Chemical Warfare Agents: Chemistry, Pharmacology, Toxicology, and Therapeutics, Second Edition

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  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2007-12-17
  • Publisher: CRC Press

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The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater sense of urgency within the field of chemical defense since this event, research related to chemical warfare agents (CWAs) continues to expand at a remarkable pace.Chemical Warfare Agents: Pharmacology, Toxicology, and Therapeutics, Second Edition explores the latest methods and products for preventing, diagnosing, and treating the acute and chronic effects of toxic CWA exposure. This edition cites the key developments in chemical defense research since 2001, including new epidemiological or clinical studies of exposed or potentially exposed populations; new treatment concepts and products; improved organization of the national response apparatus in the U.S. addressing the potential for CWA terrorism; and improved diagnostic tests that enable rapid diagnosis and treatment.Leading researchers explain how these breakthroughs help researchers determine physiologically relevant detection thresholds and develop more effective countermeasures and national response procedures. Chemical Warfare Agents provides first responders and emergency medical teams with the most up-to-date information they need to prepare for and handle natural disasters, chemical spills, terrorism, and warfare situations-quickly and effectively.

Table of Contents

Prefacep. xi
Acknowledgmentsp. xvii
Editorsp. xix
Contributorsp. xxi
Brief History and Use of Chemical Warfare Agents in Warfare and Terrorismp. 1
Chemistry of Chemical Warfare Agentsp. 21
Chemical Warfare Agent Threat to Drinking Waterp. 51
Health Effects of Low-Level Exposure to Nerve Agentsp. 71
Toxicokinetics of Nerve Agentsp. 97
Application of Genomic, Proteomic, and Metabolomic Technologies to the Development of Countermeasures against Chemical Warfare Agentsp. 123
Novel Approaches to Medical Protection against Chemical Warfare Nerve Agentsp. 145
Nerve Agent Bioscavengers: Progress in Development of a New Mode of Protection against Organophosphorus Exposurep. 175
Butyrylcholinesterase and Its Synthetic C-Terminal Peptide Confer In Vitro Suppression of Amyloid Fibril Formationp. 203
Novel Medical Countermeasure for Organophosphorus Intoxication: Connection to Alzheimer's Disease and Dementiap. 219
Inhalation Toxicology of Nerve Agentsp. 233
Vesicants and Oxidative Stressp. 247
Health Effects of Exposure to Vesicant Agentsp. 293
Cyanides: Toxicology, Clinical Presentation, and Medical Managementp. 313
Chemicals Used for Riot Control and Personal Protectionp. 343
Mechanism of Action of Botulinum Neurotoxin and Overview of Medical Countermeasures for Intoxicationp. 389
Ricin and Related Toxins: Review and Perspectivep. 423
Screening Smokes: Applications, Toxicology, Clinical Considerations, and Medical Managementp. 469
Clinical Detection of Exposure to Chemical Warfare Agentsp. 501
Personal Protective Equipment: Practical and Theoretical Considerationsp. 549
Chemical Warfare Agent Decontamination from Skinp. 611
Chemical Warfare, Chemical Terrorism, and Traumatic Stress Responses: An Assessment of Psychological Impactp. 627
Emergency Response to a Chemical Warfare Agent Incident: Domestic Preparedness, First Response, and Public Health Considerationsp. 653
Emergency Medical Response to a Chemical Terrorist Attackp. 675
Indexp. 713
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