozoal and Helminthic Infections
943(8)
Keith B. Armitage
Robert A. Salata
Preparation of Travelers
943(2)
The Returning Traveler
945(1)
Protozoal and Helminthic Infections
946(5)
SECTION XVII Bioterrorism
951(8)
Bioterrorism
953(6)
Robert W. Bradsher, Jr.
Definition and Categorization
953(1)
History
953(2)
Biologic Agents
955(3)
Chemical Agents and Radiation
958(1)
SECTION XVIII Neurologic Disease
959(140)
Neurologic Evaluation of the Patient
961(6)
Frederick J. Marshall
Taking a Neurologic History
961(1)
The Neurologic Examination
961(2)
Technologic Assessment
963(4)
Disorders of Consciousness
967(8)
Roger P. Simon
Pathophysiology
967(1)
Diagnostic Approach
967(4)
Prognosis in Coma
971(1)
Coma-like States
971(4)
Disorders of Sleep
975(4)
Roger P. Simon
Neurobiology of Sleep
975(1)
Insomnia
975(1)
Abnormal Arousal
975(1)
Sleep Apnea
975(1)
Parasomnias
976(1)
Narcolepsy
977(2)
Cortical Syndromes
979(4)
Timothy J. Counihan
Anatomy
979(1)
Regional Syndromes
979(4)
Dementia and Memory Disturbances
983(6)
Frederick J. Marshall
Major Dementia Syndromes
983(3)
Other Memory Disturbances
986(1)
Molecular Genetics and the Future of Diagnosis and Treatment of Dementia
987(2)
Disorders of Mood and Behavior
989(6)
Frederick J. Marshall
Psychotic Disorders
989(1)
Depression and Bipolar Disorder
989(3)
Anxiety Disorders
992(1)
Somatoform Disorders
992(1)
Factitious Disorder
993(1)
Dissociative Disorders
993(1)
Personality Disorders and Substance Abuse
993(2)
Disorders of Thermal Regulation
995(2)
Roger P. Simon
Hypothermia
995(1)
Hyperthermia
995(2)
Headache, Neck Pain, and Other Painful Disorders
997(10)
Timothy J. Counihan
Headache
997(6)
Neck and Back Pain
1003(4)
Disorders of Vision and Hearing
1007(8)
Timothy J. Counihan
Disorders of Vision and Eye Movements
1007(3)
Hearing and Its Impairments
1010(5)
Dizziness
1015(4)
Roger P. Simon
Approach to the Diagnosis
1015(2)
Treatment
1017(2)
Disorders of the Motor System
1019(12)
Frederick J. Marshall
Symptoms and Signs of Motor System Disease
1019(1)
Movement Disorders and Ataxia
1019(3)
Hypokinetic Movement Disorders
1022(3)
Hyperkinetic Movement Disorders
1025(2)
Cerebellar Ataxias
1027(1)
Future Directions
1028(3)
Developmental and Neurocutaneous Disorders
1031(4)
Robert C. Griggs
Spinal Malformations
1031(1)
Chiari Malformations
1031(1)
Tethered Spinal Cord
1031(1)
Syringohydromyelia
1031(1)
Malformations of Cortical Development
1031(1)
Developmental and Neurocutaneous Disorders
1032(3)
Cerebrovascular Disease
1035(12)
Timothy J. Counihan
Epidemiology
1035(1)
Anatomy
1035(1)
Physiology
1035(1)
Ischemic Stroke
1036(2)
Major Stroke Syndromes
1038(2)
Diagnosis
1040(1)
Differential Diagnosis
1040(1)
Primary Stroke Prevention
1040(1)
Management of Acute Stroke
1041(2)
Intracerebral Hemorrhage
1043(1)
Intracranial Aneurysms
1044(1)
Vascular Malformations
1045(2)
Trauma to Head and Spine
1047(4)
Roger P. Simon
Head Injury
1047(1)
Spinal Cord Injury
1048(1)
Whiplash
1049(2)
Epilepsy
1051(10)
Robert C. Griggs
Definition
1051(1)
Incidence and Etiology
1051(1)
Classification and Clinical Manifestations
1051(4)
Diagnosis
1055(1)
Differential Diagnosis
1056(1)
Treatment
1057(2)
Prognosis
1059(1)
Discontinuing Antiepileptic Drugs
1059(2)
Central Nervous System Tumors
1061(4)
Jennifer J. Griggs
Classification
1061(1)
Clinical Manifestations
1061(1)
Evaluation of the Patient
1062(1)
Treatment
1062(1)
Specific Tumors
1063(2)
Infectious Diseases of the Nervous System
1065(4)
Robert C. Griggs
Roger P. Simon
Brain Abscess
1065(1)
Subdural Empyema
1066(1)
Malignant External Otitis
1066(1)
Spinal Epidural Abscess
1066(1)
Septic Cavernous Sinus Thrombosis
1067(1)
Lateral Sinus Thrombosis
1067(1)
Septic Sagittal Sinus Thrombosis
1067(1)
Neurologic Complications of Infectious Endocarditis
1067(1)
Prion Diseases
1068(1)
Demyelinating and Inflammatory Disorders
1069(6)
Robert C. Griggs
Multiple Sclerosis
1069(3)
Neuromyelitis Optica (Devic's Disease)
1072(1)
Optic Neuritis
1072(1)
Acute Transverse Myelitis
1073(1)
Acute Disseminated Encephalomyelitis
1073(2)
Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve Disease
1075(10)
Robert C. Griggs
Diagnostic Tests
1075(1)
Diseases of the Motor Neuron (Anterior Horn Cell)
1076(2)
Plexopathy
1078(1)
Peripheral Nerve Disease
1078(1)
Common Mononeuropathies
1079(1)
Polyneuropathies
1080(5)
Muscle Diseases
1085(10)
Robert C. Griggs
Organization and Structure of Muscle
1085(1)
Assessment
1085(2)
Muscular Dystrophies
1087(1)
Congenital Myopathies
1088(1)
Metabolic Myopathies
1088(2)
Channelopathies (Nondystrophic Myotonias and Periodic Paralyses)
1090(2)
Inflammatory Myopathies
1092(1)
Myopathies Caused by Endocrine and Systemic Disorders
1093(1)
Toxic Myopathies
1093(1)
Myoglobinuria
1093(2)
Neuromuscular Junction Disease
1095(4)
Robert C. Griggs
Myasthenia Gravis
1095(1)
Lambert-Eaton Myasthenic Syndrome
1096(1)
Drug-Induced Myasthenic Syndromes
1097(1)
Organophosphale Intoxication
1097(2)
SECTION XIX The Aging Patient
1099(10)
The Aging Patient
1101(8)
Hal H. Atkinson
Paul E. McGann
William B. Applegate
Normal Aging
1101(1)
Geriatric Assessment
1102(2)
The Geriatric Syndromes
1104(3)
Health Care Financing for the Elderly
1107(2)
SECTION XX Substance Abuse
1109(14)
Alcohol and Substance Abuse
1111(12)
Ivor J. Benjamin
Richard A. Large
L. David Hillis
Alcohol Dependence and Abuse
1111(3)
Prescription Drug Abuse
1114(4)
Illicit Drug Abuse
1118(3)
Future Perspectives
1121(2)
Appendix Commonly Measured Laboratory Values 1123(6)
Index 1129

Rewards Program

Write a Review