Chemistry and Biology of Non-canonical Nucleic Acids

by Sugimoto, Naoki

• ISBN13: 9783527345212
• ISBN10: 3527345213
• Edition: 1st
• Format: Hardcover
• Copyright: 2021-06-01
• Publisher: Wiley-VCH

Summary

Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource

Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more.

An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry.

Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including:

* A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures
* The role played by nucleic acid structures in neurodegenerative diseases and various cancers
* An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids
* An introduction to the history of canonical and non-canonical structures of nucleic acids
* An analysis of the physicochemical properties of non-canonical nucleic acids

Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Author Biography

Professor Naoki Sugimoto received his Ph.D. degree from Kyoto University, Japan in 1985. After postdoctoral and research associate works at University of Rochester, NY, USA, he joined Konan University, Japan as an assistant professor in 1988. He is promoted as an associate professor in 1991, and then he becomes a full professor since 1994. From 2003, he is a director of Frontier Institute for Biomolecular Engineering Research (FIBER) at Konan University. He has published more than 400 scientific papers and books. He has received specific awards inside and outside of Japan. He is also member of the Editorial Board of the Nucleic Acids Research (~2007) and Scientific Reports (~2015). Now he is President of the Japan Society of Nucleic Acids Chemistry.

Table of Contents

Dedication

Foreword

Series editor's preface

Preface

brief table of contents

Table of Contents (ToC)

list of plates/figures/maps

list of tables

Notes on Contributors (LoC)

Acknowledgments (personal)

Acknowledgments (list of sources)

List of abbreviations

Glossary

Nomenclature/Notation

Timeline/Chronology

Maps

History for Canonical and Noncanonical Structures of Nucleic Acids

Structures of Nucleic Acids Now

Stability of Noncanonical Nucleic Acids

Physicochemical Properties of Noncanonical Nucleic Acids

Telomere

Transcription

Translation

Replication

Helicase

Dynamic Regulation of Biosystems by Nucleic Acids with Noncanomical Structures

Cancer and Nucleic Acids Structures

Neurodegenerative Diseases and Nucleic Acids Structures

Therapeutic Applications

Material Science and Nanotechnology of Nucleic Acids

Future outlook for chemistry and biology of noncanonical nucleic acids

Appendix

Glossary

Nomenclature/Notation

Notes

References

Bibliography

Credits and Sources/Acknowledgements

Table of Cases

Index