9780521105897

The Chemistry and Biology of Benz[a]anthracenes

by
  • ISBN13:

    9780521105897

  • ISBN10:

    0521105897

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2009-06-04
  • Publisher: Cambridge University Press
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Summary

First published in 1988, this volume surveys the chemical synthesis and biological activity of the benz[a]anthracenes. These compounds occur in smoke and mineral oils and a few have been shown to be potent carcinogens. This volume was the first to review, systematically and in depth, the organic synthesis of these compounds as well as their metablolism, interactions with nucleic acids and protein, mutagenicity and carcinogenicity. Such studies have important implications in determining mechanism and specificity of chemically induced carcinogenesis.

Table of Contents

Chemistry
Synthetic routes from benzenes and naphthalenes
Synthetic routes from anthracenes (A-ring formation)
Synthetic routes from anthracenes (D-ring formation)
Biology
Metabolism
DNA, RNA and protein interactions
Mutagenicity
Carciogenicity
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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