The Chemokine System in Experimental and Clinical Hematology

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-10-16
  • Publisher: Springer Verlag

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The aim of the issue is to describe and explain the importance of the chemokine system in hematology. The chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation. The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases

Table of Contents

The Chemokine System in Experimental and Clinical Hematologyp. 3
Experimental Hematology
Chemokine Decoy Receptors: Structure-Function and Biological Propertiesp. 15
Role of Chemokines in the Biology of Natural Killer Cellsp. 37
Chemokines in Angiogenesisp. 59
Immunobiology of Allogeneic Stem Cell Transplantation
Genetic Polymorphisms in the Cytokine and Chemokine System: Their Possible Importance in Allogeneic Stem Cell Transplantationp. 83
The Chemokine System: A Possible Therapeutic Target in Acute Graft Versus Host Diseasep. 97
Homing in on Acute Graft vs. Host Disease: Tissue-Specific T Regulatory and Th17 Cellsp. 121
Clinical Hematology
The Chemokine Network in Acute Myelogenous Leukemia: Molecular Mechanisms Involved in Leukemogenesis and Therapeutic Implicationsp. 149
CXCR4 in Clinical Hematologyp. 173
Immunobiology of Heparin-Induced Thrombocytopeniap. 193
Indexp. 203
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