Cell and Molecular Biology: Concepts and Experiments, 6th Edition

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  • Edition: 6th
  • Format: Hardcover
  • Copyright: 2009-11-01
  • Publisher: Wiley
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Karp continues to help biologists make important connections between key concepts and experimentation. The sixth edition explores core concepts in considerable depth and presents experimental detail when it helps to explain and reinforce the concepts. The majority of discussions have been modified to reflect the latest changes in the field. The book also builds on its strong illustration program by opening each chapter with "VIP" art that serves as a visual summary for the chapter. Over 60 new micrographs and computer-derived images have been added to enhance the material. Biologists benefit from these changes as they build their skills in making the connection.

Table of Contents

Introduction to the Study of Cell and Molecular Biology
The Discovery of Cells
Basic Properties of Cells
Two Fundamentally Different Classes of Cells
The Chemical Basis of Life
Covalent Bonds
Noncovalent Bonds
Acids, Bases, and Buffers
The Nature of Biological Molecules
Four Types of Biological Molecules
The Formation of Complex Macromolecular Structures
Bioenergetics, Enzymes, and Metabolism
Enzymes as Biological Catalysts
The Structure of Function of the Plasma Membrane
An Overview of Membrane Functions
A Brief History of Studies on Plasma Membrane Structure
The Chemical Composition of Membranes
The Structure and Functions of Membrane Proteins
Membrane Lipids and Membrane Fluidity
The Dynamic Nature of the Plasma Membrane
The Movement of Substances Across Cell Membranes
Membrane Potentials and Nerve Impulses
Aerobic Respiration and the Mitochondrion
Mitochondrial Structure and Function
Oxidative Metabolism in the Mitochondrion
The Role of Mitochondria in the Formation of ATP
Translocation of Protons and Establishment of a Proton-Motive Force
The Machinery for ATP Formation
Photosynthesis and the Chloroplast
Chloroplast Structure and Function
An Overview of Photosynthetic Metabolism
The Absorption of Light
Photosynthetic Units and Reaction Centers
Carbon Dioxide Fixation and the Synthesis of Carbohydrate
Interactions Between Cells and Their Environment
The Extracellular Space
Interactions of Cells With Extracellular Materials
Interactions of Cells With Other Cells
Tight Junctions: Sealing the Extracellular Space
GAP Junctions and Plasmodesmata: Mediating Intercellular Communication
Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking
An Overview of the Endomembrane System
A Few Approaches to the Study of Endomembranes
The Endoplasmic Reticulum
The Golgi Complex
Types of Vesicle Transport and Their Functions
Plant Cell Vacuoles
The Endocytic Pathway: Moving Membrane and Materials into the Cell Interior
Posttranslational Uptake of Proteins By Peroxisomes, Mitochondria, and Chloroplasts
The Cytoskeleton and Cell Motility
Overview of the Major Functions of the Cytoskeleton
The Study of the Cytoskeleton
Intermediate Filaments
Muscle Contractility
Nonmuscle Motility
The Nature of the Gene and the Genome
The Concept of a Gene as a Unit of Inheritance
Chromosomes: The Physical Carriers of the Genes
The Chemical Nature of the Gene
The Structure of the Genome
The Stability of the Genome
Sequencing Genomes: The Footprints of Biological Evolution
Gene Expression: From Transcription to Translation
The Relationship Between Genes and Proteins
An Overview of Transcription in Both Prokaryotic and Eukaryotic Cells
Synthesis and Processing of Ribosomal and Transfer RNAs
Synthesis and Processing of Messenger RNAs
Small Regulatory RNAs and RNA Silencing Pathways
Encoding Genetic Information
Decoding the Condons: The Role of Transfer RNAs
Translating Genetic Information
The Cell Nucleus and the Control of Gene Expression
The Nucleus of a Eukaryotic Cell
Control of Gene Expression in Bacteria
Control of Gene Expression in Eukaryotes
Transcriptional-Level Control
Processing-Level Control
Translational-Level Control
Postranslational Control Determining Protein Stability
DNA Replication and Repair
DNA Replication
DNA Repair
Between Replication and Repair
Cellular Reproduction
The Cell Cycle
M Phase: Mitosis and Cytokinesis
Cell Signaling and Signal Transduction: Communication Between Cells
The Basic Elements of Cell Signaling Systems
A Survey of Extracellular Messengers and Their Receptors
G Protein-Coupled Receptors and Their Second Messengers
Protein-Tyrosine Phosphorylation as a Mechanism for Signal Transduction
The Role of Calcium as an Intracellular Messenger
Convergence, Divergence, and Crosstalk Among Different Signaling Pathways
The Role of No As An Intercellular Messenger
Apoptosis (Programmed Cell Death)
Basic Properties of a Cancer Cell
The Causes of Cancer
The Genetics of Cancer
New Strategies for Combating Cancer
The Immune Response
An Overview of the Immune Response
The Clonal Selection Theory As It Applies To B Cells
T Lymphocytes: Activation and Mechanism of Action
Selected Topics on the Cellular and Molecular Basis of Immunity
Techniques in Cell and Molecular Biology
The Light Microscope
Transmission Electron Microscopy
Scanning Electron and Atomic Force Microscopy
The Use of Radioisotopes
Cell Culture
The Fractionation of a Cell's Contents by Differential Centrifugation
Isolation, Purification, and Fractionation of Proteins
Determining the Structure of Proteins and Multisubunit Complexes
Purification of Nucleic Acids,
Fractionation of Nucleic Acids
Nucleic Acid Hybridization
Chemical Synthesis of DNA
Recombinant DNA Technology
Enzymatic Amplification of DNA by PCR
DNA Sequencing
DNA Libraries
DNA Transfer Into Eukaryotic Cells and Mammalian Embryos
Determining Eukaryotic Gene Function by Gene Elimination or Silencing
The Use of Antibodies
Additional Readings
Table of Contents provided by Publisher. All Rights Reserved.

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